DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CNGA2 and cnga2

DIOPT Version :9

Sequence 1:	NP_005131.1	Gene:	CNGA2 / 1260	HGNCID:	2149	Length:	664	Species:	Homo sapiens
Sequence 2:	XP_004916824.1	Gene:	cnga2 / 100494874	XenbaseID:	XB-GENE-992758	Length:	675	Species:	Xenopus tropicalis

Alignment Length:	680	Identity:	457/680 - (67%)
Similarity:	542/680 - (79%)	Gaps:	25/680 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     1 MTEKTNGVKSSPANNHNHHAPP--AIKANGKDDHRTSSRPHSAA---DDDTSSELQRLADVD--- 57
            ||.:.|..|||..:..:|   |  |||...:.:..::....|.|   .|||||||||:...|
Frog     1 MTGQINTQKSSTPSPVSH---PRLAIKTPSETELESAENCGSRALSVCDDTSSELQRVISQDNGD 62

Human    58 ----APQQGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKD 118
                :..:||....||||.|.::|:||:::.|:::.||||||:||||||:|....|....:.::|
Frog    63 VVSHSSFRGRGALSRIVRFVVVLRDWAHRSLRDQDQRPDSFLDRFRGPEVQANDKQPAKDEKEQD 127

Human   119 ----GEDKGTKKKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLD 179
                .:.|..:|..||||:||:|.|||.||.||.:||||||.|||.||||.|||..|..:|..||
Frog   128 KVEQDKKKNDRKVCELFVVDPSGKWYYRWLLVITLPVLYNWFLLVVRACFDDLQTSYVALWFTLD 192

Human   180 YVSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPE 244
            |:.||:||||:.||.|||||||||||:|.|.|.:|||.|||||||:.||:||||.||||.||.||
Frog   193 YICDVIYIADIVIRFRTGFLEQGLLVRDPKTLSNNYIRTLQFKLDIISILPTDLGYFAVGIHRPE 257

Human   245 VRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVY 309
            :||||||||.||||.||:|||||:|||||||.|||||||:|||||.|||||.||:||||.|:|||
Frog   258 LRFNRLLHFPRMFECFDQTETRTSYPNIFRIFNLVLYILLIIHWNGCIYYAFSKAIGFGADSWVY 322

Human   310 PNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSM 374
            ||:|||::|||||||:||||||||||||||:||.|:.|.||||||||||:|||||||||||||||
Frog   323 PNLTDPKHGYLAREYVYCLYWSTLTLTTIGDTPQPMTDTEYLFVIFDFLVGVLIFATIVGNVGSM 387

Human   375 ISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAE 439
            ||||||||.|||:||||:|||||||:|||.:|||||.||||||||||||||||:|||||.|||||
Frog   388 ISNMNATRTEFQSKIDAIKHYMQFRRVSKDLEAKVILWFDYLWTNKKTVDEREVLKNLPDKLRAE 452

Human   440 IAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVAD 504
            |||||||.||||||||.:|||||||||||||||||||||||||||||||:|||||||||||||.:
Frog   453 IAINVHLDTLKKVRIFQNCEAGLLVELVLKLRPQVFSPGDYICRKGDIGREMYIIKEGKLAVVGE 517

Human   505 DGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKV 569
            ||:|.||:|::||||||||||||:||||||||||:|||:||||||||||||||||:.|||||||:
Frog   518 DGITHYAVLTSGSCFGEISILNIEGSKMGNRRTASIRSIGYSDLFCLSKDDLMEALVEYPDAKKI 582

Human   570 LEERGREILMKEGLLDENEVATSME-VDVQEKLGQLETNMETLYTRFGRLLAEYTGAQQKLKQRI 633
            |||||||||:|||||||.:...|:: ...:|:|..:|:|::.|:|||.|||.||:.|||.||||:
Frog   583 LEERGREILIKEGLLDETKEKISVKGKSSEERLELVESNLDILHTRFARLLREYSNAQQTLKQRV 647

Human   634 TVLETKMKQNNEDDYLSDGMNSPELAAADE 663
            |:||.|::..:..:..|||..|     |||
Frog   648 TLLELKLRDIHGGEVSSDGQES-----ADE 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNGA2	NP_005131.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49		17/52 (33%)
		Ion_trans	174..382	CDD:278921	164/207 (79%)
		Radical_SAM	415..>468	CDD:302752	47/52 (90%)
		Crp	448..632	CDD:223736	141/184 (77%)
		CAP_ED	454..570	CDD:237999	100/115 (87%)
		CLZ	570..639	CDD:293134	40/69 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	641..664		7/23 (30%)
cnga2	XP_004916824.1	Ion_trans	153..395	CDD:366146	187/241 (78%)
		Radical_SAM	428..>481	CDD:388499	47/52 (90%)
		CAP_ED	467..583	CDD:237999	100/115 (87%)
		CLZ	583..651	CDD:374604	38/67 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	400	1.000	Domainoid score	I5991
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32022
Inparanoid	1	1.050	905	1.000	Inparanoid score	I3681
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48384
OrthoDB	1	1.010	-	-		D106044at7742
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	1	1.000	-	-		oto149132
Panther	1	1.100	-	-	LDO	PTHR45638
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X511
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.080