DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF816 and LOC108645295

DIOPT Version :9

Sequence 1:	NP_001026835.1	Gene:	ZNF816 / 125893	HGNCID:	26995	Length:	651	Species:	Homo sapiens
Sequence 2:	XP_031757810.1	Gene:	LOC108645295 / 108645295	-ID:	-	Length:	587	Species:	Xenopus tropicalis

Alignment Length:	528	Identity:	139/528 - (26%)
Similarity:	212/528 - (40%)	Gaps:	152/528 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    15 PGMALPQ------------------GRLTFR--DVAIEFSLEEWKCLNPAQRALYRAVMLENYRN 59
            ||.||.:                  |.:..|  ||::.||||||:.|. ..:..||.|:.||.:.
Frog    78 PGSALQKENAKRILELISNIIQLLTGEVAIRCEDVSLYFSLEEWQYLK-GNQTRYREVIKENRQQ 141

Human    60 LEFVDSSLKSMMEFSSTRHSITGEVIH------TGTLQRHKSHHIGDFCFPEM-----KKDIHHF 113
            |..:..   :..:.|:::.::..::.:      ||..:       ||...|::     :...:.|
Frog   142 LRPLGC---AHGDGSASKPAVGADLCNAKEPDKTGAEE-------GDPPNPDIAPTDPQTATNCF 196

Human   114 EFQWQEVERNGHEAPMTKIKKLTGSTDRSDHRHAGNKPIKDQLGLSFHS--------HLPELHMF 170
            ....:|...:..|....||..||.:        .|:.||.   .||.|:        ..|..|
Frog   197 SHGIKEEPTSWEEYSDWKIDSLTDT--------GGSGPIG---SLSAHNGPNGIKKEAAPWEH-- 248

Human   171 QTKGKISNQ-----LDKSIGASSASESQRISCRLKTHISNKYG--------------KNFLHSSF 216
               ||.||:     ||:..|:...:::.|.|  |...:|..||              .::..||.
Frog   249 ---GKCSNRNIKPLLDQIPGSEPLTDNMRSS--LNNSLSAGYGSQRIKEEPDSWEVYSDWTMSSL 308

Human   217 TQ-IQ-EICMREKP--C-----QSNECGKAFNYSSLLRRHHITHSRERE---------------- 256
            |: :| :...|:.|  |     .|...|:..::.| |..:.::...|.|
Frog   309 TEPVQADAAHRKGPSVCSSLSEHSGSNGETASWVS-LSVNSLSGCTEGEPIPQKVGGASDPKCNP 372

Human   257 ---------------------------------------YKCDVCGKIFNQKQYIVYHHRCHTGE 282
                                                   |.|..|||.|..:::...|.|.||.|
Frog   373 TGTPRTAPPIPIIGPSPKQQDGIRILTSTQPGAPKPKVIYTCSACGKPFTSRKHCERHQRVHTRE 437

Human   283 KTYKCNECGKTFTQMSSLVCHRRLHTGEKPYKCNECGKTFSEKSSLRCHRRLHTGEKPYKCNECG 347
            .|:.|.||||.|||.|.|..|.|:|:|:..:.|.||||.|..:|.|..|...||||||:.|.:||
Frog   438 TTFPCAECGKCFTQRSHLTAHSRMHSGDNSFTCAECGKCFLFQSDLNRHVITHTGEKPFSCAQCG 502

Human   348 KTFGRNSALVIHKAIHTGEKPYKCNECGKTFSQKSSLQCHHILHTGEKPYKCEECDNVYIRRSHL 412
            |.||...:|..|..||:|.||:.|.:|||.:..:..|..|.:.|:|:||:.|.:|...:..:..|
Frog   503 KHFGHLYSLKRHLVIHSGNKPFPCPQCGKCYWHQGDLNRHIVTHSGQKPFSCAQCGKCFWVQRDL 567

Human   413 ERHRKIHT 420
            .||.:.||
Frog   568 SRHVRGHT 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF816	NP_001026835.1	KRAB	24..64	CDD:307490	16/41 (39%)
		C2H2 Zn finger	232..251	CDD:275368	3/18 (17%)
		C2H2 Zn finger	259..279	CDD:275368	7/19 (37%)
		COG5048	283..650	CDD:227381	60/138 (43%)
		C2H2 Zn finger	287..307	CDD:275368	12/19 (63%)
		C2H2 Zn finger	315..335	CDD:275368	9/19 (47%)
		C2H2 Zn finger	343..363	CDD:275368	8/19 (42%)
		C2H2 Zn finger	371..391	CDD:275368	6/19 (32%)
		C2H2 Zn finger	399..419	CDD:275368	5/19 (26%)
		C2H2 Zn finger	427..447	CDD:275368
		C2H2 Zn finger	455..475	CDD:275368
		C2H2 Zn finger	483..503	CDD:275368
		C2H2 Zn finger	511..531	CDD:275368
		C2H2 Zn finger	539..559	CDD:275368
		C2H2 Zn finger	567..587	CDD:275368
		C2H2 Zn finger	595..615	CDD:275368
		C2H2 Zn finger	623..643	CDD:275368
LOC108645295	XP_031757810.1	KRAB_A-box	107..145	CDD:143639	16/38 (42%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	426..451	CDD:404364	12/24 (50%)
		zf-C2H2	440..462	CDD:395048	12/21 (57%)
		C2H2 Zn finger	442..462	CDD:275368	12/19 (63%)
		C2H2 Zn finger	470..490	CDD:275368	9/19 (47%)
		zf-H2C2_2	482..507	CDD:404364	13/24 (54%)
		C2H2 Zn finger	498..518	CDD:275368	8/19 (42%)
		zf-H2C2_2	510..535	CDD:404364	11/24 (46%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	538..562	CDD:404364	8/23 (35%)
		C2H2 Zn finger	554..574	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	470	1.000	Inparanoid score	I8087
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960