DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CNGA1 and CngA

DIOPT Version :9

Sequence 1:	XP_005248106.2	Gene:	CNGA1 / 1259	HGNCID:	2148	Length:	765	Species:	Homo sapiens
Sequence 2:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster

Alignment Length:	710	Identity:	316/710 - (44%)
Similarity:	428/710 - (60%)	Gaps:	68/710 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    85 INTQQSFVTMPNVIVPDI--------------EKEIRRMENGAC---SSFSEDDDSASTSEESE- 131
            |..:|:..::|..:..::              .:.|.|...|..   ....||||.....::.|
  Fly    92 ITVEQAATSIPMAVDGEVHHLHYPRRSWQRKYRQGIHRQPGGGAEQDEDEEEDDDDVDEDDDDEF 156

Human   132 -----NENPH---ARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKK 188
                 .:||.   ||....        ..|::.|.|.|.....|.|.....|||.::.|....::
  Fly   157 GASVCEDNPEEAIARADHD--------TQQKQHYQPNASDSSYVENGRKLIQEPSKRSKPSALRR 213

Human   189 S----KSDDKNENKNDP-----EKKKKKKDKEKKKK----EEKSKDKKEEEKKEVVV----IDPS 236
            :    :......|:..|     ||.....:.:|..|    .|.:....|.....|:.    :||:
  Fly   214 TLQALRQRLTKRNRPKPPDWFLEKFSNTTNTDKIGKGCPAMEDAALSSEIRGSSVLCNRLSVDPT 278

Human   237 GNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQ 301
            ..::|.||..::|.|:||...|:.||.|.|:......:|..|||:.|.:||:|..|....|:|:|
  Fly   279 LQSHYRWLAIVSLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFLDQ 343

Human   302 GLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE------------IRLNRLLRFS 354
            ||||::..:|...|.....:.|||||::||||.|.   |..||            :|||||||.:
  Fly   344 GLLVRDAFRLRRHYFHTKGWYLDVLSMLPTDLAYI---WWPPETCSSLYLPCPVIVRLNRLLRIN 405

Human   355 RMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGR 419
            |::|:|.||||.|.|||.|||..:|:.|:::||||||::::||..|||.:|:||| ::|......
  Fly   406 RLWEWFDRTETATGYPNAFRICKVVLAILVLIHWNACMYFAISYEIGFSSDSWVY-NLNGTRNNT 469

Human   420 LARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAE 484
            |.|:|:||.||||||||||||||.|..|.||:|||.|||.||||||||||||||||||||.||.|
  Fly   470 LQRQYIYSFYWSTLTLTTIGETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVE 534

Human   485 FQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTL 549
            ||.|:|.:||||.||.|..::|.|||:||.|.|:....:||:.||..|||||:|||||.||:|||
  Fly   535 FQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTL 599

Human   550 KKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLS 614
            |:||||.|.|.|||..|||||:.||:|||||||:|||:|:||||:|.|||:||.|||:|....|.
  Fly   600 KQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATLG 664

Human   615 DGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILM 679
            .||.|||:|:|.|.|::.|||||||::|:||||||||:|.||.|.|::||:|::.|.::|.|:|.
  Fly   665 AGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLLR 729

Human   680 KDGLLDLNI-ANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTKVE 738
            ||||||..| |::......:|..:.::|.||:.|..|.||:||||.:.|.|:||||.|:|
  Fly   730 KDGLLDEQIFADSQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQAKIKQRLAKLE 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNGA1	XP_005248106.2	None
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	117/223 (52%)
		Ion_trans_2	<477..527	CDD:285168	41/49 (84%)
		Crp	598..>722	CDD:223736	79/123 (64%)
		CAP_ED	604..717	CDD:237999	72/112 (64%)
		CLZ	720..791	CDD:293134	32/70 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145016
Domainoid	1	1.000	269	1.000	Domainoid score	I1853
eggNOG	1	0.900	-	-		E1_KOG0500
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	585	1.000	Inparanoid score	I1006
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48384
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	1	1.000	-	-		otm41599
orthoMCL	1	0.900	-	-		OOG6_100817
Panther	1	1.100	-	-	O	PTHR45638
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X511
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770