Protein Alignment Cel and alpha-Est2

DIOPT Version :9

• Sequence 1: NP_034015.1
• Gene: Cel / 12613
• MGIID: 88374
• Length: 599
• Species: Mus musculus
• Sequence 2: NP_001262345.1
• Gene: alpha-Est2 / 40908
• FlyBaseID: FBgn0015570
• Length: 566
• Species: Drosophila melanogaster
• Alignment Length: 574
• Identity: 160/574 - (27%)
• Similarity: 245/574 - (42%)
• Gaps: 95/574 - (16%)

Mouse    28 TEGGFVEGVNKKLSLLGGDSVDIFKGIPFATAKT----LENPQRHPGWQGTLKATNFKKRCLQAT 88
            |:.|.|.|:.:| ::...:....|:|||:|....    ...||....|||.|..|..:.:.:|..
  Fly    37 TKYGQVRGLQRK-TVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCTTNRSKPMQRN 100

Mouse    89 ITQDNTYGQEDCLYLNIWVPQGRKQVSHNLPVMVWIYGGAFLMGSGQGANFLKNYLYDGEEIATR 153
            :......|.||||:||::|...:.:  ..|||:||||||.|..|......:..:|.       .:
  Fly   101 MLLGIVEGSEDCLHLNVYVKALKSE--KPLPVIVWIYGGGFQKGEASRDIYSPDYF-------MK 156

Mouse   154 GNVIVVTFNYRVGPLGFLSTGDANL--PGNFGLRDQHMAIAWVKRNIAAFGGDPDNITIFGESAG 216
            ..|:.|..|||:..|||||..|..|  |||.||:||.||:.|:.:|||.|.|||:|||:.|||||
  Fly   157 KPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAHFNGDPNNITLMGESAG 221

Mouse   217 AASVSLQTLSPYNKGLIRRAISQSGMALSPWAIQKNPLFWAKTIAKKVGCP-TEDTGKMAACLKI 280
            :|||.:...:...:||..:||.|||.|||.| ::.....||..:|:.:|.. .|....:.:.|..
  Fly   222 SASVHVMMTTEQTRGLFHKAIMQSGCALSEW-VESPDNNWAFRLAQNLGYKGDEKDADVLSFLSK 285

Mouse   281 TDPRALTLAYKLPVKKQEYPVVHYLAFIPVI-----DGDFIPDDPINLYNNT--ADIDYIAGINN 338
            ...|.:....:..:...|.......||.|||     |...:|....:|.:..  .||..|.|.|:
  Fly   286 VCARQIAAIDQDVINLDEVRSFLLFAFGPVIEPYETDHCVVPKRHKDLLSEAWGNDIPVIVGGNS 350

Mouse   339 MDGHLFATIDVPAVDKTKQTVTEEDFYRLVSGHTV-------AKGLKGAQATFDIYTESWAQDPS 396
            .:| ||:           ..:..:|.:.|.:.|.:       ...|:|.    |:......|...
  Fly   351 FEG-LFS-----------YQLVRKDPWALKNFHNILPREVRETSSLEGQ----DLLVRRLKQLYF 399

Mouse   397 QENMKKTVVAFETDVLF-----LIPTEIALAQHKAHAKSAKTYSYLFSHPS-------RMPIYPK 449
            ...|::::..||...:|     ...|...:...:::|....||.|.|...|       |:....:
  Fly   400 NNEMQESMEMFEALNIFSHRQIWHDTHRFILARQSYAPKTPTYLYRFDFDSPHFNQFRRLVCGDR 464

Mouse   450 WMGADHADDLQYVFGKPFATPLGYRPQDRAVSKAMIAYWTNFARSGDPN---MGNSPVPTHWYPY 511
            ..|..|||:|.|:|....|:.|.....:....:.|:..||:||.||:||   :|::    .|
  Fly   465 IRGVAHADELSYLFYNIIASKLDKSSMEYKTIERMVGMWTSFASSGNPNCPELGSA----KW--- 522

Mouse   512 TLENGNYLDITKTITSASMKEHLREKFLKFWAVTFEVLPTVTGDQDTLTPPEDD 565
                          .:..:||:..||..           .::.|.:....||.|
  Fly   523 --------------EAVQLKENAVEKCF-----------NISHDLEMRDLPESD 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cel	NP_034015.1	COesterase	26..542	CDD:278561	156/549 (28%)
		Aes	<117..>247	CDD:223730	62/131 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	553..599		4/13 (31%)
		4 X 11 AA tandem repeats, O-glycosylated region	559..588		3/7 (43%)
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	152/533 (29%)
		Aes	<117..>221	CDD:223730	48/112 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832805
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.640