Protein Alignment CNGB1 and CG42260

DIOPT Version :10

• Sequence 1: NP_001288.3
• Gene: CNGB1 / 1258
• HGNCID: 2151
• Length: 1251
• Species: Homo sapiens
• Sequence 2: NP_001356969.1
• Gene: CG42260 / 37614
• FlyBaseID: FBgn0259145
• Length: 1269
• Species: Drosophila melanogaster
• Alignment Length: 604
• Identity: 205/604 - (33%)
• Similarity: 311/604 - (51%)
• Gaps: 53/604 - (8%)

Human   649 DPLTNLMYVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRL 713
            ||...|.| .|...|.||:.:|.|:|..|:||.......|..|..:|||.|.:|.:|| :|..|.
  Fly   574 DPAGRLCY-YWSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDI-LFHFRT 636

Human   714 QFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSR 778
            .::..|.:.||...:|.:|:.|..|.:|.|.|||||||||.:|.|.:||..|.:|...|:.|..|
  Fly   637 GYLEDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYLSIGFNSILRSFRLVKIYRFWAFMDR 701

Human   779 LESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYD-----GVGNSYIRCYYF 838
            .|...:...::|......|||...|.|.|||:......|.||.:|||.     .|...|::.||:
  Fly   702 TERHTNYPNLFRSTALIHYLLVIFHWNGCLYHIIHKNNGFGSRNWVYHDSESADVVKQYLQSYYW 766

Human   839 AVKTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKY 903
            ....|.|||.||.|::..|.||.:|....|:..|:.::|.:.::|.:.:|.:..:::.:|....|
  Fly   767 CTLALTTIGDLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTY 831

Human   904 MNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDR 968
            |...::|..:|.:|..|::|.|.:|...||...:..||||::.::||:|:.:.:.:|.:||..:.
  Fly   832 MRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEA 896

Human   969 QMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISL 1033
            ..:.:::.|||.|::.|.||:|:|||:|:||||:..|::||: ..:||:|:.:|||||.|||||:
  Fly   897 GFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVV-ADNGKTVMASLKAGSYFGEISI 960

Human  1034 LAVG-GGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRMLRSNNKPKEEKSVL 1097
            |.:| .||||||:|.:.|:::||:|.|||:.::|..||.::..|...|.:.|....|...||
  Fly   961 LNMGTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLESIAVKRLEKYKKAPLEK--- 1022

Human  1098 ILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHL-RARLKELAALEAAA-------KQQELVEQ 1154
                    .|.||..     .||...:..|.:... |..|:|:....|.|       ..|.|.:|
  Fly  1023 --------VKYFNVV-----AMGRCQSTPGLVESCGRTSLEEMWLPPATAGASSLMHHHQALQQQ 1074

Human  1155 AKSSQDVKGEEGSAAPDQHTH---PKEAATDPPAPRTPPEPPGSPPSSPPPASLGRPEGEEEGPA 1216
            .::||.....:.|......||   |:..| |..|..|     .||.|..|.|     .|.||.|.
  Fly  1075 HQASQQQPHRQESTQTSSQTHGYSPRSYA-DRLARAT-----DSPRSVSPSA-----HGSEERPR 1128

Human  1217 E--PEEHSVRICMSPGPEP 1233
            .  ...||:|    |..:|
  Fly  1129 SRTTSHHSIR----PQSQP 1143

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CNGB1	NP_001288.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..75
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..151
		PRK10263	<167..>311	CDD:236669
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	172..252
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	314..561
		Calmodulin-binding CaM1. /evidence=ECO:0000250|UniProtKB:Q28181	557..567
		IQ-like	568..578
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	585..619
		PLN03192	648..>1034	CDD:215625	142/389 (37%)
		Ion conduction pathway. /evidence=ECO:0000305|PubMed:34699778	786..885		34/103 (33%)
		C-linker. /evidence=ECO:0000305|PubMed:34699778	888..964		21/75 (28%)
		CAP_ED	962..1071	CDD:237999	52/109 (48%)
		Cyclic nucleotide-binding domain. /evidence=ECO:0000305|PubMed:34699778, ECO:0007744|PDB:7RHI	968..1084		53/116 (46%)
		Calmodulin-binding CaM2. /evidence=ECO:0000250|UniProtKB:Q28181	1148..1154		2/5 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1151..1251		26/88 (30%)
CG42260	NP_001356969.1	Ion_trans	581..820	CDD:459842	85/240 (35%)
		CAP_ED	890..1004	CDD:237999	53/114 (46%)