Protein Alignment Cdk2 and Cdk4

DIOPT Version :10

• Sequence 1: NP_904326.1
• Gene: Cdk2 / 12566
• MGIID: 104772
• Length: 346
• Species: Mus musculus
• Sequence 2: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Alignment Length: 346
• Identity: 144/346 - (41%)
• Similarity: 188/346 - (54%)
• Gaps: 70/346 - (20%)

Mouse     3 NFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL---NHPNIV 64
            |:|::..||||.||.||:|::.:||.:|||||:|:.....|||.:.:|||||||:|   ||.|||
  Fly    25 NYQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQLNASNHANIV 89

Mouse    65 KLLDV---IHTENKL--YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124
            ||.:|   :..:.:|  .||||.:.|||...:|....:|:..|.|:....:||.|:.|.||||::
  Fly    90 KLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELLTGVDFLHSHRII 154

Mouse   125 HRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSL 189
            ||||||||||::::|.:|:||||||:.:|..:: .|..||||||||||:||...|.|| |||||.
  Fly   155 HRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMK-LTSVVVTLWYRAPEVLLAQPYNST-VDIWSA 217

Mouse   190 GCIFAEMHLVCTQHHAKCCGEHRRNGRHSLCPLCSYLEVAASQGGGMTAVSAPHPVTRRALFPGD 254
            .||..||                                                ..|||||||.
  Fly   218 ACIIFEM------------------------------------------------FNRRALFPGT 234

Mouse   255 SEIDQLFRIFRTLGTPDEVVWPGVTSM-----PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQM 314
            ||.:||.|||...|.|.|..||...|:     |...|..||    ||   .|.|.:....||::|
  Fly   235 SEKNQLDRIFELTGRPTEQQWPQTISVALEHFPQRHPKRPK----DF---CPHLCKYADDLLNKM 292

Mouse   315 LHYDPNKRISAKAALAHPFFQ 335
            |.||.:.|.||.|.|.|.:||
  Fly   293 LSYDLHLRPSALACLEHDYFQ 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk2	NP_904326.1	STKc_CDK2_3	3..334	CDD:270844	142/343 (41%)
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	141/342 (41%)