DRSC/TRiP Functional Genomics Resources

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Protein Alignment CNR2 and octr-1

DIOPT Version :9

Sequence 1:NP_001832.1 Gene:CNR2 / 1269 HGNCID:2160 Length:360 Species:Homo sapiens
Sequence 2:NP_001024569.1 Gene:octr-1 / 184469 WormBaseID:WBGene00006411 Length:408 Species:Caenorhabditis elegans


Alignment Length:393 Identity:71/393 - (18%)
Similarity:125/393 - (31%) Gaps:147/393 - (37%)


- Green bases have known domain annotations that are detailed below.


Human    35 AVAVLCTLLG--LLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVF 97
            ||..:.::|.  ||....|:.|:..:....:||.:.....|.|||.||.|..::.....:.:.: 
 Worm    21 AVLTISSMLTVMLLIIFGNLLVVVTVYRDRKLRMQRQNWLIVSLAVADMLVGLLVMPLTLTYEI- 84

Human    98 HGVDSKAVFLLKIGSVTM--------------TFTASVGSLLLTAIDRYLCLRYPPSYKALLTRG 148
                        :|..||              ..|||:..:...::|||..:..|.:|.|..|..
 Worm    85 ------------VGEWTMGNILCEIWLALDVLFVTASILHICAISLDRYFSVTSPLTYPATRTPL 137

Human   149 RALVTLGIMWVLSALVSYLPLMGWTCCPRP------CS-------ELFPLIPNDYLLSWLLFIAF 200
            |..:.:|:.|::|.|:...|:.||    ||      ||       .|:..:.:.|:...:|.|.:
 Worm   138 RMFIYIGVSWIVSLLICLPPIFGW----RPERAEGECSVSTDLGYVLYSSLGSFYIPVVILIIVY 198

Human   201 --LFSGIIYTYGH---------------------------------------------------- 211
              ::|   .|..|                                                    
 Worm   199 AKIYS---ITIRHSRQRLKETERRDHTLNMLTIRSSTNERYNMEYELEENSDPIEDEKEKVVTNR 260

Human   212 -----VLWKAHQ------------HVASLSGHQDRQVPGMARMRLDVRLAK-------------- 245
                 |.|:..:            .:|..:.|.......:.|...:.:..:              
 Worm   261 DMINKVCWQLRKISEELPRQGVKVSIALDTNHNSPPASDLTRKLEEKKFCEKRKRKLKAKERQAT 325

Human   246 -TLGLVLAVLLICWFP-----VLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSG 304
             .||::|:..::.|.|     |:....|.....:       |.|...|...||.:|||||.:.:.
 Worm   326 LLLGIILSAFILSWLPFFLIYVIGAFGHEAPPLV-------FKFFFWLGYCNSGINPVIYTVFNR 383

Human   305 EIR 307
            |.:
 Worm   384 EFK 386

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CNR2NP_001832.1 7tmA_CB2 34..310 CDD:320463 71/393 (18%)
TM helix 1 36..60 CDD:320463 6/25 (24%)
TM helix 2 70..91 CDD:320463 7/20 (35%)
TM helix 3 107..129 CDD:320463 6/35 (17%)
TM helix 4 152..168 CDD:320463 4/15 (27%)
TM helix 5 187..210 CDD:320463 5/24 (21%)
TM helix 6 244..266 CDD:320463 6/41 (15%)
TM helix 7 278..303 CDD:320463 10/24 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 327..360
octr-1NP_001024569.1 7tmA_alpha2_AR 22..389 CDD:320187 70/392 (18%)
TM helix 1 24..48 CDD:320187 5/23 (22%)
TM helix 2 58..80 CDD:320187 7/21 (33%)
TM helix 3 96..118 CDD:320187 3/21 (14%)
TM helix 4 141..157 CDD:320187 4/15 (27%)
TM helix 5 176..199 CDD:320187 4/22 (18%)
TM helix 6 322..347 CDD:320187 5/24 (21%)
TM helix 7 357..382 CDD:320187 10/31 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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