DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cftr and MRP

DIOPT Version :9

Sequence 1:NP_066388.1 Gene:Cftr / 12638 MGIID:88388 Length:1476 Species:Mus musculus
Sequence 2:NP_723772.2 Gene:MRP / 34686 FlyBaseID:FBgn0032456 Length:1549 Species:Drosophila melanogaster


Alignment Length:1492 Identity:386/1492 - (25%)
Similarity:678/1492 - (45%) Gaps:240/1492 - (16%)


- Green bases have known domain annotations that are detailed below.


Mouse     5 PLEKASFISKLFFSWTTPILRKGYRHHLELSDIYQAPSADSADHLSEKLEREWDRE--------- 60
            |...|||:|::.:.|...:..||||:.||..|::.....||...:.......|::.         
  Fly   225 PELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKA 289

Mouse    61 -----------QASKKNP------------QLIHALRRCFFWRFLFYGILLYLGEVTKAVQPVLL 102
                       ..:.:||            .::..:.:.|...|||..::....:.....||.:|
  Fly   290 RVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVL 354

Mouse   103 GRIIASYDPENKVERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHRIGMQMRTAMFSLIYKKTLKL 167
            ..||:..:.::.......|...:.|.:|...:|.:|......:..:|:::|||:.:.||:|.|::
  Fly   355 SLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRI 419

Mouse   168 SSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFIWIAPLQVTLLMGLLWDLLQFSAFCGLGLLII 232
            |:....:.::|::|:|::.:..:|.|.....:.||.||||:.|.:..||..|..|...||.::||
  Fly   420 SNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMII 484

Mouse   233 LVIFQAILGKMMVKYRDQRAAKINERLVITSEIIDNIYSVKAYCWESAMEKMIENLREVELKMTR 297
            |:....::...:..|:.::....:||:.:.:|::..|..:|.|.||.:.||.:.::|:.|:...|
  Fly   485 LIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLR 549

Mouse   298 KAAYMRFFTSSAFFFSGFFVVFLSVLPYTV---INGIVLRKIFTTISFCIVLRMSVTRQFPTAVQ 359
            ..||:...||..:..:.|.|..::...|.:   .|.:.:.|:..:|:...::::.:|.....:|.
  Fly   550 STAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVD 614

Mouse   360 IWYDSFGMIRKIQDFLQKQEYKVLEYNLMTTGIIMENVTAFWEEGFGELLEKVQQSNGDRKHSSD 424
            | .::...:.:|..||..:|   |:.|.:.                         .:..:.|...
  Fly   615 I-AETQVSVNRINKFLNSEE---LDPNSVL-------------------------HDSSKPHPMS 650

Mouse   425 ENNVSFSHLCLVGNPV-LKNINLNIEKGEMLAITGSTGSGKTSLLMLILGELEASEGIIKHSGRV 488
            ..|..||.    |:.: |:|||:.::||.::|:.|:.||||:|::...|||:|...|::...|::
  Fly   651 IENGEFSW----GDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKL 711

Mouse   489 SFCSQFSWIMPGTIKENIIFGVSYDEYRYKSVVKACQLQQDITKFAEQDNTVLGEGGVTLSGGQR 553
            ::..|.:||...|:::||:||.:||..||..|:.||.|:.||...:..|.|.:||.|:.|||||:
  Fly   712 AYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQK 776

Mouse   554 ARISLARAVYKDADLYLLDSPFGYLDVFTEEQVFESCVCK--LMANKTRILVTSKMEHLRKADKI 616
            .|||||||||.||||||||.|...:|....:.:||..:..  ::|.|:|:|||..:..|.:.|.|
  Fly   777 QRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSI 841

Mouse   617 LILHQGSSYFYGTFSELQSLRPDFSSKLMGYDTFDQFTEERRSSILTETLRRFSVDDSSAPWSKP 681
            .::..|.....|||.:|...:..|:..::.:                                  
  Fly   842 YVIKMGEISESGTFDQLVKNKGAFADFIIQH---------------------------------- 872

Mouse   682 KQSFRQTGEVGEKRKNSILNSFSSVRKISIVQKTPLCIDGESDDLQEKRLSLVPDSEQGEAALPR 746
                .|.|...|:..|.|....||...:..:..|           .||.:.|.            
  Fly   873 ----LQEGNEEEEELNQIKRQISSTADVPELLGT-----------VEKAIKLA------------ 910

Mouse   747 SNMIATGPTFPGRRRQSVLDLMTFTP-----NSGSSNLQRTRTSIRKISLVPQISLNEVDVYSRR 806
                         |.:|:.|.::.|.     ..|.|..:||:......|:....||.:......:
  Fly   911 -------------RTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGK 962

Mouse   807 LSQDSTLNITEEINEEDLKECFLDDVIKIPPVTTWNTYLRYFTLHK------GLLLVLIWCVLVF 865
            |.:      ||:.....::                      |.::|      |:.|.:...||.|
  Fly   963 LIE------TEKSQTGGVE----------------------FAVYKHYIKSVGIFLSVATLVLNF 999

Mouse   866 LVEVAASLFVLWLLK-NNPVNSGNN-GTKISNSSYVVIITSTSF-------YYIFYIYVGVADTL 921
            :.:.......|||.: .|..|..|: |.:   ..|:.:..:..|       :.:..:|:|.    
  Fly  1000 VFQAFQIGSNLWLTQWANDQNVANDTGLR---DMYLGVYGAFGFGQGVLAYFAVVIVYLGG---- 1057

Mouse   922 LALSLFRGLPLVHTLITASKILHRKMLHSILHAPMSTISKL-KAGGILNRFSKDIAILDDFLPLT 985
                           ..|:|.:|.::|..|:...:.....: ..|.:||.||.|:.::|:.||.|
  Fly  1058 ---------------FQAAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPAT 1107

Mouse   986 IFDFIQLVFIVIGAIIVVSALQPYIFLAT-VPGLVVFILLRAYFLHTAQQLKQLESEGRSPIFTH 1049
            :..|:..:|:|:..|:|:|...| ||||. ||...::...:.:::.|::||.:|||..||||::|
  Fly  1108 MDSFMTFIFMVLATIVVISLSTP-IFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSH 1171

Mouse  1050 LVTSLKGLWTLRAFR-RQTYFETLFHKALNLHTANWFMYLATLRWFQMRIDMIFVLFFIVVTFIS 1113
            ...::.|..|:||:. ...:.|....|........:...:|. ||..:|::|:..|..:..:..:
  Fly  1172 FSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIAN-RWLAIRLEMVGNLIILFASLFA 1235

Mouse  1114 ILTTGEGEGTAGIILTLAMNIMSTLQWAVNSSIDTDSLMRSVSRVFKFIDIQTEESMYTQIIKEL 1178
            :|......|..|:.::.|:.:..||.|.|..|.|.::.:.||.|:          ..|.:..:|.
  Fly  1236 VLGGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERI----------KEYGETKQEA 1290

Mouse  1179 PREGSSDVLVIKNEHVKKSDIWPSGGEMVVKDLTVKYMDDGNAVLENISFSISPGQRVGLLGRTG 1243
            |.|...|    ||    |...||..|.:..::..|:|.:..:.||..:||:|..|::||::||||
  Fly  1291 PWELEQD----KN----KPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTG 1347

Mouse  1244 SGKSTLLSAFLRMLNIKGD-IEIDGVSWNSVTLQEWRKAFGVITQKVFIFSGTFRQNLDPNGKWK 1307
            :|||:|..|..|::...|. |.||||...|:.|...|....:|.|...:|||:.|.||||.....
  Fly  1348 AGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKT 1412

Mouse  1308 DEEIWKVADEVGLKSVIEQFPGQLNFTLVDGGYVLSHGHKQLMCLARSVLSKAKIILLDEPSAHL 1372
            |:||||..:...|||.::.....||..:.:||..||.|.:||:||||::|.|.|:::|||.:|.:
  Fly  1413 DDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAV 1477

Mouse  1373 DPITYQVIRRVLKQAFAGCTVILCEHRIEAMLDCQRFLVIEESNVWQYDSLQALL-SEKSIF 1433
            |..|..:|::.::..|..|||:...||:..:||..:.:|:::..:.::.|...|| :.||.|
  Fly  1478 DLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAF 1539

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CftrNP_066388.1 CFTR_protein 1..1464 CDD:273530 386/1492 (26%)
ABC_membrane 85..303 CDD:294371 56/217 (26%)
ABCC_CFTR1 389..670 CDD:213258 88/283 (31%)
CFTR_R 639..844 CDD:291094 26/209 (12%)
Disordered R region. /evidence=ECO:0000250|UniProtKB:P13569 654..826 25/176 (14%)
ABC_membrane 861..1142 CDD:279056 72/292 (25%)
ABCC_CFTR2 1204..1464 CDD:213256 86/232 (37%)
Interaction with GORASP2. /evidence=ECO:0000250|UniProtKB:P13569 1382..1476 15/53 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1446..1476
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P13569 1474..1476
MRPNP_723772.2 MRP_assoc_pro 14..1548 CDD:188098 386/1492 (26%)
ABC_membrane 338..601 CDD:279056 64/262 (24%)
ABCC_MRP_domain1 649..848 CDD:213217 81/202 (40%)
ABC_membrane 988..1260 CDD:279056 70/295 (24%)
ABCC_MRP_domain2 1308..1528 CDD:213211 80/219 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167841708
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.840

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