DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF792 and Zfp397

DIOPT Version :9

Sequence 1:	NP_787068.3	Gene:	ZNF792 / 126375	HGNCID:	24751	Length:	632	Species:	Homo sapiens
Sequence 2:	NP_001258404.1	Gene:	Zfp397 / 100909408	RGDID:	6504280	Length:	527	Species:	Rattus norvegicus

Alignment Length:	518	Identity:	194/518 - (37%)
Similarity:	277/518 - (53%)	Gaps:	109/518 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   129 QKTC------PCDICGLRLKDILHLAEHQTTHPRQKPFVCEAYVKGSEFSANLPRK---QVQQNV 184
            :|.|      |.:..| ||:::.|.......|.:::  :.|..|. .:|.:.||.:   .|||
  Rat    54 RKFCYHETPGPREALG-RLQELCHQWLMPELHTKEQ--ILELLVL-EQFLSILPEELKIWVQQ-- 112

Human   185 HNPIRTEE---------------GQASP---------------VKTCRDHTSDQLSTCREGGKDF 219
            |.|...||               ||..|               ::|.:|.||.|:...:...|
  Rat   113 HGPKSGEEVVTLLEDLEKEFDDPGQQVPDNPQGPSVSWKDLTYLRTSQDSTSIQVRPLKTQLK-- 175

Human   220 VATAGFLQCEVTPSDGEPHEAT--EGVVD-----------FHIALRHNKCCESGDAFNNKST--- 268
                .:..|..:.:|.:.:|.|  |.:.:           |.....|....|    :..:|:
  Rat   176 ----SWKPCLSSKNDSKNNETTAKEDISEEKAPEFSWDPSFRGVSEHKSNLE----WQQRSSPLH 232

Human   269 -------LVQHQRIHSRERPYECSKCGIFFTYAADLTQHQKVHNRGKPYECCECGKFFSQHSSLV 326
                   :..|:.:..|:...|..:|.|..|.:...   |||....:||.|..||..|.||.||.
  Rat   233 RGSFSQVIFTHKSLAKRDHHDESQRCLILSTNSVTC---QKVSTDDRPYRCDVCGHSFKQHFSLT 294

Human   327 KHRRVHTGESPHVCGDCGKFFSRSSNLIQHKRVHTGEKPYECSDCGKFFSQRSNLIHHKRVHTGR 391
                                        ||:|:|||||||:|:.|||.||.||.||.|:::|:|.
  Rat   295 ----------------------------QHQRIHTGEKPYKCNQCGKAFSLRSYLIIHQKIHSGE 331

Human   392 SAHECSECGKSFNCNSSLIKHWRVHTGERPYKCNECGKFFSHIASLIQHQIVHTGERPHGCGECG 456
            .|:||:||||:||.:|:|.:|.::||||:..|||||||.||..:.||.||.:||||:|:.|.|||
  Rat   332 KAYECNECGKAFNQSSALTRHRKIHTGEKACKCNECGKAFSQSSYLIIHQRIHTGEKPYRCNECG 396

Human   457 KAFSRSSDLMKHQRVHTGERPYECNECGKLFSQSSSLNSHRRLHTGERPYQCSECGKFFNQSSSL 521
            |.||:||.|::|||:||||||||||||||.|.|||.|.:|:|:|:||:||:|:||||.|:.:|:|
  Rat   397 KTFSQSSKLIRHQRIHTGERPYECNECGKAFKQSSELITHQRIHSGEKPYECNECGKAFSLNSNL 461

Human   522 NNHRRLHTGERPYECSECGKTFRQRSNLRQHLKVHKPDRPYECSECGKAFNQRPTLIRHQKIH 584
            ..|:|:|:||.||:|::|||||::.|.|.||.::|..|..|.|:||||||..|..|:|||::|
  Rat   462 IRHQRIHSGEEPYQCNDCGKTFKRSSALVQHQRIHSGDEAYICNECGKAFRHRSVLMRHQRVH 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF792	NP_787068.3	KRAB	14..74	CDD:214630
		KRAB	14..53	CDD:279668
		C2H2 Zn finger	256..276	CDD:275368	3/29 (10%)
		C2H2 Zn finger	284..304	CDD:275368	5/19 (26%)
		C2H2 Zn finger	312..332	CDD:275368	8/19 (42%)
		zf-H2C2_2	324..349	CDD:290200	2/24 (8%)
		C2H2 Zn finger	340..360	CDD:275368	3/19 (16%)
		COG5048	<348..592	CDD:227381	137/237 (58%)
		zf-H2C2_2	352..377	CDD:290200	15/24 (63%)
		C2H2 Zn finger	368..388	CDD:275368	11/19 (58%)
		C2H2 Zn finger	396..416	CDD:275368	10/19 (53%)
		C2H2 Zn finger	424..444	CDD:275368	12/19 (63%)
		C2H2 Zn finger	452..472	CDD:275368	13/19 (68%)
		zf-H2C2_2	464..489	CDD:290200	19/24 (79%)
		C2H2 Zn finger	480..500	CDD:275368	13/19 (68%)
		zf-H2C2_2	492..517	CDD:290200	14/24 (58%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		zf-H2C2_2	520..545	CDD:290200	14/24 (58%)
		C2H2 Zn finger	536..556	CDD:275368	10/19 (53%)
		zf-H2C2_2	548..573	CDD:290200	13/24 (54%)
		C2H2 Zn finger	564..584	CDD:275368	12/19 (63%)
Zfp397	NP_001258404.1	SCAN	46..152	CDD:128708	23/103 (22%)
		COG5048	<264..520	CDD:227381	146/286 (51%)
		C2H2 Zn finger	280..300	CDD:275368	11/47 (23%)
		C2H2 Zn finger	308..328	CDD:275368	11/19 (58%)
		C2H2 Zn finger	336..356	CDD:275368	10/19 (53%)
		C2H2 Zn finger	364..384	CDD:275368	12/19 (63%)
		C2H2 Zn finger	392..412	CDD:275368	13/19 (68%)
		C2H2 Zn finger	420..440	CDD:275368	13/19 (68%)
		C2H2 Zn finger	448..468	CDD:275368	10/19 (53%)
		C2H2 Zn finger	476..496	CDD:275368	10/19 (53%)
		C2H2 Zn finger	504..524	CDD:275368	12/19 (63%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910