Protein Alignment NTN5 and NetB

DIOPT Version :10

• Sequence 1: NP_665806.1
• Gene: NTN5 / 126147
• HGNCID: 25208
• Length: 489
• Species: Homo sapiens
• Sequence 2: NP_511155.1
• Gene: NetB / 32400
• FlyBaseID: FBgn0015774
• Length: 793
• Species: Drosophila melanogaster
• Alignment Length: 785
• Identity: 183/785 - (23%)
• Similarity: 272/785 - (34%)
• Gaps: 321/785 - (40%)

Human     1 MPVTFALLL---LLGQATADPCYDPQGRPQFCLP---------PVTQLAAVAASCPQA-CALSPG 52
            :|:..||.:   ..|.::.||||. :|:|:.|||         ||...:...|..|:. |.|...
  Fly    13 LPIILALAIGSSAAGISSNDPCYF-EGKPRKCLPSFVNAAYGNPVQASSVCGAQQPERYCELLRD 76

Human    53 NHLGARETC---------------------------------------NGSLTLALGGPFLLTSV 78
            .:.|...:|                                       |.:|||:||..:.||.:
  Fly    77 GNAGECRSCEQQRYGPAALTDLNNPSNVTCWRSGAVNVPHDPDSAPPDNVTLTLSLGKKYELTYI 141

Human    79 SLRFC--TPGPPALILSAAWASGGPW--------------------------------------- 102
            ||.||  :|.|.:|.:..:...|..|
  Fly   142 SLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRPDRAKISKFNEQEARCINSQHDT 206

Human   103 ------------------------------------RLLWHR----------------------- 108
                                                |:::||
  Fly   207 GGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRVVFHRLELPPQLLKVKNANAFSDEMGGS 271

Human   109 ----------------------------------------------------------------- 108
                                                                             
  Fly   272 REEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLELDDDHLHLDYASDGESVVKR 336

Human   109 ----------------------PAWPGALGGPERVTFHSTPGPKATVAASHLRVEFGGQAGLAAA 151
                                  |..|..:..|.:||..||..|.|  |||.:.:.......::..
  Fly   337 QGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSA--AASAVTLPISQHYAVSDF 399

Human   152 GLRGRCQCHGHAARCAAR---------------------ARPP-----------------RCHCR 178
            .:.|||:|:|||:.|.|.                     :.|.                 .|.|:
  Fly   400 AVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHFGRSTQMSAKLTMTCACK 464

Human   179 HHTTGPGCESCRPSHRDWPWRPATPRHPHPCLPCSCNQHARRCRFNSELFRLSGGRSGGVCERCR 243
            |:|.||.||.|:|.:.|.||..||....:.|..|.||.||||||||.||::|||..|||||..|:
  Fly   465 HNTAGPECERCKPFYFDRPWGRATDNDANECKMCQCNGHARRCRFNLELYKLSGRVSGGVCYNCQ 529

Human   244 HHTAGRHCHYCQPGFWRDPSQPIFSRRACRACQCHPIGATGGTCNQTSGQCTCKLGVTGLTCNRC 308
            |.|.||:||||:.|::||.::|...|:.|:.|.|||:|:||.|||..||||.||.||||||||||
  Fly   530 HDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVGSTGKTCNHLSGQCPCKEGVTGLTCNRC 594

Human   309 GPGYQQSRSPRMPCQRIPEATTTLAT--------------TPGAYSSDPQCQNYC-NMSDTRVHM 358
            ..||||:||...||.::|.....:..              ..|..|...:.:.|| ....:...:
  Fly   595 ARGYQQTRSHVAPCIKVPTNANMIQAESAGGGGGGGTGDYKDGGGSQVEEMKKYCGKCKASPKKL 659

Human   359 SLRRYCQQDHVLRAQVLASEAAGPAWQRLAVRVLAVYKQ--------------RAQPVR------ 403
            :|.::|.:|:.:.|:|:..:.|.   |.::....::.:|              :..|:.
  Fly   660 NLNKFCMEDYAILAKVIGHDRAS---QDISTEKFSIERQNEIYKYEINIQTIFKRNPMSGTTSSL 721

Human   404 --RGDQDAWVPRADLTCGCLRLQPGTDYLLLGSAVGDPDPTRLILDRHGLALPWRPRWARPLKRL 466
              ||:....|||..:.|.|.:::....||:||.. .:..|..|.:....:.|.|:..|:..:||.
  Fly   722 LGRGNMMLLVPRKSIECQCPKIKLNKSYLILGRD-SEAAPGYLAIGPSSVVLEWKDEWSLRMKRF 785

Human   467 QQEER 471
            |:..|
  Fly   786 QRRAR 790

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NTN5	NP_665806.1	EGF_Lam	211..265	CDD:238012	33/53 (62%)
		EGF_Lam	274..323	CDD:238012	33/48 (69%)
		NTR_netrin-1_like	360..475	CDD:239634	29/134 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	470..489		1/2 (50%)
NetB	NP_511155.1	LamNT	37..261	CDD:214532	33/223 (15%)
		EGF_Lam	<458..484	CDD:238012	11/25 (44%)
		EGF_Lam	498..555	CDD:238012	34/56 (61%)
		EGF_Lam	560..608	CDD:238012	32/47 (68%)
		NTR_netrin-1_like	661..791	CDD:239634	29/134 (22%)