DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Chad and Toll-7

DIOPT Version :9

Sequence 1:NP_031715.1 Gene:Chad / 12643 MGIID:1096866 Length:358 Species:Mus musculus
Sequence 2:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster


Alignment Length:355 Identity:95/355 - (26%)
Similarity:137/355 - (38%) Gaps:98/355 - (27%)


- Green bases have known domain annotations that are detailed below.


Mouse    16 LPALAACPQNCHCHGDLQHVICDKVGLQKIPKVSETTKLLNLQRNNFPVLAANSFRTMPNLVSLH 80
            ||:...||.     |:||                    :|||.||.........|..|       
  Fly   204 LPSGFLCPV-----GNLQ--------------------VLNLTRNRIRTAEQMGFADM------- 236

Mouse    81 LQHCNIREVAAGAFRGLKQLIYLYLSHNDIR-VLRAGAFDDLTELTYLYLDHNKVSELPRGLLSP 144
              :|.....:||:     :|..|..|||::| :..:.....|..|.:|.|.:|.:|||....|:.
  Fly   237 --NCGAGSGSAGS-----ELQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAG 294

Mouse   145 LVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGSLDDVENLAKFHLDKNQLSS- 208
            |.:|.|:.|:||.:..|..|.|.|:|:||.::|.:|.|..|..|....:|.|....|..|||:| 
  Fly   295 LASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSN 359

Mouse   209 -----------------YPSAALSKL--RVVEE------LKLSHNPLKSIPDNAFQSF------- 241
                             ....||:::  |..:|      |.|.:|.:..|.||||...       
  Fly   360 HVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLN 424

Mouse   242 ---------------GRY-LETLWLDNTNLEKFSDAAFSGVTTLKHVHLDNNRLNQLPSSF-PFD 289
                           |.| |..|.|:|..:.....|.|...:.||.:.|.:|:||::|.:. ...
  Fly   425 LAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLA 489

Mouse   290 NLETL--------TLTNNPWKCTCQLRGLR 311
            .|.||        |..|..:|...||.|||
  Fly   490 MLRTLDLGENQIRTFDNQSFKNLHQLTGLR 519

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ChadNP_031715.1 LRRNT 22..48 CDD:279764 5/25 (20%)
LRR 1 51..72 6/20 (30%)
leucine-rich repeat 52..75 CDD:275380 7/22 (32%)
LRR_8 74..134 CDD:290566 14/60 (23%)
LRR 2 75..96 3/20 (15%)
leucine-rich repeat 76..99 CDD:275380 3/22 (14%)
LRR_RI <89..281 CDD:238064 67/241 (28%)
LRR 3 99..120 6/21 (29%)
leucine-rich repeat 100..123 CDD:275380 7/23 (30%)
LRR 4 123..144 8/20 (40%)
leucine-rich repeat 124..147 CDD:275380 9/22 (41%)
LRR_8 147..206 CDD:290566 21/58 (36%)
LRR 5 147..168 8/20 (40%)
leucine-rich repeat 148..171 CDD:275380 9/22 (41%)
LRR 6 171..192 7/20 (35%)
leucine-rich repeat 172..195 CDD:275380 7/22 (32%)
LRR 7 195..216 8/38 (21%)
leucine-rich repeat 196..219 CDD:275380 8/42 (19%)
LRR 8 219..240 9/26 (35%)
LRR_8 220..279 CDD:290566 21/87 (24%)
leucine-rich repeat 220..243 CDD:275380 9/50 (18%)
LRR 9 244..265 7/21 (33%)
leucine-rich repeat 245..268 CDD:275380 6/22 (27%)
LRR 10 268..289 7/21 (33%)
leucine-rich repeat 269..291 CDD:275380 7/22 (32%)
LRRCT 299..346 CDD:214507 6/13 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 322..358
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566
leucine-rich repeat 136..159 CDD:275380
leucine-rich repeat 160..190 CDD:275380
LRR_8 189..259 CDD:290566 22/93 (24%)
leucine-rich repeat 191..214 CDD:275380 4/14 (29%)
leucine-rich repeat 215..248 CDD:275380 12/66 (18%)
LRR_RI 247..501 CDD:238064 70/258 (27%)
LRR_8 247..308 CDD:290566 21/65 (32%)
leucine-rich repeat 249..273 CDD:275380 7/23 (30%)
leucine-rich repeat 274..297 CDD:275380 9/22 (41%)
LRR_8 297..356 CDD:290566 21/58 (36%)
leucine-rich repeat 298..321 CDD:275380 9/22 (41%)
leucine-rich repeat 322..345 CDD:275380 7/22 (32%)
LRR_8 345..406 CDD:290566 13/60 (22%)
leucine-rich repeat 346..371 CDD:275380 6/24 (25%)
leucine-rich repeat 372..395 CDD:275380 4/22 (18%)
leucine-rich repeat 396..419 CDD:275380 8/22 (36%)
LRR_8 419..478 CDD:290566 12/58 (21%)
leucine-rich repeat 420..443 CDD:275380 1/22 (5%)
leucine-rich repeat 444..467 CDD:275380 6/22 (27%)
LRR_RI 466..622 CDD:238064 18/54 (33%)
leucine-rich repeat 468..488 CDD:275380 7/19 (37%)
LRR_8 491..549 CDD:290566 11/29 (38%)
leucine-rich repeat 491..514 CDD:275380 6/22 (27%)
leucine-rich repeat 515..536 CDD:275380 4/5 (80%)
leucine-rich repeat 539..562 CDD:275380
leucine-rich repeat 563..585 CDD:275380
leucine-rich repeat 586..626 CDD:275380
leucine-rich repeat 627..653 CDD:275380
LRRCT 716..772 CDD:214507
LRRNT 796..830 CDD:214470
leucine-rich repeat 812..829 CDD:275380
leucine-rich repeat 833..854 CDD:275380
LRR_8 853..913 CDD:290566
leucine-rich repeat 855..878 CDD:275380
LRR_4 878..918 CDD:289563
leucine-rich repeat 879..902 CDD:275380
leucine-rich repeat 903..926 CDD:275380
leucine-rich repeat 927..953 CDD:275380
TIR 1098..1235 CDD:214587
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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