DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PLK3 and CDC5

DIOPT Version :9

Sequence 1:NP_004064.2 Gene:PLK3 / 1263 HGNCID:2154 Length:646 Species:Homo sapiens
Sequence 2:NP_013714.1 Gene:CDC5 / 855013 SGDID:S000004603 Length:705 Species:Saccharomyces cerevisiae


Alignment Length:655 Identity:208/655 - (31%)
Similarity:328/655 - (50%) Gaps:66/655 - (10%)


- Green bases have known domain annotations that are detailed below.


Human    39 EMLAGLPTSDPGRLITDPRSGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQ 103
            |.|:.|..:.|..:.|   .|:.|.:|..||:||||||::..| ::|..:|.|.:.::.:.....
Yeast    62 EKLSALCKTPPSLIKT---RGKDYHRGHFLGEGGFARCFQIKD-DSGEIFAAKTVAKASIKSEKT 122

Human   104 REKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQ 168
            |:|:|:||::|:.:.|.:||:|...|||..|:||.||:|...||..:.|.|..|.|||||::..|
Yeast   123 RKKLLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPNGSLMELLKRRKVLTEPEVRFFTTQ 187

Human   169 ILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL 233
            |...:||:|.|.::||||||||.|...|..||:|||||||.|....:||.||||||||:|||||:
Yeast   188 ICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESERKYTICGTPNYIAPEVLM 252

Human   234 --RQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPAS--LSLPARQLLAAI 294
              ..||..|.|:||||.::|.||.|.|||:..|:...|..||...::.|..  :|...:.|:..|
Yeast   253 GKHSGHSFEVDIWSLGVMLYALLIGKPPFQARDVNTIYERIKCRDFSFPRDKPISDEGKILIRDI 317

Human   295 LRASPRDRPSIDQILRHDFFTKGYTPDRLPISSCVTVPDLTPPNPARSL--FAK-VTKSLFGRKK 356
            |...|.:|||:.:|:.:.:| :|..|..:|.:.....|:.......:||  |.. :.|||.....
Yeast   318 LSLDPIERPSLTEIMDYVWF-RGTFPPSIPSTVMSEAPNFEDIPEEQSLVNFKDCMEKSLLLESM 381

Human   357 KS-KNHAQERDEVSGLVSGLMRTSVGHQDARPEAPAASGP----------------------APV 398
            .| |...|:||.:|.:.|.:.:....||: ||..|.:..|                      |..
Yeast   382 SSDKIQRQKRDYISSIKSSIDKLEEYHQN-RPFLPHSLSPGGTKQKYKEVVDIEAQRRLNDLARE 445

Human   399 SLVETAPEDSSPRGTLASSGDGFEEGLTVATVVESALCALRNCIAFMPPAEQNPAPLAQ----PE 459
            :.:..|.:....:..:|:|.:..:..:::..:.......|...:......:....|.::    ..
Yeast   446 ARIRRAQQAVLRKELIATSTNVIKSEISLRILASECHLTLNGIVEAEAQYKMGGLPKSRLPKIKH 510

Human   460 PLVWVSKWVDYSNKFGFGYQLSSRRVAVLFNDGTHMALSANRKTVHYNPTSTK------HFSFSV 518
            |:: |:||||||||.||.||||:..:.||||:||.:...|:.:...|.....:      |:..| 
Yeast   511 PMI-VTKWVDYSNKHGFSYQLSTEDIGVLFNNGTTVLRLADAEEFWYISYDDREGWVASHYLLS- 573

Human   519 GAVPRALQPQLGILRYFASYMEQHLMK----GGDLPSVEEVEVPAPPLLLQWVKTDQALLMLFSD 579
             ..||.|...|.::.:||.||:.:|.:    |.:....::|      .|.::.:....::...||
Yeast   574 -EKPRELSRHLEVVDFFAKYMKANLSRVSTFGREEYHKDDV------FLRRYTRYKPFVMFELSD 631

Human   580 GTVQVNFYGDHTKLILSGWEPLLVTFVARNRSACTYLASHLRQLGCSP-----DLRQRLRYALRL 639
            ||.|.||...|...|..|.:  |||:::.:..:.||....:.:.|..|     :.|::|......
Yeast   632 GTFQFNFKDHHKMAISDGGK--LVTYISPSHESTTYPLVEVLKYGEIPGYPESNFREKLTLIKEG 694

Human   640 LRDRS 644
            |:.:|
Yeast   695 LKQKS 699

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PLK3NP_004064.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..35
STKc_PLK3 60..314 CDD:271091 113/257 (44%)
S_TKc 62..314 CDD:214567 113/255 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 381..417 9/57 (16%)
POLO_box_1 460..548 CDD:240561 36/97 (37%)
POLO_box_2 561..628 CDD:240560 18/71 (25%)
CDC5NP_013714.1 STKc_PLK 80..337 CDD:271001 113/257 (44%)
POLO_box_1 510..601 CDD:240561 35/93 (38%)
POLO_box_2 613..698 CDD:240560 22/92 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 257 1.000 Domainoid score I359
eggNOG 1 0.900 - - E1_KOG0575
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 354 1.000 Inparanoid score I446
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000754
OrthoInspector 1 1.000 - - otm52722
orthoMCL 1 0.900 - - OOG6_100759
Panther 1 1.100 - - O PTHR24345
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R930
SonicParanoid 1 1.000 - - X638
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1211.850

Return to query results.
Submit another query.