Protein Alignment CNGA3 and eag

DIOPT Version :10

• Sequence 1: XP_011508856.1
• Gene: CNGA3 / 1261
• HGNCID: 2150
• Length: 749
• Species: Homo sapiens
• Sequence 2: NP_001036275.1
• Gene: eag / 32428
• FlyBaseID: FBgn0000535
• Length: 1270
• Species: Drosophila melanogaster
• Alignment Length: 597
• Identity: 154/597 - (25%)
• Similarity: 272/597 - (45%)
• Gaps: 97/597 - (16%)

Human   210 KKDAIVVDPSSNLYY-----RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLY 269
            :::|....|...|:|     .|...|....||...::.....|....||.:.| ||:|...||::
  Fly   218 RQEAPKTPPHILLHYCAFKAIWDWVILCLTFYTAIMVPYNVAFKNKTSEDVSL-LVVDSIVDVIF 281

Human   270 VLDVLVRARTGFL-EQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDL--AYLK----VGTNYPE 327
            .:|:::...|.|: ..|.:|||...:..:| ..:.|.:|:||.:|.|:  |:.:    :|:.:..
  Fly   282 FIDIVLNFHTTFVGPGGEVVSDPKVIRMNY-LKSWFIIDLLSCLPYDVFNAFDRDEDGIGSLFSA 345

Human   328 VRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTD---- 388
            ::..|||:..|:....||   ...|.....|..|..|:| :.||.|||:::|.:     :|
  Fly   346 LKVVRLLRLGRVVRKLDR---YLEYGAAMLILLLCFYML-VAHWLACIWYSIGR-----SDADNG 401

Human   389 -----------------SWVYPNISIPE--HGRLSRK--YIYSLYWSTLTLTTIG------ETPP 426
                             |:::.|.:.||  :|. |||  |:.:||::...:|::|      ||
  Fly   402 IQYSWLWKLANVTQSPYSYIWSNDTGPELVNGP-SRKSMYVTALYFTMTCMTSVGFGNVAAET-- 463

Human   427 PVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETR 491
               |.|.:|.:...::..|::|||.|:|.::|..|.::.|::...:::::::|:..:|.|.|..|
  Fly   464 ---DNEKVFTICMMIIAALLYATIFGHVTTIIQQMTSATAKYHDMLNNVREFMKLHEVPKALSER 525

Human   492 VIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPT 556
            |:.:....||..|.:|.::||...|..:||:|.::::.....:...|:....|.|..|.:....:
  Fly   526 VMDYVVSTWAMTKGLDTEKVLNYCPKDMKADICVHLNRKVFNEHPAFRLASDGCLRALAMHFMMS 590

Human   557 VFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTA 621
            ..:|||.:...|:....:..|..|.|.|:.||.|.  .:|..|..||:   ...|.|..| :..|
  Fly   591 HSAPGDLLYHTGESIDSLCFIVTGSLEVIQDDEVV--AILGKGDVFGD---QFWKDSAVG-QSAA 649

Human   622 NIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELARAGADPKDLEEKVE 686
            |:|::.|.||..:.:|.|:|.|..|.....:.   .|.:::..||....:.|..||.|..:|..|
  Fly   650 NVRALTYCDLHAIKRDKLLEVLDFYSAFANSF---ARNLVLTYNLRHRLIFRKVADVKREKELAE 711

Human   687 ------QLGSSLDTLQTRFARLLAEYNATQMKMKQRLSQLESQVK------GGGDKPLADGEV-- 737
                  ||..:.|.|   ..::.:::        :|..|:::..|      |..|....||||
  Fly   712 RRKNEPQLPQNQDHL---VRKIFSKF--------RRTPQVQAGSKELVGGSGQSDVEKGDGEVER 765

Human   738 ---PGDATKTED 746
               |...|.|||
  Fly   766 TKLPAKLTLTED 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CNGA3	XP_011508856.1	Ion_trans	223..465	CDD:459842	74/284 (26%)
		CAP_ED	537..653	CDD:237999	33/115 (29%)
		CLZ	653..722	CDD:465160	15/74 (20%)
eag	NP_001036275.1	PAS_9	40..155	CDD:463873
		Ion_trans	238..499	CDD:459842	73/277 (26%)
		CAP_ED	571..682	CDD:237999	33/119 (28%)