Protein Alignment CNGA3 and sei

DIOPT Version :10

• Sequence 1: XP_011508856.1
• Gene: CNGA3 / 1261
• HGNCID: 2150
• Length: 749
• Species: Homo sapiens
• Sequence 2: NP_476713.1
• Gene: sei / 37843
• FlyBaseID: FBgn0003353
• Length: 855
• Species: Drosophila melanogaster
• Alignment Length: 651
• Identity: 159/651 - (24%)
• Similarity: 278/651 - (42%)
• Gaps: 125/651 - (19%)

Human   152 SFPDRFRGAELKEVSSQESNAQAN-----------VGS------QEPADRGRSAWPLAKCNTNTS 199
            |:...|:..:..:......|...|           :||      |:|.|          ..|:..
  Fly   240 SYECMFKNLKYNQAEKPTDNVMGNSYDDMLDKEALLGSKSEPKGQDPND----------MITSLG 294

Human   200 NNTEEEKKTKKKDAIVVDPSSNLYYRWLTAIALP--VFYNWYLLICRACFDELQSEYLMLWL--- 259
            .|...::|.:          :|.|::|......|  ..::|.:||. ..:..:.:.|:..:|
  Fly   295 GNILLDQKLQ----------NNYYHKWTLLHYSPFKAVWDWIILIL-VMYTAIFTPYVAAFLLGE 348

Human   260 -----------------VLDYSADVLYVLDVLVRARTGFL-EQGLMVSDTNRLWQHYKTTTQFKL 306
                             ::|...||.:::|:::..||.|: .|..:||...|:..|| .:..|.:
  Fly   349 QDYQRRNSKYINSDPIVIIDLIVDVTFIVDIIINFRTTFVNSQDEVVSHPGRIAVHY-LSGWFLI 412

Human   307 DVLSLVPTDLAYLKVGTNYPE-------VRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLY 364
            |:::.||.||  |.||::..|       ::..|||:..|:....||..         ..|..||.
  Fly   413 DLVAAVPFDL--LLVGSDTDETTTLIGLLKTARLLRLVRVARKIDRYS---------EYGAAVLI 466

Human   365 IL-----IIIHWNACIYFAI--------SKFIGFGTDSWVYPNISIPEHGR------LSRKYIYS 410
            :|     :|.||.|||::||        ||.||: .:|..| :|..|....      :..:||.:
  Fly   467 LLMATFILIAHWLACIWYAIGNAEKSIASKNIGW-LNSLAY-DIQEPYFDNRTGGPSIKSRYITA 529

Human   411 LYWSTLTLTTIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDS 474
            ||::..:||::| ....|..|.|..|.:...|||.|::|:|.|||.::|..:.:..|.:..::..
  Fly   530 LYFTFTSLTSVGFGNVAPNTDAEKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQMLR 594

Human   475 IKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQ 539
            ::::::|.::...|..|:..:|.:.|.....:|...:||..|:.|:|:|.::::...|.....|.
  Fly   595 VREFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNSLLKGFPECLQADICLHLNRKLLTTCAAFS 659

Human   540 DCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGE 604
            :...|.|....||.:.|...|||.:..:||:...:|.|..|.:.:.....:   |||.....|||
  Fly   660 EASPGCLRAFSLKFKTTHAPPGDILVHRGDVLTSLYFIARGSIEIQRAGNI---VVLGKNDIFGE 721

Human   605 ISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDE 669
            ...:.....||    ...:|::.|.|:..|.:|||::.|..|||   .||.....:::..|:.|:
  Fly   722 NPCIYPTVGKS----NGVVRALTYCDIHKLHRDDLLDVLDSYPE---FLESFVSNLVITYNMRDD 779

Human   670 ELARAGADPKD--LEEK-VEQLGSSLDTLQTRFARLLAEYNATQMKMKQRLSQLESQVKGGGDKP 731
            |  .:|.|.|.  |..| .:::.||.|....|...|  .|.      ||.::....:||....:.
  Fly   780 E--HSGVDIKHRYLRAKSSDKMRSSPDIPSIRIVGL--RYK------KQNVNTSVHKVKNDNSRD 834

Human   732 L 732
            |
  Fly   835 L 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CNGA3	XP_011508856.1	Ion_trans	223..465	CDD:459842	78/291 (27%)
		CAP_ED	537..653	CDD:237999	33/115 (29%)
		CLZ	653..722	CDD:465160	18/71 (25%)
sei	NP_476713.1	Ion_trans	322..583	CDD:459842	75/275 (27%)
		CAP_ED	657..767	CDD:237999	35/119 (29%)