Protein Alignment PLK3 and Plk3

DIOPT Version :10

• Sequence 1: NP_004064.2
• Gene: PLK3 / 1263
• HGNCID: 2154
• Length: 646
• Species: Homo sapiens
• Sequence 2: NP_038835.2
• Gene: Plk3 / 12795
• MGIID: 109604
• Length: 648
• Species: Mus musculus
• Alignment Length: 648
• Identity: 604/648 - (93%)
• Similarity: 620/648 - (95%)
• Gaps: 2/648 - (0%)

Human     1 MEPAAGFLSPRPFQRAAAAPAPPAGPGPPPSALRGPELEMLAGLPTSD-PGRLITDPRSGRTYLK 64
            |||||||||||||.||||..|||||||||.:|....|.|:|||....| ||||||||.|||||.|
Mouse     1 MEPAAGFLSPRPFPRAAAPSAPPAGPGPPANASPRSEPEVLAGPRAPDPPGRLITDPLSGRTYTK 65

Human    65 GRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHF 129
            |||||||||||||||||||:|.|||||||||||||||||||||||||||||||||||||||||||
Mouse    66 GRLLGKGGFARCYEATDTESGIAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHF 130

Human   130 EDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFIT 194
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 EDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFIT 195

Human   195 ENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPP 259
            :||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 DNMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPP 260

Human   260 FETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYTPDRLP 324
            ||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||
Mouse   261 FETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIEQILRHDFFTKGYTPDRLP 325

Human   325 ISSCVTVPDLTPPNPARSLFAKVTKSLFGRKK-KSKNHAQERDEVSGLVSGLMRTSVGHQDARPE 388
            :||||||||||||||||||||||||||||||| |:|||::::|.||.|||||||||:||.|.|||
Mouse   326 VSSCVTVPDLTPPNPARSLFAKVTKSLFGRKKNKNKNHSEDQDNVSCLVSGLMRTSIGHPDVRPE 390

Human   389 APAASGPAPVSLVETAPEDSSPRGTLASSGDGFEEGLTVATVVESALCALRNCIAFMPPAEQNPA 453
            ||..||.||.||||||.||||||||||||||||||||||||||||||||||||:|||||||||||
Mouse   391 APVVSGQAPASLVETAAEDSSPRGTLASSGDGFEEGLTVATVVESALCALRNCVAFMPPAEQNPA 455

Human   454 PLAQPEPLVWVSKWVDYSNKFGFGYQLSSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSV 518
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:
Mouse   456 PLAQPEPLVWVSKWVDYSNKFGFGYQLSSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSM 520

Human   519 GAVPRALQPQLGILRYFASYMEQHLMKGGDLPSVEEVEVPAPPLLLQWVKTDQALLMLFSDGTVQ 583
            |:||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||
Mouse   521 GSVPRALQPQLGILRYFASYMEQHLMKGGDLPSVEEAEVPAPPLLLQWVKTDQALLMLFSDGTVQ 585

Human   584 VNFYGDHTKLILSGWEPLLVTFVARNRSACTYLASHLRQLGCSPDLRQRLRYALRLLRDRSPA 646
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||
Mouse   586 VNFYGDHTKLILSGWEPLLVTFVARNRSACTYLASHLRQLGCSPDLRQRLRYALRLLRDQSPA 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLK3	NP_004064.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..35		27/33 (82%)
		STKc_PLK3	60..314	CDD:271091	248/253 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	381..417		28/35 (80%)
		POLO_box_1	460..548	CDD:240561	85/87 (98%)
		POLO_box_2	561..628	CDD:240560	66/66 (100%)
Plk3	NP_038835.2	STKc_PLK3	61..315	CDD:271091	248/253 (98%)
		POLO_box_1	462..550	CDD:240561	85/87 (98%)
		POLO_box_2	563..630	CDD:240560	66/66 (100%)