Protein Alignment CNGA3 and CG42260

DIOPT Version :10

• Sequence 1: XP_011508856.1
• Gene: CNGA3 / 1261
• HGNCID: 2150
• Length: 749
• Species: Homo sapiens
• Sequence 2: NP_001356969.1
• Gene: CG42260 / 37614
• FlyBaseID: FBgn0259145
• Length: 1269
• Species: Drosophila melanogaster
• Alignment Length: 731
• Identity: 275/731 - (37%)
• Similarity: 401/731 - (54%)
• Gaps: 105/731 - (14%)

Human    77 QKKSQPEKVVRAASRGRPLIG-W---TQWCAED----GGDESEMALAGS--------------PG 119
            |:.....::..|||..:||:| |   |...::|    ||..:.:|:.|.              |.
  Fly   406 QRNKSRGRLKTAASGDQPLLGTWNRSTGRGSQDNTLAGGGATSLAMGGHNQYGGNYCNGTDRYPR 470

Human   120 CSSGPQGRLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESN--------AQANV 176
            ..|..||..:         ||:..||..|             |:..:|..|:        :|...
  Fly   471 SRSQQQGHHN---------AAQQAHHPYQ-------------LQHSASTVSHHPHAHGPPSQGGP 513

Human   177 GSQEPADRG--------------------RSAWPLAKCNTNTSNNTEEEKKTKKKDAIVVDPSSN 221
            |...|...|                    ....|..:....|::.........:|...|.||:..
  Fly   514 GGPGPPHGGHPHHPHHGGAGSGGGSGPGSHGGQPHHQKPRRTASQRIRAATAARKLHFVFDPAGR 578

Human   222 LYYRWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGL 286
            |.|.|...:::...||::::|.|..|.|:....:.:|..|||.:|.||::|:|...|||:||.|:
  Fly   579 LCYYWSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDILFHFRTGYLEDGV 643

Human   287 MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTN 351
            :.:|..:|..||..:|.|.:|.|.|:|.|..||.:|.| ..:|..||:|..|.:.|.||||..||
  Fly   644 LQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYLSIGFN-SILRSFRLVKIYRFWAFMDRTERHTN 707

Human   352 YPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTL 416
            |||:||...|:.|:|:|.|||.|:|..|.|..|||:.:|||.:   .|...:.::|:.|.||.||
  Fly   708 YPNLFRSTALIHYLLVIFHWNGCLYHIIHKNNGFGSRNWVYHD---SESADVVKQYLQSYYWCTL 769

Human   417 TLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQF 481
            .|||||:.|.|....||:||::..|.|:::|||::|:|.:::::::|:|.|||||:|.:|.||:.
  Fly   770 ALTTIGDLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRM 834

Human   482 RKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLL 546
            |:|...|:.:||:||||||..:|..||:..:..|||||||||||||||||||:|.|||:.|||.|
  Fly   835 RRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFL 899

Human   547 VELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIK 611
            .||||:|||.:||||||||:||::||||||:|.|:|.||||:|.|....|..|||||||||||:
  Fly   900 CELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNM- 963

Human   612 GSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALE-------EKGRQILMKD----N 665
             ..:||||||::||:||||||.|||.|:.:.|.|||.|:..||       ||.::..::.    |
  Fly   964 -GTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLESIAVKRLEKYKKAPLEKVKYFN 1027

Human   666 LIDEELARAGADPKDLEE----KVEQL-------GSSLDTLQTRFARLLAEYNATQMK-MKQRLS 718
            ::  .:.|..:.|..:|.    .:|::       |:|  :|......|..::.|:|.: .:|..:
  Fly  1028 VV--AMGRCQSTPGLVESCGRTSLEEMWLPPATAGAS--SLMHHHQALQQQHQASQQQPHRQEST 1088

Human   719 QLESQVKGGGDKPLAD 734
            |..||..|...:..||
  Fly  1089 QTSSQTHGYSPRSYAD 1104

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CNGA3	XP_011508856.1	Ion_trans	223..465	CDD:459842	98/241 (41%)
		CAP_ED	537..653	CDD:237999	74/115 (64%)
		CLZ	653..722	CDD:465160	17/91 (19%)
CG42260	NP_001356969.1	Ion_trans	581..820	CDD:459842	99/242 (41%)
		CAP_ED	890..1004	CDD:237999	74/115 (64%)