DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CNR2 and Dop1R1

DIOPT Version :9

Sequence 1:	NP_001832.1	Gene:	CNR2 / 1269	HGNCID:	2160	Length:	360	Species:	Homo sapiens
Sequence 2:	NP_001262563.1	Gene:	Dop1R1 / 41726	FlyBaseID:	FBgn0011582	Length:	560	Species:	Drosophila melanogaster

Alignment Length:	388	Identity:	98/388 - (25%)
Similarity:	164/388 - (42%)	Gaps:	77/388 - (19%)

- Green bases have known domain annotations that are detailed below.

Human     2 EECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRR 66
            |..|.......:..|.:..|:....|:      .|.:..::|..||...|:.|...|.:...|||
  Fly   103 ESSWTNASEMDTIVGEEPEPLSLVSIV------VVGIFLSVLIFLSVAGNILVCLAIYTERSLRR 161

Human    67 KPSYLFIGSLAGAD-FLASVVFACSFVN----FHVFHG--VDSKAVFLLKIGSVTMTFTASVGSL 124
            ..: ||:.|||.|| |:||:|...:.||    :.:|..  .|:...|      ..|..|||:.:|
  Fly   162 IGN-LFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAF------DVMCSTASILNL 219

Human   125 LLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPL-MGWTCCPRPCSEL------ 182
            ...::|||:.::.|..|...:||..|::|:..:|:|:|.||::|: :|   ..||...|
  Fly   220 CAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVSFVPISLG---IHRPDQPLIFEDNG 281

Human   183 --FPLIPNDYLLSWLLF---IAFLFSGIIY--TYGHVLWKAHQHVASL----------------S 224
              :|....|...::.:.   |:|.|..::.  .|..:...|.:||.|:                |
  Fly   282 KKYPTCALDLTPTYAVVSSCISFYFPCVVMIGIYCRLYCYAQKHVKSIKAVTRPGEVAEKQRYKS 346

Human   225 GHQDRQVPGMARMR-----------LDVRLAKTLGLVLAVLLICWFPVLA--LMAHSLATTLSDQ 276
            ..:.:..|...::|           .|.:.|.|:|:::.|.||||.|...  :.|....|.:..|
  Fly   347 IRRPKNQPKKFKVRNLHTHSSPYHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTCIGGQ 411

Human   277 VKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLA---HWKKCVRGLGSEAKEEAPRSS 336
               .|...:.|...||..||:||::.:.|.|.:....|.   .| .|.:.:|:    ..||:|
  Fly   412 ---TFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILTMRNPW-CCAQDVGN----IHPRNS 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNR2	NP_001832.1	7tmA_CB2	34..310	CDD:320463	86/325 (26%)
		TM helix 1	36..60	CDD:320463	7/23 (30%)
		TM helix 2	70..91	CDD:320463	11/21 (52%)
		TM helix 3	107..129	CDD:320463	5/21 (24%)
		TM helix 4	152..168	CDD:320463	6/15 (40%)
		TM helix 5	187..210	CDD:320463	4/27 (15%)
		TM helix 6	244..266	CDD:320463	9/23 (39%)
		TM helix 7	278..303	CDD:320463	8/24 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..360		3/10 (30%)
Dop1R1	NP_001262563.1	7tm_4	134..>266	CDD:304433	45/138 (33%)
Dop1R1	NP_001262563.1	7tm_1	145..431	CDD:278431	78/298 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910