Protein Alignment CNGA3 and Ih

DIOPT Version :10

• Sequence 1: XP_011508856.1
• Gene: CNGA3 / 1261
• HGNCID: 2150
• Length: 749
• Species: Homo sapiens
• Sequence 2: NP_001033948.1
• Gene: Ih / 36589
• FlyBaseID: FBgn0263397
• Length: 1327
• Species: Drosophila melanogaster
• Alignment Length: 873
• Identity: 204/873 - (23%)
• Similarity: 361/873 - (41%)
• Gaps: 195/873 - (22%)

Human     6 TQYSHPSRTHLKVKTSDRDLNR------------AENGLS-----------RAHSSSEETSSVLQ 47
            |.|:|.|.::...:....:.|.            |..|:|           ..|:||....:.|:
  Fly   510 TDYTHHSSSNGSQQEGSSEANEGHEPVGESTITVASAGVSYPHPYSYPYHYAHHASSATAPANLK 574

Human    48 PGIAMET-----------RGLADSGQGSFTGQGIARF-GRIQKK---SQPEKVVRAASRGRPLIG 97
            ..:.:.:           |..:.|...||..:.|.|. |::..:   ...|:.||.:
  Fly   575 ASLQLHSFGSHHPCPYPARPTSTSCTNSFNRRHIRRHKGKLGDRLLSGDSEESVRCS-------- 631

Human    98 WTQWCAEDGGDESEMALAGSPGCSSGPQGRLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAEL 162
               :|:....:::::.::....|:............|:.......||..|......|.......:
  Fly   632 ---YCSVLNVNDNDLRISFENTCTDSLVTAFDDEALLICDQGTEMVHFDDVSLYGTPKEEPMPNI 693

Human   163 KEVSSQESNAQAN-VGSQ-----EPADRGRSAWPLAKCNTNTSNNTEEEKKTKKKDAIVVDPSSN 221
            ..||.:.|   || :.||     :|.| .|.|   .|...:.....:|..:.|.....|:.|.|:
  Fly   694 PIVSEKVS---ANFLKSQLQSWFQPTD-NRLA---MKLFGSRKALVKERIRQKTSGHWVIHPCSS 751

Human   222 LYYRW-------LTA--IALPV---FYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVL 274
            ..:.|       |.|  |.|||   |:|          |:|.:.    |:..:..:|.::::|::
  Fly   752 FRFYWDLCMLLLLVANLIILPVAISFFN----------DDLSTR----WIAFNCLSDTIFLIDIV 802

Human   275 VRARTGFLEQG---LMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY------------------ 318
            |..|||.::|.   .::.|...:.:|| ..|.|.||::|.:|.|..:
  Fly   803 VNFRTGIMQQDNAEQVILDPKLIAKHY-LRTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQI 866

Human   319 LKVGTNYPEVRFN------RLLKFSRLFEFFDRTE---------------------------TRT 350
            |..|.....:|..      |||:.|||..:..:.|                           |::
  Fly   867 LHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKS 931

Human   351 N----YPNM----FRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKY 407
            |    :.||    .||.||:..:|:|.||:.|:.|.:....||.::|||  :|:..:......:|
  Fly   932 NLILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWV--SINELQESYWLEQY 994

Human   408 IYSLY--WSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQA 470
            .::|:  .|.:.....|..||....:.:| .::..:.|...:|..:|:..::|.::::||.:::.
  Fly   995 SWALFKAMSHMLCIGYGRFPPQSLTDMWL-TMLSMISGATCYALFLGHATNLIQSLDSSRRQYRE 1058

Human   471 KIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTL-KK 534
            |:..:::||.:||:.:|:..|:..:|::.:.. |..||:.:|..|.:||:.:: ||.:..:| ..
  Fly  1059 KVKQVEEYMAYRKLPRDMRQRITEYFEHRYQG-KFFDEELILGELSEKLREDV-INYNCRSLVAS 1121

Human   535 VRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDG 599
            |..|.:.::..:.::|.||:..||.|||.|.|:|.||.:||.|.||.:.:|..:|... ..||||
  Fly  1122 VPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVA-TSLSDG 1185

Human   600 SYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKD 664
            ||||||.:|      :..||.|::|:..|.:||.||.|.....|.:||..:|.:|
  Fly  1186 SYFGEICLL------TNARRVASVRAETYCNLFSLSVDHFNCVLDQYPLMRKTME---------- 1234

Human   665 NLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLA----EYNATQMKMKQRL-----SQL 720
            .:..|.|.:.|.:|..:.:|.|||.:......|.....||    :.....|.:|:.|     |.:
  Fly  1235 TVAAERLNKIGKNPNIMHQKDEQLSNPESNTITAVVNALAAEADDCKDDDMDLKENLLHGSESSI 1299

Human   721 ESQV----------KGGGDKPLADGEVP 738
            ...|          :.|..:.|.:|..|
  Fly  1300 AEPVQTIREGLPRPRSGEFRALFEGNTP 1327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CNGA3	XP_011508856.1	Ion_trans	223..465	CDD:459842	70/317 (22%)
		CAP_ED	537..653	CDD:237999	46/115 (40%)
		CLZ	653..722	CDD:465160	16/77 (21%)
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:400630	9/45 (20%)
		PLN03192	741..>1214	CDD:215625	133/499 (27%)