Protein Alignment Chuk and IKKepsilon

DIOPT Version :9

• Sequence 1: XP_030106592.1
• Gene: Chuk / 12675
• MGIID: 99484
• Length: 757
• Species: Mus musculus
• Sequence 2: NP_610048.2
• Gene: IKKepsilon / 35329
• FlyBaseID: FBgn0086657
• Length: 720
• Species: Drosophila melanogaster
• Alignment Length: 787
• Identity: 168/787 - (21%)
• Similarity: 308/787 - (39%)
• Gaps: 209/787 - (26%)

Mouse     7 LRPGAGGPWEMRERLGTGGFGNVSLYQHRELDLKIAIKSCRLELSSKNRERWCHEIQIMKKLDHA 71
            ||......|.....||.|..|:|....::.....:|:|:.......:..:....|.:.:||::|.
  Fly     4 LRGSVSYVWCTTSVLGKGATGSVFQGVNKITGESVAVKTFNPYSHMRPADVQMREFEALKKVNHE 68

Mouse    72 NVVKACDVPEELNFLINDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLH 136
            |:||...:.|:..   ....::.||.|:||.|..:|:.|||..||.|.:.|.:|..:.:|:::|.
  Fly    69 NIVKLLAIEEDQE---GRGKVIVMELCTGGSLFNILDDPENSYGLPEHEFLLVLEHLCAGMKHLR 130

Mouse   137 ENKIIHRDLKPENI---VLQDVGGKTIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELFE---- 194
            :||::||||||.||   :.:|  |:||:|:.|.|.|::::......|..||.:||.|:|:|
  Fly   131 DNKLVHRDLKPGNIMKFISED--GQTIYKLTDFGAARELEDNQPFASLYGTEEYLHPDLYERAVL 193

Mouse   195 ----NKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPF-------TWHEKIKKKDPKCIFACE-E 247
                .:.:||.||.||.|..::....|..||    :||       |.|:...||....|...: .
  Fly   194 RKSIQRSFTANVDLWSIGVTLYHVATGNLPF----RPFGGRKNRETMHQITTKKASGVISGTQLS 254

Mouse   248 MTGEVRFSSHLPQPNSLCSLIVEPMESWLQLMLNWDPQQRGGPIDLTLKQPRCFALMDHILNLKI 312
            ..|.:.:|:.|| |::..|..::.:.:.|...|..:.:::....|      |.|..:..||..::
  Fly   255 ENGPIEWSTTLP-PHAHLSQGLKTLVTPLLAGLLEENREKTWSFD------RFFHEVTLILRKRV 312

Mouse   313 VHIL--NMTSAKIISFLLPCDESLHSLQSRIERETGINTGSQELL---SETGISLDPRKPASQCV 372
            :|:.  |.||: :..||.| ||.:.:.:.||..:|.:....|.||   ......:.||..|.
  Fly   313 IHVFFTNRTSS-VEVFLEP-DEQIDNFRERIFLQTEVPLEKQILLFNNEHLEKKVTPRTIAK--- 372

Mouse   373 LDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPIIQLRKVWAEAVHYVSGL 437
                    ::.....|:...:|..               .|:.:|||
  Fly   373 --------AFPATTTDQPIFLYSN---------------DDNNVQLP------------------ 396

Mouse   438 KEDYSRLFQGQRAAMLSLLRY-----------NANLTKMKNTLISASQQLKAKLEFFRKS---IQ 488
                         ..|.|.::           :|:|.|   :..|...:.|.:::.|...   |:
  Fly   397 -------------QQLDLPKFPVFPPNVSVENDASLAK---SACSVGHECKRRVDIFTSMDILIK 445

Mouse   489 LDLERYSEQMTYGIS-SEKMLKAWKEMEEKAIHYSEV---------------------------- 524
            ..:|.:.|.:...|: ..|..:::..:....|.|::|
  Fly   446 KGVEHFIEMLVTTITLLLKKTESFDNLLSTVIDYADVVHSMARVTKGDQEIKTLLTALENVKSDF 510

Mouse   525 ----GVIG------YLEDQIMSLHTEIMELQKSPYGRRQGDLMESLEQRAIDLYKQ-LKHRPPDH 578
                .||.      .::|::....|..|..:|.|...|.....:.|.:|..|.::. |:.|....
  Fly   511 DGAADVISQMHKHFVIDDELNDQWTSSMHGKKCPCKTRASAQAKYLVERLRDSWQHLLRDRATRT 575

Mouse   579 L-YSD----STEMVKI-------------------------------IVHTVQSQDRVL-KELFG 606
            | |:|    :.|.:|:                               :..||..:.::| |::..
  Fly   576 LTYNDEQFHALEKIKVDHNGKRIKALLLDNVNPTVAQIAECLADWYKLAQTVYLKTQILEKDVRD 640

Mouse   607 HLSKLLGCKQKIIDLLPKVEV-----------ALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQ 660
            ...||.|.:.::..:..::::           .|:.|:|. |.:..|| ::|:|:..:::   |.
  Fly   641 CERKLNGIRDELYHVKSELKLDVDTKTINNNNQLAKIEER-NRLRVMQ-QQQQEVMAVMR---TN 700

Mouse   661 SSARSLV 667
            |...||:
  Fly   701 SDIISLL 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chuk	XP_030106592.1	STKc_IKK_alpha	21..309	CDD:270941	87/306 (28%)
		Ubl_IKKA_like	311..387	CDD:340566	18/80 (23%)
		IKBKB_SDD	386..659	CDD:375823	55/374 (15%)
IKKepsilon	NP_610048.2	Pkinase	16..297	CDD:278497	83/290 (29%)
		STKc_TBK1	18..332	CDD:270890	95/331 (29%)
		UBL_TBK1_like	299..389	CDD:240618	24/117 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4250
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770