DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chek1 and grp

DIOPT Version :9

Sequence 1:	NP_031717.2	Gene:	Chek1 / 12649	MGIID:	1202065	Length:	476	Species:	Mus musculus
Sequence 2:	NP_477011.1	Gene:	grp / 34993	FlyBaseID:	FBgn0261278	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	236/509 - (46%)
Similarity:	317/509 - (62%)	Gaps:	60/509 - (11%)

- Green bases have known domain annotations that are detailed below.

Mouse     5 FVEDWDLVQTLGEGAYGEVQLAVNRITEEAVAVKIVDMKRAIDCPENIKKEICINKMLSHENVVK 69
            |||.|.|.|||||||||||:|.:||.|.||||:|:||:|:..|...:::||:||.|||..:::::
  Fly    18 FVEGWTLAQTLGEGAYGEVKLLINRQTGEAVAMKMVDLKKHPDAANSVRKEVCIQKMLQDKHILR 82

Mouse    70 FYGHRREGHIQYLFLEYCSGGELFDRIEPDIGMPEQDAQRFFHQLMAGVVYLHGIGITHRDIKPE 134
            |:|.|.:|.::|:||||.:|||||||||||:|||:.:|||:|.||::|:.|||..||.|||:|||
  Fly    83 FFGKRSQGSVEYIFLEYAAGGELFDRIEPDVGMPQHEAQRYFTQLLSGLNYLHQRGIAHRDLKPE 147

Mouse   135 NLLLDERDNLKISDFGLATVFRHNNRERLLNKMCGTLPYVAPELLKRKEFHAEPVDVWSCGIVLT 199
            ||||||.||:||||||:||:||...:||||:|.||||||||||:| :|.:||:|.|:||||::|.
  Fly   148 NLLLDEHDNVKISDFGMATMFRCKGKERLLDKRCGTLPYVAPEVL-QKAYHAQPADLWSCGVILV 211

Mouse   200 AMLAGELPWDQPSDSCQEYSDWKEKKTY--LNPWKKIDSAPLALLHKILVETPSARITIPDIKKD 262
            .||||||||||||.:|.|:::|::...:  ..||.|:|:..::||.|:|..:|..|:|:......
  Fly   212 TMLAGELPWDQPSTNCTEFTNWRDNDHWQLQTPWSKLDTLAISLLRKLLATSPGTRLTLEKTLDH 276

Mouse   263 RWYNKPL-------------------NRGAKRPRATSGGMSESSSGFSKHIHSNLDFSPVNNGSS 308
            :|.|...                   :..|||.|..|          |.|:.:.||.|...|
  Fly   277 KWCNMQFADNERSYDLVDSAAALEICSPKAKRQRLQS----------SAHLSNGLDDSISRN--- 328

Mouse   309 EETVKFSSSQPEPR------------TGLSLWDTGPSNVDKLVQ----GISFSQPTCPEHMLVNS 357
                  ..|||.|.            :|.|..|.|....  |.|    ..|||||...:.:|:.:
  Fly   329 ------YCSQPMPTMRSDDDFNVRLGSGRSKEDGGDRQT--LAQEARLSYSFSQPALLDDLLLAT 385

Mouse   358 QLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETFEKL-GYQWKKSCMNQVTVSTTDRRN 421
            |:..|..:|||.:||||:||||||.....|.:.:.|..|.|:| ||..|......|||||.||..
  Fly   386 QMNQTQNASQNYFQRLVRRMTRFFVTTRWDDTIKRLVGTIERLGGYTCKFGDDGVVTVSTVDRNK 450

Mouse   422 NKLIFKINLVEMDEKILVDFRLSKGDGLEFKRHFLKIKGKLSDVVSSQKVWFPV 475
            .:|:||.:::|||.|||||.|||||.||||||.|:|||..|.|:|......:|:
  Fly   451 LRLVFKAHIIEMDGKILVDCRLSKGCGLEFKRRFIKIKNALEDIVLKGPTTWPI 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chek1	NP_031717.2	Interaction with CLSPN. /evidence=ECO:0000250	1..265		147/261 (56%)
		STKc_Chk1	7..265	CDD:270971	145/259 (56%)
		S_TKc	9..264	CDD:214567	144/256 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..331		18/94 (19%)
		Autoinhibitory region. /evidence=ECO:0000250	391..476		44/86 (51%)
grp	NP_477011.1	STKc_Chk1	20..279	CDD:270971	145/259 (56%)
grp	NP_477011.1	S_TKc	22..278	CDD:214567	144/256 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850608
Domainoid	1	1.000	324	1.000	Domainoid score	I1197
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H975
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1697
Isobase	1	0.950	-	0	Normalized mean entropy	S1926
OMA	1	1.010	-	-		QHG48669
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001125
OrthoInspector	1	1.000	-	-		oto92830
orthoMCL	1	0.900	-	-		OOG6_104812
Panther	1	1.100	-	-	LDO	PTHR24343
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R198
SonicParanoid	1	1.000	-	-		X2646
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.840