Protein Alignment CNGA3 and CngB

DIOPT Version :10

• Sequence 1: XP_011508856.1
• Gene: CNGA3 / 1261
• HGNCID: 2150
• Length: 749
• Species: Homo sapiens
• Sequence 2: NP_611607.2
• Gene: CngB / 37479
• FlyBaseID: FBgn0266346
• Length: 1040
• Species: Drosophila melanogaster
• Alignment Length: 717
• Identity: 228/717 - (31%)
• Similarity: 372/717 - (51%)
• Gaps: 87/717 - (12%)

Human    76 IQKKSQPEKVVRAASRGRPLIGWTQWCAEDGGDESEM---------ALAGSPGCSSGPQGRLSRL 131
            :|.:.:.|:..|.     |.|..::..|.|..| :||         :.|||.. |.|.|....::
  Fly   315 LQNEDRNERTQRT-----PSINESEIVAVDEPD-TEMNSDVDHRKPSSAGSLD-SQGQQFLRDQV 372

Human   132 IFLLRRWAAR--HVHHQDQGPDSFPDRFRGAELKEVS---------SQESNAQANVGSQEP---- 181
            ..|:||:.||  .|..:.:.|   |.....:.:...|         |.:...:.....|.|
  Fly   373 RHLVRRFTARANKVKSRIELP---PTPSSSSTVSSPSPPPTKSLHPSPQHKVRLVPAGQSPHRGR 434

Human   182 ---ADRGRS-AWPLAKCNTNTSNNTEEEKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLI 242
               ||..|| .|   .|::....|.:|.         .:||...:|..||..::|...||.:::.
  Fly   435 LFEADTPRSNVW---LCSSLCGANNDER---------TLDPQGKIYISWLCVVSLSFLYNAWVIP 487

Human   243 CRACFDELQSEYLMLWLVLDYSADVLYVLDVL-VRARTGFLEQGLMVSDTNRLWQHYKTTTQFKL 306
            .||.|.....|...:||..|:.||::|:|||: .:.|..:|.:|..|.:.|...::|....||||
  Fly   488 LRASFPFQTKENTNIWLACDFCADIIYLLDVVFFKHRVMYLFEGFWVKNKNLTRKNYMRKLQFKL 552

Human   307 DVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHW 371
            |:|:|:|.:|.|.|:||....:||.|..|....:|.|...:...:.|:..|:...:.|:|.:||.
  Fly   553 DLLALLPLELLYFKLGTQAVWLRFPRFFKIQSFWEVFRLLDRVISSPHFVRVAKTLTYMLYMIHI 617

Human   372 NACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFV 436
            .|.:|:|.|.:.|.|.:.||:.....|        |:....::|.|.|:||:.|.|.:..||:|:
  Fly   618 TAALYYAYSDYQGLGQNRWVFSGKGHP--------YVRCFAFATKTATSIGKNPKPERQGEYVFM 674

Human   437 VVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWA 501
            .|.:|:||.:||.::|.:..:||....::.|::...|...:||:...:::::::||..||.:.|.
  Fly   675 TVAWLMGVFVFALLIGQIRDIISTATRNKHEYRQLEDETLEYMRRLNLSQEVQSRVKMWFQFTWE 739

Human   502 NKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICK 566
            .::|:||..:|.:||..||.:|||:||:.||.||::|.|||..||.:||||||...|.|||::|:
  Fly   740 QQRTLDESNILDALPINLKTDIAISVHIQTLSKVQLFADCEEALLRDLVLKLRAVTFLPGDFVCR 804

Human   567 KGDIGKEMYIINEGKLAVVADDGVTQFVV---LSDGSYFGEISILNIKGSKSGNRRTANIRSIGY 628
            ||::|:||||:..|::.|:.  |.:..||   |::||.|||||:|.|.|:   :||||::||.||
  Fly   805 KGEVGREMYIVKLGQVQVMG--GPSSDVVLATLTEGSVFGEISLLGINGA---DRRTADVRSKGY 864

Human   629 SDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELARAGA-----------DPKDLE 682
            |:||.|||.||.|.:..||.|:..|:::.||::.|:...:.|..|..|           :||..|
  Fly   865 SNLFVLSKSDLNEVIAYYPTAQAILKKRARQLMRKNAAREREEERERARSALQADVVIGNPKTPE 929

Human   683 EKVEQLGSSLDTLQTRF-ARLLAEYNATQMKMKQRLSQLESQVKGGGDKPLADGEVPGDATKTED 746
            ...:.|.:.:..|.... |.:|....:.:|:.|::..|:|:.|:       ...||.| |.:|:|
  Fly   930 TAPKLLQTVIQALPFESPAVVLITRGSKRMRRKRQSVQMETIVE-------PKMEVTG-AAETQD 986

Human   747 KQ 748
            ::
  Fly   987 QK 988

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CNGA3	XP_011508856.1	Ion_trans	223..465	CDD:459842	79/242 (33%)
		CAP_ED	537..653	CDD:237999	60/118 (51%)
		CLZ	653..722	CDD:465160	17/80 (21%)
CngB	NP_611607.2	PLN03192	411..>891	CDD:215625	179/504 (36%)
		CAP_ED	775..889	CDD:237999	60/118 (51%)