DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CNTN1 and Nrg

DIOPT Version :9

Sequence 1:NP_001834.2 Gene:CNTN1 / 1272 HGNCID:2171 Length:1018 Species:Homo sapiens
Sequence 2:NP_001245581.1 Gene:Nrg / 31792 FlyBaseID:FBgn0264975 Length:1309 Species:Drosophila melanogaster


Alignment Length:1062 Identity:282/1062 - (26%)
Similarity:451/1062 - (42%) Gaps:138/1062 - (12%)


- Green bases have known domain annotations that are detailed below.


Human    33 SEEDKG-FGPIFEEQPINTIYPEESL-----EGKVS-----LNCRARASPFPVYKWRMNNGDVDL 86
            |.|.|| ..|...:||.    |.|.|     :.|.|     :.|.|...|.|.|.|..|....|.
  Fly    20 SAESKGNRPPRITKQPA----PGELLFKVAQQNKESDNPFIIECEADGQPEPEYSWIKNGKKFDW 80

Human    87 TSDRYSMV----GGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVR 147
            .:....|:    .|.|||..| |.:|.|.|.|.|||.:|...|....:....|:.|..|....:.
  Fly    81 QAYDNRMLRQPGRGTLVITIP-KDEDRGHYQCFASNEFGTATSNSVYVRKAELNAFKDEAAKTLE 144

Human   148 VKEGKGMVLLCDPPYHFPDDLSYRWLLNEF--PVFITMDKRRFVSQTNGNLYIANV---EASDKG 207
            ..||:..:|.|..|..||.. :..|::.|.  ....:::..|......|||:.:||   :||...
  Fly   145 AVEGEPFMLKCAAPDGFPSP-TVNWMIQESIDGSIKSINNSRMTLDPEGNLWFSNVTREDASSDF 208

Human   208 NYSCFVSSPSITKSVF---SKF---IPLIPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFAL 266
            .|:|  |:.|:.:|.:   :|.   :..:.:.....|..|....|..:...||.|:.:.|.|...
  Fly   209 YYAC--SATSVFRSEYKIGNKVLLDVKQMGVSASQNKHPPVRQYVSRRQSLALRGKRMELFCIYG 271

Human   267 GNPVPDIRWRKVLEPMPSTAEISTS--GAVLKIFNIQLEDEGIYECEAENIRGKDKHQARI---- 325
            |.|:|...|.|..:.:..:..|:..  |..|.|.....:|.|.|.|:..|..|..:..:.|    
  Fly   272 GTPLPQTVWSKDGQRIQWSDRITQGHYGKSLVIRQTNFDDAGTYTCDVSNGVGNAQSFSIILNVN 336

Human   326 ---YVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYHK-----------GEL 376
               |....||......|.||      .:.|.|.|.|.|.|.|:.||....:           ..:
  Fly   337 SVPYFTKEPEIATAAEDEEV------VFECRAAGVPEPKISWIHNGKPIEQSTPNPRRTVTDNTI 395

Human   377 RLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAA 441
            |:.::...:.|.|.|.|.|:.|.:|.:..|.:.|..||....|  ..:....|..|.|:|:...:
  Fly   396 RIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQAEPPTISEAP--AAVSTVDGRNVTIKCRVNGS 458

Human   442 PKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTR 506
            |||...|.:.:.|| ...|..:..:|.|||.::|.:|.|.|||:|:|..|:..:.|:||:.:.||
  Fly   459 PKPLVKWLRASNWL-TGGRYNVQANGDLEIQDVTFSDAGKYTCYAQNKFGEIQADGSLVVKEHTR 522

Human   507 IILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIR 571
            |...|.|.::..|::||.:|..:.|..|::...|..:|..|||..     |..|:..::..|.|.
  Fly   523 ITQEPQNYEVAAGQSATFRCNEAHDDTLEIEIDWWKDGQSIDFEA-----QPRFVKTNDNSLTIA 582

Human   572 NAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDI--RATSVALTWSRGSDNHSPI 634
            ......:|.|||.|:|.:|.::|.|:|:|:..|..|   ::..|  :|....:.|.:..||.|||
  Fly   583 KTMELDSGEYTCVARTRLDEATARANLIVQDVPNAP---KLTGITCQADKAEIHWEQQGDNRSPI 644

Human   635 SKYTIQTKTILSD-DWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNR 698
            ..||||..|..:. .|..|....|    |.:::..|.:.||..|.|||:|.|.:|...||..|:.
  Fly   645 LHYTIQFNTSFTPASWDAAYEKVP----NTDSSFVVQMSPWANYTFRVIAFNKIGASPPSAHSDS 705

Human   699 IKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKP------------FDG 751
            ..|....|...|.:|.|.|.....|.|:|.|:....|...||.|.|::|.            || 
  Fly   706 CTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEIEHNAPNFHYYVSWKRDIPAAAWENNNIFD- 769

Human   752 EEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVIN-SAQDAPSEAPTEV 815
              |::..:...|...:|          .:.:||.|.|::|:...:...|:. |.:|.|.:|||..
  Fly   770 --WRQNNIVIADQPTFV----------KYLIKVVAINDRGESNVAAEEVVGYSGEDRPLDAPTNF 822

Human   816 GVKVLSSSEIS-VHWEHVLEKIV----ESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDT 875
            .::.::||... :.|..|.|:.|    :.|:|:.|..::.||....:.|....::|.:....||:
  Fly   823 TMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTENEGEEGLREIHVKGDTHNALVTQFKPDS 887

Human   876 QYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGY 940
            :.:..:.|.|....||||.:|:..|.:..||....:.:.....|.:::.|..  .|.....:|||
  Fly   888 KNYARILAYNGRFNGPPSAVIDFDTPEGVPSPVQGLDAYPLGSSAFMLHWKK--PLYPNGKLTGY 950

Human   941 KVLYRPDGQH---DGKLYSTHKHSIEVPIPR-----------DGEYVVEVRAHSDGGDG---VVS 988
            |:.|....:.   :.:.|..|     :..||           :.:|.:.:.|.:..|:|   .:.
  Fly   951 KIYYEEVKESYVGERREYDPH-----ITDPRVTRMKMAGLKPNSKYRISITATTKMGEGSEHYIE 1010

Human   989 QVKISGAPTLSPSLLGLLLPAF 1010
            :..:..|..::|:     .|:|
  Fly  1011 KTTLKDAVNVAPA-----TPSF 1027

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CNTN1NP_001834.2 Ig1_Contactin-1 40..132 CDD:143257 32/105 (30%)
I-set 41..130 CDD:254352 32/102 (31%)
Ig2_Contactin-2-like 134..230 CDD:143204 26/106 (25%)
IG_like 144..221 CDD:214653 21/81 (26%)
Ig3_Contactin-1 241..328 CDD:143259 24/95 (25%)
IG_like 249..327 CDD:214653 21/86 (24%)
I-set 331..408 CDD:254352 23/87 (26%)
Ig 332..408 CDD:299845 22/86 (26%)
IG_like 422..501 CDD:214653 26/78 (33%)
Ig5_Contactin-1 429..501 CDD:143260 26/71 (37%)
IG_like 511..600 CDD:214653 27/88 (31%)
Ig6_Contactin_like 520..601 CDD:143171 24/80 (30%)
FN3 610..697 CDD:238020 29/89 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 693..717 7/23 (30%)
FN3 709..801 CDD:238020 24/103 (23%)
fn3 811..893 CDD:278470 22/86 (26%)
FN3 905..989 CDD:238020 18/100 (18%)
NrgNP_001245581.1 Ig 55..128 CDD:299845 24/73 (33%)
IG_like 57..127 CDD:214653 24/70 (34%)
Ig 135..214 CDD:299845 21/81 (26%)
IG_like 141..216 CDD:214653 20/77 (26%)
ig 251..332 CDD:278476 21/80 (26%)
I-set 339..427 CDD:254352 24/93 (26%)
Ig 354..427 CDD:299845 20/78 (26%)
I-set 432..517 CDD:254352 29/87 (33%)
Ig 446..517 CDD:299845 26/71 (37%)
I-set 522..611 CDD:254352 29/93 (31%)
ig 525..609 CDD:278476 26/88 (30%)
FN3 613..707 CDD:238020 32/100 (32%)
FN3 716..807 CDD:238020 24/103 (23%)
fn3 817..905 CDD:278470 22/87 (25%)
FN3 917..1004 CDD:238020 17/93 (18%)
FN3 1041..1111 CDD:238020
Bravo_FIGEY 1155..>1221 CDD:290593
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 59 1.000 Domainoid score I10657
eggNOG 1 0.900 - - E1_KOG3513
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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