DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdh8 and CadN

DIOPT Version :9

Sequence 1:	NP_031693.2	Gene:	Cdh8 / 12564	MGIID:	107434	Length:	799	Species:	Mus musculus
Sequence 2:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster

Alignment Length:	573	Identity:	176/573 - (30%)
Similarity:	294/573 - (51%)	Gaps:	66/573 - (11%)

- Green bases have known domain annotations that are detailed below.

Mouse    94 KKIKYILSGDG------AGTIFQINDITGDIHAIKRLDREE---KAEYTLTAQAVDFETNKPLEP 149
            :.|.|.|:|.|      |.:.|.||..||:|..:|.|||::   :.::..|..|.| |..:.|..
  Fly  1553 QNIVYFLTGQGIDPDNPANSKFDINRTTGEIFVLKPLDRDQPNGRPQWRFTVFAQD-EGGEGLVG 1616

Mouse   150 PSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILE--- 211
            .::..:.::|||||||.|..|.|...|.|....|..|..:||.|.|||..|::|:|||||.:
  Fly  1617 YADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVVMTMTAVDYDDPNEGSNARLVYSIEKNVI 1681

Mouse   212 ----GQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDN 272
                |.|.|.|||:|.:||||:..:|||...:|.:.:.|.|    .|||.||.|.::.:.|:||.
  Fly  1682 EEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQVVAMD----GGGLKGTGTASIRVKDINDM 1742

Mouse   273 PPKFAQSLYHFSVPEDVVLGTAIGR-----VKANDQDIGENAQSSYDIIDGDGTALFEITSDAQA 332
            ||:|.:..:...|  |...|||:..     |..:|:|  |..:..|.:||..|....:.|. .:.
  Fly  1743 PPQFTKDEWFTEV--DETDGTALPEMPILTVTVHDED--ETNKFQYKVIDNSGYGADKFTM-VRN 1802

Mouse   333 QDGV--IRLRKPLDFETKKSYTLKVEAANIHIDPRFSSRGPFKDT-------ATVKIVVEDA-DE 387
            .||.  :::.:|||:|.      ::::.......:.:.:|...|.       :.|.:.:.|. |.
  Fly  1803 NDGTGSLKIVQPLDYED------QLQSNGFRFRIQVNDKGEDNDNDKYHVAYSWVVVKLRDINDN 1861

Mouse   388 PPVFSSPTYLLEVHENAALNSVIGQVTARDPDI-TSSPIRFSIDRHTDLERQFNINADDGKITLA 451
            .|.|......:.|.|:..:.:.:.:..|.|||. ..|.:.:||||.:|.:|||.|| .:|.:|:.
  Fly  1862 KPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQFAIN-QNGSVTIQ 1925

Mouse   452 TPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQT 516
            ..||||:...|.:.|:|.:..:..:.:...:.:.|.|:|||||:|..:|...|.|:..|.:|::.
  Fly  1926 RSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKDYRPVLPEHVPPRKVVEI 1990

Mouse   517 VSAMDKDDPK-NGHFFLYSLLP--EMVNNPNFTIKKNE----DNSLSILAKHNGFNRQKQEVYLL 574
            ::..|.|..| ||..|.:.|.|  :.:...:|.:::::    .:.:::::....|:|::|:.|::
  Fly  1991 LATDDDDRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISSLRSFDREQQKEYMI 2055

Mouse   575 PIVISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYV---------LPIG 618
            ||||.|.|:|.::.|||||: :.|..||..:|..:.:.:|         .|||
  Fly  2056 PIVIKDHGSPAMTGTSTLTV-IIGDVNDNKMQPGSKDIFVYNYQGQSPDTPIG 2107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdh8	NP_031693.2	CA	87..165	CDD:214520	26/79 (33%)
		Cadherin_repeat	171..272	CDD:206637	43/107 (40%)
		Cadherin_repeat	281..387	CDD:206637	24/120 (20%)
		Cadherin_repeat	395..492	CDD:206637	29/97 (30%)
		Cadherin_repeat	499..602	CDD:206637	31/109 (28%)
		Cadherin_C	645..790	CDD:366437
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637	24/77 (31%)
		Cadherin_repeat	1638..1741	CDD:206637	42/106 (40%)
		Cadherin_repeat	1762..1861	CDD:206637	20/107 (19%)
		Cadherin_repeat	1871..1966	CDD:206637	29/95 (31%)
		Cadherin_repeat	1974..2083	CDD:206637	32/109 (29%)
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5176
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910