DRSC/TRiP Functional Genomics Resources

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Protein Alignment CNR2 and dop-1

DIOPT Version :9

Sequence 1:NP_001832.1 Gene:CNR2 / 1269 HGNCID:2160 Length:360 Species:Homo sapiens
Sequence 2:NP_001370620.1 Gene:dop-1 / 180714 WormBaseID:WBGene00001052 Length:460 Species:Caenorhabditis elegans


Alignment Length:442 Identity:90/442 - (20%)
Similarity:140/442 - (31%) Gaps:173/442 - (39%)


- Green bases have known domain annotations that are detailed below.


Human    42 LLGLLSAL------ENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVV-------------- 86
            ||||.|.|      .|:.|...||....||::|..||:.|||.:|.|.||:              
 Worm     8 LLGLFSVLIILALFGNLLVCAAILWDRSLRKQPENLFLVSLAVSDLLVSVLVMLFAAVNDILGYW 72

Human    87 ----FACSF-VNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLT 146
                |.|.| ::|.:                  .|.|||:.:|...::|||..:..|..|.....
 Worm    73 PFGQFYCQFWISFDI------------------TTCTASILNLCAISLDRYWHISRPMVYIRYCN 119

Human   147 RGRALVTLGIMWVLSALVSYLPL-MGW---------TCCPRPCSELFPLIPNDYLLSWLL---FI 198
            |.|....:.::|::||.:...|| .|:         |..| .|....||   .|.:...:   |:
 Worm   120 RRRINYVIVLVWLISAGIGAAPLGFGFGSKVTINNLTGLP-VCEMRLPL---PYAIGSSMVSFFL 180

Human   199 AFLFSGIIYTYGHVLWKAHQHVAS---------------LSGHQDRQV---------------PG 233
            ..:...|:||..::.  |.:||.|               |:..:.|:|               |.
 Worm   181 PAMVMVILYTKLYLY--ARKHVRSIKTQLQQATSFLIMQLASEKIREVTAATLKGEALLPPDSPA 243

Human   234 MARMRL----------------------------------------------------------- 239
            ..|..:                                                           
 Worm   244 TERTTMTVSRHYSRRSTTTTTTATPRRGDKKTSSQNKVESIRTSIFSKLNFLCPTRFKNQRSPQD 308

Human   240 -------------DVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQV-KKAFAFCSMLCLI 290
                         |.:...|||:::...|:||.|...:  :.|...|.:.. .|.....:.|...
 Worm   309 PHTPAAHNRSNISDQKARLTLGVIMGTFLVCWLPFFTV--NILRAWLPEIFSSKTIMAVTWLGYA 371

Human   291 NSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEA 342
            ||..||:||::.:.:.|.      |..|..||..|...:|.....|::...|
 Worm   372 NSSANPLIYSIFNRDFRR------AF
KKIIVRVFGCCWEEPDLNKSISSRYA 417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CNR2NP_001832.1 7tmA_CB2 34..310 CDD:320463 82/408 (20%)
TM helix 1 36..60 CDD:320463 9/23 (39%)
TM helix 2 70..91 CDD:320463 11/38 (29%)
TM helix 3 107..129 CDD:320463 5/21 (24%)
TM helix 4 152..168 CDD:320463 3/15 (20%)
TM helix 5 187..210 CDD:320463 5/25 (20%)
TM helix 6 244..266 CDD:320463 7/21 (33%)
TM helix 7 278..303 CDD:320463 8/24 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 327..360 3/16 (19%)
dop-1NP_001370620.1 7tmA_Ap5-HTB1-like 7..391 CDD:320193 82/414 (20%)
TM helix 1 8..32 CDD:320193 9/23 (39%)
TM helix 2 42..64 CDD:320193 9/21 (43%)
TM helix 3 80..102 CDD:320193 7/39 (18%)
TM helix 4 125..141 CDD:320193 3/15 (20%)
TM helix 5 167..190 CDD:320193 4/25 (16%)
TM helix 6 326..348 CDD:320193 7/23 (30%)
TM helix 7 359..384 CDD:320193 8/24 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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