DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ces1g and Nrt

DIOPT Version :9

Sequence 1:	NP_067431.2	Gene:	Ces1g / 12623	MGIID:	88378	Length:	565	Species:	Mus musculus
Sequence 2:	NP_001189121.1	Gene:	Nrt / 39873	FlyBaseID:	FBgn0004108	Length:	846	Species:	Drosophila melanogaster

Alignment Length:	571	Identity:	142/571 - (24%)
Similarity:	235/571 - (41%)	Gaps:	130/571 - (22%)

- Green bases have known domain annotations that are detailed below.

Mouse    17 LGHPSL--PPVVHTVHGKVLGKYV-------TLEGFSQPVA-VFLGVPFAKPPLGSLRFAPPEPA 71
            |.|.:|  ||:..       |:|:       .:||..:..| .|.|:|:||||:..||:.|.|..
  Fly   345 LTHETLTSPPLRE-------GRYIMAVTGCGPVEGVKEDGAFAFRGIPYAKPPVDRLRWKPAELI 402

Mouse    72 EP----WSFVKHTTSYPPLCYQNPEAALRLAELFTNQRKIIPHKFSEDCLYLNIYTPADLTQNSR 132
            :.    |:....|.:...:|.|.......:.:              ||||||::.|| .:..|:.
  Fly   403 DDINMCWNDTLQTHNSSVVCTQRLGNGTTVGD--------------EDCLYLDVVTP-HVRYNNP 452

Mouse   133 LPVMVWIHGGGLVIDGASTYDGV--PLAVH---ENVVVVVIQYRLGIWGFFS----TEDEH--SR 186
            |||:|.|....|    |....|:  |.|.:   .:|:.|...:|||::||.:    |::.|  :.
  Fly   453 LPVVVLIGAESL----AGPSPGILRPSARYSRSHDVIFVRPNFRLGVFGFLALDALTKEAHPPTS 513

Mouse   187 GNWGHLDQVAALHWVQDNIANFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAIAQSSVIF 251
            ||:...|.:|.|:|::.||.:|||:|.|||:.|..||...|::||.|...|.|:.||.|.|....
  Fly   514 GNYALTDIIAVLNWIKLNIVHFGGDPQSVTLLGHRAGATLVTLLVNSQKVKGLYTRAWASSGSAI 578

Mouse   252 NPCLFGRAARPLAKKIAALAGCKTTTSAAMVHCLRQKTEDELLEVS--LKMKFGTVDFLGDPRES 314
            .|      .:||::..........|...|.:.|||:.:.:.|...:  ..:.| .|| |..|:|:
  Fly   579 LP------GKPLSESGKQNEQLMATLECADIQCLREASSERLWAATPDTWLHF-PVD-LPQPQEA 635

Mouse   315 ------YPFLPTVIDGVLLPKAPEEILAEKSFNTVPYMV-GINKHEFGWIIPMFLDFPLSERKLD 372
                  :.:|  |:||.::.:.|.:....:..|..|.:| |...||            ....||.
  Fly   636 NASGSRHEWL--VLDGDVVFEHPSDTWKREQANDKPVLVMGATAHE------------AHTEKLR 686

Mouse   373 QKTAASILW-----QAYPILNISE----KLIPAAIEKYLGGTEDPATMTDLFLDLIGDIMFGVPS 428
            :..|.   |     :||  |..|:    .|....||||      .|:.....:.:|.||....|
  Fly   687 ELHAN---WTREEVRAY--LENSQIGALGLTDEVIEKY------NASSYASLVSIISDIRSVCP- 739

Mouse   429 VIVSRSHRDAGAPTYMYEYQYRPSFVS--DDRPQELLGDH-------------ADELFSVWGAPF 478
             :::.:.:....|.|:......|..::  |...|.:||.:             ..:||..    :
  Fly   740 -LLTNARQQPSVPFYVVTQGEGPDQLATVDADVQAILGRYEPHTVEQRRFVSAMQQLFYY----Y 799

Mouse   479 LKEGASEEEINLSKMVMKFWANFARNGNPNGEGLP--HWPEYDQKEGYLQI 527
            :..|..:..:...:::     |..::..|..:.||  :|...|....|.::
  Fly   800 VSHGTVQSFVQNRRVI-----NVGQDAQPEEDYLPCNYWISKDIVPRYARV 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ces1g	NP_067431.2	COesterase	24..545	CDD:278561	138/562 (25%)
Ces1g	NP_067431.2	Aes	<121..>239	CDD:223730	45/128 (35%)
Nrt	NP_001189121.1	Abhydrolase	362..832	CDD:304388	132/532 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910