Protein Alignment CPT1C and ChAT

DIOPT Version :10

• Sequence 1: NP_001365411.1
• Gene: CPT1C / 126129
• HGNCID: 18540
• Length: 825
• Species: Homo sapiens
• Sequence 2: NP_477004.5
• Gene: ChAT / 42249
• FlyBaseID: FBgn0000303
• Length: 721
• Species: Drosophila melanogaster
• Alignment Length: 742
• Identity: 198/742 - (26%)
• Similarity: 312/742 - (42%)
• Gaps: 143/742 - (19%)

Human   120 FTLHVALRLLLSYHGWLLEPHGAMSSPTKTWLALVRIFSGRHPMLFSYQRSLPRQPVPSVQDTVR 184
            |..|....:..|..||   ....:|.| |.||:.......     |.:..:||:.|||::.:|:.
  Fly    46 FLTHRLSNITPSDTGW---KDSILSIP-KKWLSTAESVDE-----FGFPDTLPKVPVPALDETMA 101

Human   185 KYLESVRPILSDEDFDWTAVLAQEFLRLQ--ASLLQWYLRLKSWWASNYVSDWWEEFVYLRSRNP 247
            .|:.::.||.:....:.|..|.::|...|  .:.|..||..|.....|:...:|...:|:..|.|
  Fly   102 DYIRALEPITTPAQLERTKELIRQFSAPQGIGARLHQYLLDKREAEDNWAYYYWLNEMYMDIRIP 166

Human   248 LMVNSNYYM------------MAARAGNAVHALLLYRHRLNRQEIPPVRGPQWVRDGGVVLWPLG 300
            |.:|||..|            :|..|...:..:|.:|..|:..|:|..|.....::
  Fly   167 LPINSNPGMVFPPRRFKTVHDVAHFAARLLDGILSHREMLDSGELPLERAASREKN--------- 222

Human   301 HVGPGRQLTAHGFLQTLLMGMRPLCSAQYEKIFNTTRIPGVQKD--YI---RHLHD-SQHVAVFH 359
                                 :|||.|||.::..:.|.|||::|  ::   ..|:| .:||.|..
  Fly   223 ---------------------QPLCMAQYYRLLGSCRRPGVKQDSQFLPSRERLNDEDRHVVVIC 266

Human   360 RGRFFRMGTH-SRNSLLSPRALEQQFQRILDDPSPACPHEE-HLAALTAAPRGTWAQVRTSLKTQ 422
            |.:.:.:... |....||...:..|...:|.| :|..|.:. .:..|||.||.|||:.|..|:..
  Fly   267 RNQMYCVVLQASDRGKLSESEIASQILYVLSD-APCLPAKPVPVGLLTAEPRSTWARDREMLQED 330

Human   423 AAEA--LEAVEGAAFFVSLDAEP-------AGLTREDP----AASLDA--YAHALLAGRGHD--- 469
            ....  ||.:|.|...:.|| ||       .|.|...|    |...|.  .||.::.|.|.:
  Fly   331 ERNQRNLELIETAQVVLCLD-EPLAGNFNARGFTGATPTVHRAGDRDETNMAHEMIHGGGSEYNS 394

Human   470 --RWFDKSFTLIVFSNGKLGLSVEHSWADCPISGHMWEFTLATECFQLGYSTDGHCKGHPDPT-- 530
              |||||:..||:.::|..||..|||.::            .....||........:.|||..
  Fly   395 GNRWFDKTMQLIICTDGTWGLCYEHSCSE------------GIAVVQLLEKIYKKIEEHPDEDNG 447

Human   531 -----LPQPQRLQWDLPDQIHSSISLALRGAKILSENVDCHVVPFSLFGKSFIRRCHLSSDSFIQ 590
                 ||.|:||:|.:..|:....:.|.:......:::|.:|..:..:||:||:.|.:|.|.:||
  Fly   448 LPQHHLPPPERLEWHVGPQLQLRFAQASKSVDKCIDDLDFYVYRYQSYGKTFIKSCQVSPDVYIQ 512

Human   591 IALQLAHFRDRGQFCLTYESAMTRLFLEGRTETVRSCTREACNFVRAM--------------EDK 641
            :||||||::..|:...|||||.||.||.||.:.:|:.:.||..:.:||              ||:
  Fly   513 LALQLAHYKLYGRLVATYESASTRRFLHGRVDCIRAASTEALEWAKAMCQGEGANVPLESDREDE 577

Human   642 EK---------TDPQCLALFRVAVDKHQALLKAAMSGQGVDRHLFAL----YIVSRFLHLQSPFL 693
            |:         :......|||.||.:...::...:.|.|:|..|..|    ..|:..:|......
  Fly   578 EESRKVKFSIYSKDHLRELFRCAVARQTEVMVKNILGNGIDIPLLGLREASIEVTGEMHELFKDE 642

Human   694 TQVHSEQWQLSTSQIPVQQMHLFDVHNYPDYVSSGGGFGPADDHGYGVSYIFMGDGMITFHISSK 758
            :.:.|:.:.|||||:...             ..|..|:||....|||.||....: .|.|.:|:.
  Fly   643 SYIISQCFLLSTSQVACS-------------TDSFMGYGPVTPRGYGCSYNPHPE-QIVFCVSAF 693

Human   759 KSSTKTDSHRLGQHIEDALLDVASLFQ 785
            .|...|.:.|..:.::|:|..:..|.|
  Fly   694 YSCEDTSASRYAKSLQDSLDIMRDLLQ 720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CPT1C	NP_001365411.1	CPT_N	1..47	CDD:465132
		Carn_acyltransf	174..775	CDD:459926	181/676 (27%)
ChAT	NP_477004.5	Carn_acyltransf	92..710	CDD:459926	181/675 (27%)