DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chrd and sog

DIOPT Version :9

Sequence 1:	XP_011244116.1	Gene:	Chrd / 12667	MGIID:	1313268	Length:	990	Species:	Mus musculus
Sequence 2:	NP_001259576.1	Gene:	sog / 32498	FlyBaseID:	FBgn0003463	Length:	1038	Species:	Drosophila melanogaster

Alignment Length:	1014	Identity:	285/1014 - (28%)
Similarity:	416/1014 - (41%)	Gaps:	192/1014 - (18%)

- Green bases have known domain annotations that are detailed below.

Mouse    60 TGQRPPAKPVPAGCSFGGKVYALDETWHPDLGEPFGVMRCVLCACEA-PQWARRGRGPGRVSCKN 123
            ||:| ..:|....|.||..:..|..||:.|||.|||||.|:.|.|.| |   ::.|...||.|:|
  Fly    90 TGRR-SNRPAVTECQFGKVLRELGSTWYADLGPPFGVMYCIKCECVAIP---KKRRIVARVQCRN 150

Mouse   124 IKPQCPTLACRQPRQLPGHCCQTCPQERSNLDPQPAGLVFEYPRDPEHRSYSDRGEPGVGERTRA 188
            ||.:||...|..|..|||.||:|||.:|::.|   ..|....|.:.|.|:..
  Fly   151 IKNECPPAKCDDPISLPGKCCKTCPGDRNDTD---VALDVPVPNEEEERNMK------------- 199

Mouse   189 DGHTDFVALLTGPRS------------------QAVARARVSLLRSSLRFS-VSYQRLDRPSRVR 234
                .:.|||||..|                  ..||.||....:.:|.:| .:..|:.||..::
  Fly   200 ----HYAALLTGRTSYFLKGEEMKSMYTTYNPQNVVATARFLFHKKNLYYSFYTSSRIGRPRAIQ 260

Mouse   235 FTDPTGNILFEHPATPTQDGLRRELRLRIAECDLFKVIWLVCGVWRAVPRLSVRLLRAEQLRVAL 299
            |.|..|.||.||....|..|     .|.:.:....|    :|||||.|||...|:||.::|.|.|
  Fly   261 FVDDAGVILEEHQLETTLAG-----TLSVYQNATGK----ICGVWRRVPRDYKRILRDDRLHVVL 316

Mouse   300 VTSTHPSGE--VWGPLIWQGALAAETFSAILTL------EDPLQRGVGGIALL-TLSDTEDSLHF 355
            :.......|  :.|.:....||..|.||::|..      .||...|.||.|:: |.|....|:|.
  Fly   317 LWGNKQQAELALAGKVAKYTALQTELFSSLLEAPLPDGKTDPQLAGAGGTAIVSTSSGAASSMHL 381

Mouse   356 LLLFRGLLGG--LAQAPL--KLQILHQGQLLRE--LQANTSAQEPGFAEVLPSLTDQEMDWLELG 414
            .|:|.|:.|.  .|.|.|  |:::..:.:::.:  .:....:.|....|:...::.|.:..:..|
  Fly   382 TLVFNGVFGAEEYADAALSVKIELAERKEVIFDEIPRVRKPSAEINVLELSSPISIQNLRLMSRG 446

Mouse   415 ELQMVLEKAGGPELRISGYITTRQSCDVLQSVLCGADALIPVQTGAAGSASFILLGNGSLIYQVQ 479
            :|.:.:|....|.|||.|:|.||.||::.|::|....|  ...|.::|.|...|..:|||.|.::
  Fly   447 KLLLTVESKKYPHLRIQGHIVTRASCEIFQTLLAPHSA--ESSTKSSGLAWVYLNTDGSLAYNIE 509

Mouse   480 V--VGTGSEVVAMTLETKPQRKNQRTVLCHMAGLQP--GGHMAVGMCSGLGARGAHMLLQNELFL 540
            .  |.|........:|.:.:||      ..:..|.|  ..:.|:|....||.:....|...||.:
  Fly   510 TEHVNTRDRPNISLIEEQGKRK------AKLEDLTPSFNFNQAIGSVEKLGPKVLESLYAGELGV 568

Mouse   541 NVGTKDFPDGELRGHVTALCYSGHSARYDRLPVPLAGAL-VLPPV-----------RSQAAGHAW 593
            ||.|:         |.|:|      .|...:|.|:|.|. ...|:           ...|.|.||
  Fly   569 NVATE---------HETSL------IRGRLVPRPVADARDSAEPILLKRQEHTDAQNPHAVGMAW 618

Mouse   594 LSLDTHCHLHYEVLLAGLGGSEQGTVTAHLLGPP----GMPGPQRLLKGFYGSEAQGVVKDLEPV 654
            :|:|..|:|||||.|.|:...:   :..:|...|    |.|..::||:.|.||..:|....:...
  Fly   619 MSIDNECNLHYEVTLNGVPAQD---LQLYLEEKPIEAIGAPVTRKLLEEFNGSYLEGFFLSMPSA 680

Mouse   655 LLRHLAQGTASLLITTKSSPRGELRGQVHIASQCEAGGLRLASEGVQMPLAPNGEAATSPMLPAG 719
            .|..|......|.:.:|.|.:..|||::               :..::|         ....|..
  Fly   681 ELIKLEMSVCYLEVHSKHSKQLLLRGKL---------------KSTKVP---------GHCFPVY 721

Mouse   720 PGPEAPVPAKHGSPGRPRDPNTCFFEGQQRPHGARWAPNYDPLCSLCICQRRTVICDPVVCPPPS 784
            .....|||..|...........||..|:......:|....|. |.:|.|.|....|:.:.||...
  Fly   722 TDNNVPVPGDHNDNHLVNGETKCFHSGRFYNESEQWRSAQDS-CQMCACLRGQSSCEVIKCPALK 785

Mouse   785 CPHPVQALD---QCCPVCPEKQRSRDLPSLPN--------LEPGEGCYFDGDRSWRAAGTRWHPV 838
            |....|.|.   :|||.|..|:.:.|..:..:        |:...||.. |:: :..||..|||.
  Fly   786 CKSTEQLLQRDGECCPSCVPKKEAADYSAQSSPATNATDLLQQRRGCRL-GEQ-FHPAGASWHPF 848

Mouse   839 VPPFGLIKCAVCTCKGATGEVHCEKVQCPRLACAQPVRANPTD--CCKQCPVG--SGTNAKLGDP 899
            :||.|...|..|:|...|.|:.|.::.||.|.|::.:...|..  |||.||.|  |.:|.....|
  Fly   849 LPPNGFDTCTTCSCDPLTLEIRCPRLVCPPLQCSEKLAYRPDKKACCKICPEGKQSSSNGHKTTP 913

Mouse   900 ----------MQ-----------ADGPRGCRFAGQWFPENQSWHPSVPPFGEMSCITCRCGAGVP 943
                      ||           |:|  ||:...:.:...|.|||.:...||..||.|||.....
  Fly   914 NNPNVLQDQAMQRSPSHSAEEVLANG--GCKVVNKVYENGQEWHPILMSHGEQKCIKCRCKDSKV 976

Mouse   944 HCERDDCSPPLSCGSGKESRCCSHCTAQRSASETRTLPE 982
            :|:|..||.             |.|..|...:..|.|.|
  Fly   977 NCDRKRCSR-------------STCQQQTRVTSKRRLFE 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chrd	XP_011244116.1	VWC	73..147	CDD:327433	35/74 (47%)
		CHRD	192..314	CDD:214804	42/142 (30%)
		CHRD	322..435	CDD:214804	33/125 (26%)
		CHRD	441..558	CDD:214804	29/120 (24%)
		CHRD	571..683	CDD:214804	37/127 (29%)
		VWC	742..799	CDD:327433	18/59 (31%)
		VWC	820..886	CDD:214564	24/67 (36%)
		VWC	908..968	CDD:327433	17/59 (29%)
sog	NP_001259576.1	VWC	102..174	CDD:278520	35/74 (47%)
		CHRD	200..334	CDD:214804	42/142 (30%)
		CHRD	341..467	CDD:214804	33/125 (26%)
		CHRD	473..585	CDD:214804	32/134 (24%)
		CHRD	594..708	CDD:214804	33/116 (28%)
		VWC	744..803	CDD:278520	18/59 (31%)
		VWC	832..898	CDD:278520	24/67 (36%)
		VWC	941..1017	CDD:278520	22/75 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	92	1.000	Domainoid score	I7611
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2774
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2461
Isobase	1	0.950	-	0	Normalized mean entropy	S7450
OMA	1	1.010	-	-		QHG49605
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008063
OrthoInspector	1	1.000	-	-		oto92316
orthoMCL	1	0.900	-	-		OOG6_107806
Panther	1	1.100	-	-	LDO	PTHR46526
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4763
SonicParanoid	1	1.000	-	-		X6013
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.950