DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CNGA4 and CG42260

DIOPT Version :9

Sequence 1:	XP_016872706.1	Gene:	CNGA4 / 1262	HGNCID:	2152	Length:	577	Species:	Homo sapiens
Sequence 2:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster

Alignment Length:	472	Identity:	195/472 - (41%)
Similarity:	294/472 - (62%)	Gaps:	8/472 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     8 KTTESSPPAPSKARKLLPVLDPSGDYYYWWLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVL 72
            :|......|.:.||||..|.||:|...|:|...:....:||..:::.|..|.::....:..|..|
  Fly   554 RTASQRIRAATAARKLHFVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCL 618

Human    73 DYTSDLLYLLDMVVRFHTGFLEQGILVVDKGRISSRYVRTWSFFLDLASLMPTDVVYVRLGPHTP 137
            ||.||.|||:|::..|.||:||.|:|..|..::.:.|:.:..|::|...|:|.|.:|:.:| ...
  Fly   619 DYLSDFLYLIDILFHFRTGYLEDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYLSIG-FNS 682

Human   138 TLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVIHWNSCLYFALSRYLGFGRDAWV 202
            .||..|.::..|.:...||||..|.|||.||...|:.|:.|:.|||.|||..:.:..|||...||
  Fly   683 ILRSFRLVKIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIFHWNGCLYHIIHKNNGFGSRNWV 747

Human   203 YPDPAQPGFERLRRQYLYSFYFSTLILTTVGDTPPPAREEEYLFMVGDFLLAVMGFATIMGSMSS 267
            |.|.....   :.:|||.|:|:.||.|||:||.|.|..:.||:|::...|..:|.|||::|.:::
  Fly   748 YHDSESAD---VVKQYLQSYYWCTLALTTIGDLPKPRSKGEYVFVILQLLFGLMLFATVLGHVAN 809

Human   268 VIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRA 332
            ::.:::.|...|......||.||:::.|...|:.:||.|:.:|.:.:|.::|...:..||::|:|
  Fly   810 IVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKA 874

Human   333 EVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVA 397
            |:|::|||.||.||:||||.||..|.||||:|:|..:|||:|:||||::|:||||:..|:|.|||
  Fly   875 EIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVA 939

Human   398 DDGITQYAVLGAGLYFGEISIINIKATGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQA 462
            |:|.|..|.|.||.|||||||:|:    ..:||||||:::|:||||||.|||:|:.:||.|||.|
  Fly   940 DNGKTVMASLKAGSYFGEISILNM----GTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAA 1000

Human   463 QTIMEEKGREILLKMNK 479
            :..:|....:.|.|..|
  Fly  1001 RVRLESIAVKRLEKYKK 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNGA4	XP_016872706.1	None
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	86/241 (36%)
		CAP_ED	890..1004	CDD:237999	69/117 (59%)
		DUF4655	1084..>1154	CDD:317882
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100817
Panther	1	1.100	-	-	O	PTHR45638
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820