Protein Alignment Cdk6 and Cdk4

DIOPT Version :9

• Sequence 1: NP_034003.1
• Gene: Cdk6 / 12571
• MGIID: 1277162
• Length: 326
• Species: Mus musculus
• Sequence 2: NP_001286493.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Alignment Length: 308
• Identity: 137/308 - (44%)
• Similarity: 206/308 - (66%)
• Gaps: 8/308 - (2%)

Mouse     1 MEKDSLSRADQ-------QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTSEEGMPLST 58
            :::..:|:|.:       .|:.:..|||||||.|::|||:.. |..||||:||:..:|.|:|:||
  Fly     7 LKRQKMSQAKKFGDGDPFNYQELNIIGEGAYGTVYRARDVIT-GNIVALKKVRISLNENGVPMST 70

Mouse    59 IREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIK 123
            :||:::|:.|....|.|:|:|::||.....|.:..:.||||||:|||:..:|::|:.|:...||:
  Fly    71 LREISLLKQLNASNHANIVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQ 135

Mouse   124 DMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188
            .:..:||.|:|||||||::||||||||:||:|.|.:|:||||||:.|..:|.|||||||||||||
  Fly   136 RLSRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMKLTSVVVTLWYRAP 200

Mouse   189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDIIGLPGEEDWPRDVALPRQA 253
            ||||...|.:.||:||..||..|||.|:.||.|:|:.:||.:|.::.|.|.|:.||:.:::..:.
  Fly   201 EVLLAQPYNSTVDIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVALEH 265

Mouse   254 FHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYGALNHPYFQ 301
            |..:..:..:.|...:.:...|||.|.|:::...|.||...|.|.|||
  Fly   266 FPQRHPKRPKDFCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYFQ 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk6	NP_034003.1	STKc_CDK6	11..300	CDD:270846	132/295 (45%)
Cdk4	NP_001286493.1	STKc_CDK4_6_like	26..312	CDD:270831	132/286 (46%)
		S_TKc	26..312	CDD:214567	132/286 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	279	1.000	Domainoid score	I1684
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H963
Inparanoid	1	1.050	280	1.000	Inparanoid score	I2886
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004605
OrthoInspector	1	1.000	-	-		otm43552
orthoMCL	1	0.900	-	-		OOG6_108285
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2222
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.820