DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cenpb and cag

DIOPT Version :9

Sequence 1:	NP_031708.2	Gene:	Cenpb / 12616	MGIID:	88376	Length:	599	Species:	Mus musculus
Sequence 2:	NP_001260876.1	Gene:	cag / 36157	FlyBaseID:	FBgn0017414	Length:	225	Species:	Drosophila melanogaster

Alignment Length:	134	Identity:	47/134 - (35%)
Similarity:	81/134 - (60%)	Gaps:	12/134 - (8%)

- Green bases have known domain annotations that are detailed below.

Mouse     5 RRQLTFREKSRIIQEVEENPDLRKGEIARRFNIPPSTLSTILKNKRAILASERKYGVASTCRKTN 69
            |..||..||..:||..|.| .|...::|:||||..:..:.|||:|::|     |.|:.|...|.|
  Fly    10 RTSLTLEEKMEVIQSQERN-KLSVRDLAKRFNIGKTQAADILKHKQSI-----KEGLLSGELKLN 68

Mouse    70 KL--SPYD----KLEGLLIAWFQQIRAAGLPVKGIILKEKALRIAEELGMDDFTASNGWLDRFRR 128
            ::  :|..    :::.:...||.::|...:|:.|.::::||.::|.|||..:|:||:|||:::|:
  Fly    69 QMRRNPLSQRGAQIDEMCFDWFSRVRTENIPISGEMVRKKAKQLAVELGHSNFSASSGWLEKWRK 133

Mouse   129 RHGV 132
            ||.|
  Fly   134 RHNV 137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cenpb	NP_031708.2	CENP-B_N	2..56	CDD:282122	20/50 (40%)
		CENPB	74..135	CDD:197828	21/63 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..183
		DDE_1	222..384	CDD:281213
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..476
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..543
		Homodimerization. /evidence=ECO:0000250	536..599
		CENP-B_dimeris	<539..598	CDD:286159
cag	NP_001260876.1	CENP-B_N	7..60	CDD:282122	21/55 (38%)
cag	NP_001260876.1	CENPB	78..141	CDD:197828	21/60 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I10787
eggNOG	1	0.900	-	-		E1_KOG3105
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1343623at2759
OrthoFinder	1	1.000	-	-		FOG0000365
OrthoInspector	1	1.000	-	-		otm42505
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.850