DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdh9 and CadN

DIOPT Version :9

Sequence 1:	XP_011243639.1	Gene:	Cdh9 / 12565	MGIID:	107433	Length:	867	Species:	Mus musculus
Sequence 2:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	157/563 - (27%)
Similarity:	271/563 - (48%)	Gaps:	87/563 - (15%)

- Green bases have known domain annotations that are detailed below.

Mouse   157 TDQDKG-DGNLKYILTGDG------AGNLFVIDENTGDIHAAKRLDREEKSLYILRAKAIDRKTG 214
            ||.||. ..|:.|.|||.|      |.:.|.|:..||:|...|.|||             |:..|
  Fly  1545 TDGDKDRPQNIVYFLTGQGIDPDNPANSKFDINRTTGEIFVLKPLDR-------------DQPNG 1596

Mouse   215 RQVEPESEFI------------------IKIHDINDNEPKFTKDLYTASVPEMSGVGTSVIQVTA 261
            |   |:..|.                  :.:.|||||.|.|.:.:|..:|.|....|..|:.:||
  Fly  1597 R---PQWRFTVFAQDEGGEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVVMTMTA 1658

Mouse   262 TDADDANYGNSAKVVYSILQ-------GQPYFSVDPESGIIKTALPDMSRENKEQYQVVIQAKDM 319
            .|.||.|.|::|::||||.:       |.|.|.::|::|:||||:..:.||....|.:.:.|.|
  Fly  1659 VDYDDPNEGSNARLVYSIEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQVVAMD- 1722

Mouse   320 GGQMGGLSGTTTVNITLTDVNNNPPRFPQSTYQFNSLESAPLGTHLGR-----IKANDPDMGENA 379
               .|||.||.|.:|.:.|:|:.||:|.:..: |..::... ||.|..     :..:|.|  |..
  Fly  1723 ---GGGLKGTGTASIRVKDINDMPPQFTKDEW-FTEVDETD-GTALPEMPILTVTVHDED--ETN 1780

Mouse   380 ELEYSIAE--GEGSDMFDVITDKDTQEGIITVKQNLDFEKKM-----LYTLRVDASNTHPDPRFL 437
            :.:|.:.:  |.|:|.|.::.:.| ..|.:.:.|.||:|.::     .:.::|:......|....
  Fly  1781 KFQYKVIDNSGYGADKFTMVRNND-GTGSLKIVQPLDYEDQLQSNGFRFRIQVNDKGEDNDNDKY 1844

Mouse   438 HLGPFKDSAMVKISVEDV-DEPPVFSKLSYLMEVDEDVKEGSIIGQVTAYDPD-AMNNIIKYSVD 500
            |:.    .:.|.:.:.|: |..|.|.:.:..:.|.||.|.|:.:.:..|.||| ...:.:.||:|
  Fly  1845 HVA----YSWVVVKLRDINDNKPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSID 1905

Mouse   501 RHTDMDRVFSIHSENGSIFTLKPLDRESSPWHNITITATEINNPKQSSQIPVFIRILDINDHAPE 565
            |.:|..|.|:| ::|||:...:.||||..|.|.:.|.|.:..:|.:::...:.:.:.||||:||:
  Fly  1906 RSSDRQRQFAI-NQNGSVTIQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPK 1969

Mouse   566 FATYYETFVCENAKSGQLIQTISVMDKD-----DPPRGHKFFFEPVPEFPLNPNFTIVDNKDNTA 625
            |...|...:.|:....::::.::..|.|     .||  .:|..:|..:..:..:|.:..::....
  Fly  1970 FLKDYRPVLPEHVPPRKVVEILATDDDDRSKSNGPP--FQFRLDPSADDIIRASFKVEQDQKGAN 2032

Mouse   626 G----IVTRKDGYSRNKMNTYLLPVLIFDNDYPIQSSTGTLTI 664
            |    :::....:.|.:...|::|::|.|:..|..:.|.|||:
  Fly  2033 GDGMAVISSLRSFDREQQKEYMIPIVIKDHGSPAMTGTSTLTV 2075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdh9	XP_011243639.1	Cadherin_repeat	150..233	CDD:206637	28/100 (28%)
		Cadherin_repeat	242..342	CDD:206637	40/106 (38%)
		Cadherin_repeat	350..457	CDD:206637	23/119 (19%)
		Cadherin_repeat	465..562	CDD:206637	32/97 (33%)
		Cadherin_repeat	570..667	CDD:206637	20/104 (19%)
		Cadherin_C	715..861	CDD:366437
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637	28/100 (28%)
		Cadherin_repeat	1638..1741	CDD:206637	39/106 (37%)
		Cadherin_repeat	1762..1861	CDD:206637	20/105 (19%)
		Cadherin_repeat	1871..1966	CDD:206637	32/95 (34%)
		Cadherin_repeat	1974..2083	CDD:206637	20/104 (19%)
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5176
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910