Protein Alignment CPT1C and whd

DIOPT Version :10

• Sequence 1: NP_001365411.1
• Gene: CPT1C / 126129
• HGNCID: 18540
• Length: 825
• Species: Homo sapiens
• Sequence 2: NP_001163111.1
• Gene: whd / 36109
• FlyBaseID: FBgn0261862
• Length: 782
• Species: Drosophila melanogaster
• Alignment Length: 821
• Identity: 342/821 - (41%)
• Similarity: 478/821 - (58%)
• Gaps: 84/821 - (10%)

Human     1 MAEAHQAVGFRPSLTSDGAEVELSAPVLQEIYLSGLRSWKRHLSRFWNDFLTGVFPASPLSWLFL 65
            |||||.||.|..::|.:|.::.....||..::.||:||||:.|:|..|....||:||. :..|:|
  Fly     1 MAEAHAAVAFSFAITHEGFDINYDHEVLNLVWNSGVRSWKKRLARARNGVRNGVYPAH-IQSLWL 64

Human    66 FSAIQLA-WFLQLDPSLGLMEKIKELLP----DWGGQHHGLRGVLAAALFASCLWGALIFTLHVA 125
            .|||.|. .|........|..:|...||    :|        .|.|..|.|..:|.::.||:...
  Fly    65 ISAIALGLHFAGYQAPFNLTNRILVHLPSNTINW--------QVTACFLAALVVWLSICFTMRYT 121

Human   126 LRLLLSYHGWLLE---PHGAMSSPTKTWLALVRIFSG-RHPMLFSYQRSLPRQPVPSVQDTVRKY 186
            |:|||.|.||:.|   |...:|.||..|:|:||:.|. ..|.|:|:|.||||.|:|||:||:.:|
  Fly   122 LKLLLMYKGWMYESRAPGSRVSLPTMLWVAVVRVLSSWNKPGLYSFQGSLPRLPLPSVKDTMTRY 186

Human   187 LESVRPILSDEDFDWTAVLAQEFLRLQASLLQWYLRLKSWWASNYVSDWWEEFVYLRSRNPLMVN 251
            |.||||:|.||::.....||:||.:.....|||||.|||||::|||||||||:||||.|:||.||
  Fly   187 LRSVRPLLDDENYTRMERLAKEFEQTIGKKLQWYLILKSWWSTNYVSDWWEEYVYLRGRSPLCVN 251

Human   252 SNYY-----------MMAARAGNAVHALLLYRHRLNRQEIPPVRGPQWVRDGGVVLWPLGHVGPG 305
            ||:|           ..||||.|.:..||.:|..:..||:.|:
  Fly   252 SNFYGTDAIFMNLTDKQAARAANVISLLLNFRRLIEHQELQPI---------------------- 294

Human   306 RQLTAHGFLQTLLMGMRPLCSAQYEKIFNTTRIPGVQKDYIRHLHDSQHVAVFHRGRFFRMGTHS 370
                       ::.||.||||.|||:.|||.|:||::.|.|.|..||.|:.|.|:|.:::|..:.
  Fly   295 -----------MVQGMIPLCSWQYERTFNTARVPGLETDRIIHYRDSNHIVVLHKGCYYKMLIYY 348

Human   371 RNSLLSPRALEQQFQRILDDPSPACPHEEHLAALTAAPRGTWAQVR----------TSLKTQAAE 425
            :..:|.|..|:.|.:.||...:.....|||||||||..|..||:.|          |||:|
  Fly   349 KGRILRPCELQVQIEEILKGKATPVEGEEHLAALTAWNRSKWAEARNTFFSWGVNQTSLRT---- 409

Human   426 ALEAVEGAAFFVSLDAEPAGLTREDPAASLDAYAHALLAGRGHDRWFDKSFTLIVFSNGKLGLSV 490
                :|.|||.:|||.||.......|.. ||.:...||.|.|::|||||.||:.|.:||::|.:.
  Fly   410 ----IESAAFVLSLDDEPFEFDLARPEL-LDNFGKKLLHGNGYNRWFDKCFTVCVGTNGRVGFNA 469

Human   491 EHSWADCPISGHMWEFTLATECFQLGYSTDGHCKGHPDPTLPQPQRLQWDLPDQIHSSISLALRG 555
            ||:|:|..|:.||||..:..:....||...|:.||.|....|.|.||.|||...:.......:..
  Fly   470 EHTWSDAAIASHMWENLIVDDLVSDGYDETGNTKGTPAFQPPTPTRLTWDLKPCLAQIEEATIDV 534

Human   556 AKILSENVDCHVVPFSLFGKSFIRRCHLSSDSFIQIALQLAHFRDRGQFCLTYESAMTRLFLEGR 620
            .|:::| |:..::....:||.|:::|.:|.|::||:|||||::||.|:|.||||::|||||.|||
  Fly   535 TKLINE-VNLRILVHQDYGKGFMKKCRISPDAYIQMALQLAYYRDAGRFSLTYEASMTRLFREGR 598

Human   621 TETVRSCTREACNFVRAMEDKEKTDPQCLALFRVAVDKHQALLKAAMSGQGVDRHLFALYIVSRF 685
            |||||.||.|:..:|:||::...|:.:.:.:.:.|.|:||...:.||.|:|:|||||.||:||::
  Fly   599 TETVRPCTIESSAWVKAMQNPNTTNDERVKMMQAACDRHQLGYQDAMCGRGIDRHLFCLYVVSKY 663

Human   686 LHLQSPFLTQVHSEQWQLSTSQIPVQQMHLFDVHNYPDYVSSGGGFGPADDHGYGVSYIFMGDGM 750
            |.:.||||.:|.||.|:|||||.|..|....|:..:|:.:|:||||||..|.|||||||..|:.:
  Fly   664 LEVDSPFLNEVLSEPWRLSTSQTPHGQTPKMDLKKHPNCISAGGGFGPVADDGYGVSYIIAGENL 728

Human   751 ITFHISSKKSSTKTDSHRLGQHIEDALLDVASLFQAGQHFK 791
            |.||||:|.:..:||.||..|:|..||.|:.|:|:  ||.|
  Fly   729 IFFHISAKTTCQQTDVHRFAQNISQALSDIRSMFE--QHMK 767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CPT1C	NP_001365411.1	CPT_N	1..47	CDD:465132	20/45 (44%)
		Carn_acyltransf	174..775	CDD:459926	265/621 (43%)
whd	NP_001163111.1	CPT_N	1..47	CDD:465132	20/45 (44%)
		Carn_acyltransf	174..753	CDD:459926	265/621 (43%)