DRSC/TRiP Functional Genomics Resources

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Protein Alignment CNR2 and ser-5

DIOPT Version :9

Sequence 1:NP_001832.1 Gene:CNR2 / 1269 HGNCID:2160 Length:360 Species:Homo sapiens
Sequence 2:NP_492273.2 Gene:ser-5 / 184572 WormBaseID:WBGene00008890 Length:454 Species:Caenorhabditis elegans


Alignment Length:365 Identity:79/365 - (21%)
Similarity:149/365 - (40%) Gaps:87/365 - (23%)


- Green bases have known domain annotations that are detailed below.


Human     9 IANGSKDGLDSNPMKDYM-------ILSGPQ--KTAVAVLC---TLLGLLSALENVAVLYLILSS 61
            |:.|::..:.|...|:.:       :.:|.|  ...:.:||   .::.||:...|:.||:.   .
 Worm    26 ISTGNESDVVSEMCKEQLRIILREKLRTGEQLPPAVLVLLCIPAVIIILLTIFGNLLVLFF---K 87

Human    62 HQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAV---FLLKIG-SVTMTF-TASV 121
            .::.|..:.|.:.:|...|||..|:.......:.::.    |.:   ||.::. :..:|| |.||
 Worm    88 ARVGRTNTTLLVWNLGLTDFLVGVIVLPMGAVYLIYR----KWIFGRFLCRLWVAADVTFCTCSV 148

Human   122 GSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLI 186
            .::.:.::||||.:..|..||:::|:.:.:..:.|:|:.|:.: .|..:.|. .|....:....:
 Worm   149 VTICVISVDRYLAVTRPLRYKSIVTKTKVISVMTIIWIFSSSI-LLTTVRWE-QPECYDDSLCFV 211

Human   187 PND--YLLSWLLFIAFLFSGIIYTYGHVLWKAHQ------------------------------- 218
            .|:  :|...::|..||.:.:..|   :.|:.::                               
 Worm   212 GNEIRHLAHSVVFAFFLPASVTLT---LYWRIYKLARNRQKALDRGFLMILGSNMNFLTNTLSQQ 273

Human   219 -----HVASLSG---HQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLAL-----MAHSLA 270
                 |....:|   ||.|.      :|...|:|||||:|....|.||.|...|     ......
 Worm   274 TTLRVHFGKTNGMVEHQRRV------LRTHERIAKTLGVVSCSFLFCWLPFFGLYLTNYKCSGCV 332

Human   271 TTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSA 310
            ..::..|.....:|      |||:||:||:....|.:.||
 Worm   333 PPIAIDVASWLGYC------NSMLNPIIYSFTVKEFKRSA 366

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CNR2NP_001832.1 7tmA_CB2 34..310 CDD:320463 71/329 (22%)
TM helix 1 36..60 CDD:320463 7/26 (27%)
TM helix 2 70..91 CDD:320463 6/20 (30%)
TM helix 3 107..129 CDD:320463 6/23 (26%)
TM helix 4 152..168 CDD:320463 3/15 (20%)
TM helix 5 187..210 CDD:320463 6/24 (25%)
TM helix 6 244..266 CDD:320463 11/26 (42%)
TM helix 7 278..303 CDD:320463 8/24 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 327..360
ser-5NP_492273.2 7tmA_amine_R-like 64..365 CDD:320098 71/324 (22%)
TM helix 1 65..87 CDD:320098 7/24 (29%)
TM helix 2 96..118 CDD:320098 6/21 (29%)
TM helix 3 134..156 CDD:320098 5/21 (24%)
TM helix 4 179..195 CDD:320098 4/16 (25%)
TM helix 5 215..238 CDD:320098 5/25 (20%)
TM helix 6 298..323 CDD:320098 12/24 (50%)
TM helix 7 334..359 CDD:320098 9/30 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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