DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF792 and CG31441

DIOPT Version :9

Sequence 1:	NP_787068.3	Gene:	ZNF792 / 126375	HGNCID:	24751	Length:	632	Species:	Homo sapiens
Sequence 2:	NP_731558.1	Gene:	CG31441 / 326139	FlyBaseID:	FBgn0051441	Length:	341	Species:	Drosophila melanogaster

Alignment Length:	413	Identity:	95/413 - (23%)
Similarity:	145/413 - (35%)	Gaps:	139/413 - (33%)

- Green bases have known domain annotations that are detailed below.

Human   125 TLCPQKTCPCDICGLRLKDILHLAEHQTTHPRQKPFVCEAYVKGSEFSANLPRKQVQQNVHNPIR 189
            |..|...|.|  |.::|..||..        |.|   | ..|..|..:||  ||.:::..   |.
  Fly    49 TTLPHLICQC--CKVQLDRILTF--------RNK---C-LEVHKSFMAAN--RKLLRKKA---IV 94

Human   190 TEEGQASPVKTCR----DHTSDQLSTCREGGKDFVATAGFLQCEVTPSDGEPHEATEGVVDFHIA 250
            .||.....|:..:    |||..::...      ...|||.|:        |.|...|
  Fly    95 DEELDKPDVEKLQQDLWDHTDQEMCVA------MADTAGLLR--------EDHNDNE-------- 137

Human   251 LRHNKCCESGDAFNNKSTLVQHQRIHSRERPYECSKCGIFFTYAADLTQH--QKVHNRGKPYECC 313
                |..::.||..|:....:..::.:.|                  .:|  :::||.
  Fly   138 ----KAKDAEDATQNEKNQEEQVQVQTEE------------------VEHCQEQLHNM------- 173

Human   314 ECGKFFSQHSSLVKHRRVHTGESPHVCGDCGKFFSRSSNLIQHKRVHTGEKPYECSDC-GKFFSQ 377
               ...|:..|....:|.........|..||..|..|:.|..|.:.|:|.||:.|..| .|:::.
  Fly   174 ---SIISKGVSARVPKRTKRNSKSWFCDQCGGVFKSSTYLKLHLQRHSGHKPFACDICQAKYYTD 235

Human   378 RSNLIHHKRVHTGRSAHECSECGKSFNCNSSLIKHWRVHTGERPYKCNECGKFFSHIASLIQHQI 442
                                                           ||          :.:|:|
  Fly   236 -----------------------------------------------NE----------MRRHRI 243

Human   443 VHTGERPHGCGECGKAFSRSSDLMKHQRVHTGERPYECNECGKLFSQSSSLNSHRRLHTGERPYQ 507
            :||..||:.|..|.|.:...|..:.|:|.||.|||::|..|.|.|:.:|:...|..|||.:|.|.
  Fly   244 LHTDARPYACRFCSKTYRGCSSKVVHERTHTNERPFQCQHCDKAFTSTSTRQKHEMLHTNQRKYH 308

Human   508 CSECGKFFNQSSSLNNHR--RLH 528
            |..|.::|.:||.|..|:  :||
  Fly   309 CEICDQWFLRSSHLTLHQSTKLH 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF792	NP_787068.3	KRAB	14..74	CDD:214630
		KRAB	14..53	CDD:279668
		C2H2 Zn finger	256..276	CDD:275368	3/19 (16%)
		C2H2 Zn finger	284..304	CDD:275368	1/21 (5%)
		C2H2 Zn finger	312..332	CDD:275368	3/19 (16%)
		zf-H2C2_2	324..349	CDD:290200	6/24 (25%)
		C2H2 Zn finger	340..360	CDD:275368	7/19 (37%)
		COG5048	<348..592	CDD:227381	49/184 (27%)
		zf-H2C2_2	352..377	CDD:290200	9/25 (36%)
		C2H2 Zn finger	368..388	CDD:275368	3/20 (15%)
		C2H2 Zn finger	396..416	CDD:275368	0/19 (0%)
		C2H2 Zn finger	424..444	CDD:275368	4/19 (21%)
		C2H2 Zn finger	452..472	CDD:275368	6/19 (32%)
		zf-H2C2_2	464..489	CDD:290200	11/24 (46%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		zf-H2C2_2	492..517	CDD:290200	9/24 (38%)
		C2H2 Zn finger	508..528	CDD:275368	7/21 (33%)
		zf-H2C2_2	520..545	CDD:290200	4/11 (36%)
		C2H2 Zn finger	536..556	CDD:275368
		zf-H2C2_2	548..573	CDD:290200
		C2H2 Zn finger	564..584	CDD:275368
CG31441	NP_731558.1	zf-AD	7..82	CDD:285071	13/46 (28%)
		COG5048	<174..337	CDD:227381	56/215 (26%)
		C2H2 Zn finger	197..217	CDD:275370	7/19 (37%)
		C2H2 Zn finger	225..245	CDD:275368	7/76 (9%)
		C2H2 Zn finger	253..273	CDD:275368	6/19 (32%)
		zf-H2C2_2	268..290	CDD:290200	11/21 (52%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		C2H2 Zn finger	309..328	CDD:275368	7/18 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000