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Protein Alignment Cdh5 and CadN2

DIOPT Version :9

Sequence 1:	NP_033998.2	Gene:	Cdh5 / 12562	MGIID:	105057	Length:	784	Species:	Mus musculus
Sequence 2:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster

Alignment Length:	838	Identity:	214/838 - (25%)
Similarity:	342/838 - (40%)	Gaps:	208/838 - (24%)

- Green bases have known domain annotations that are detailed below.

Mouse    32 DTPNMLPAHHRQKRDWIWNQMHIDEEKNESLPHYVGKIKS---NVNRQ-NAKYVLQGEF------ 86
            |.|   |...||.     .:..|.||.:.:||..:.::.:   :|:|. |..|.|.|:.
  Fly   131 DNP---PVFDRQT-----YRTQITEEDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNP 187

Mouse    87 AGKIFGVDANTGNVLAYERLDREKVS---EYFLTALIVDKNTNKNLEQPSSFTVKVHDINDNWPV 148
            |...|.::..||::...:.|||::.:   ::..|....|:. .:.|...:...|.:.|||||.|.
  Fly   188 ANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQDEG-GEGLVGYADIQVNLKDINDNAPQ 251

Mouse   149 FSHQVFNASVPEMSAIGTSVIRVTAVDADDPTVAGHATVLYQIVK-------GNEYFSID-NSGL 205
            |...::..:|.|....|:||:.::|||.|||..:.:|.::|.|.|       |...|.|: .:||
  Fly   252 FPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGL 316

Mouse   206 IFTKIKNLDREKQAEYKIVVETQDALGLRGESGTATVMIRLEDINDNFPVFTQSTYTFSVPEDIR 270
            |.|.:..||||:..:|.|.|...|..||:   ||.|..||::|:||..|.||:..:...|.|...
  Fly   317 IKTAVCCLDRERTPDYSIQVVAMDGGGLK---GTGTASIRVKDLNDMPPQFTKDEWVTEVDETNG 378

Mouse   271 VGKP-LGFLTVVDPDEPQNRMTKYSIM--QGEYRDTFTIETDPKRN---EGIIKPTKSLDYEVIQ 329
            ...| ...|||...||.:....:|.::  .|...|.|.:    .||   .|.:|..:.||||...
  Fly   379 TYIPETPILTVTVQDEDETNTFQYKVVPNSGFGADKFAM----VRNGDGTGSLKIIQPLDYEDPL 439

Mouse   330 Q---YTFYIEATDPTIRYEYLSSTSGKNK-----AMVTINVLDV-DEPPVFQRHFYHFKLPENQK 385
            |   :.|.|:..|     :......|.:|     :.|.:.:.|: |..|.|.|......:.|:.|
  Fly   440 QSSGFRFRIQVND-----KGDDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTK 499

Mouse   386 KPLIGTVV----AKDPDKAQRS-IGYSIRKTSDRGQFFRITKQGNIYNEKELDRETYAWYNLTVE 445
               :||::    |.|.|:...| :.|.|.::::|.:.|.|:.:|.:..::.|||||...:::.:.
  Fly   500 ---VGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAISDRGAVSIQRPLDRETQDRHHIQIL 561

Mouse   446 ANELDSRGNPVGKESIVQVYIEVLDENDNPPEFAQPYEPKVCENAAQGKLVVQISATDKD----- 505
            |  :|. |:| .:.:...:.:.|.|.|||.|.|||.|:|.:.||.: ||.:::::|.|.|
  Fly   562 A--IDD-GSP-ARTATATLTVIVKDVNDNAPTFAQDYKPTLPENVS-GKKILEVAAKDPDDRLRG 621

Mouse   506 --------VVPV-NPKFKFALKNEDSNFTLINNHDNTANITVKYGQFNREHAKFHYLPVLISDNG 561
                    :.|: :.:.|...|.|   :....:::|...|......|:||..|.:.:|:.|.|||
  Fly   622 NGGPFTFRLDPLASDEIKAGFKVE---YDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNG 683

Mouse   562 VPSLTGTSTLTVGVCKCNEQGEFTFCEEMAAQAGVSIQALVAIFLCILTITVITLLIILRRRIRK 626
            .|::||||||||.:...|:.         ..|.|
  Fly   684 APAMTGTSTLTVTIGDVNDN---------KMQPG------------------------------- 708

Mouse   627 QAHAHSKSALEIHEQLVTYDEEGGGEM--DTTSYDVSVLNSVRGGSTKPLRSTMDARPAVYTQVQ 689
                 |||.|..:.|..:.|...|...  |...:||.                 |.:  .|.:||
  Fly   709 -----SKSVLVYNYQGQSQDTPIGRVYVNDPDDWDVP-----------------DKK--YYWEVQ 749

Mouse   690 KPPR-----------LAPGLHGGPREMATMIDVKKEEADNDGGGPPYDTLHIYGYEGAESI---- 739
            :..|           :..|...|..::...:               ||..|     |.|.|
  Fly   750 EHQRFKLDTDTGILTMRAGTRRGRYQLRFKV---------------YDREH-----GQEDIPANL 794

Mouse   740 --------AESLSSLSTNSSDSDIDYDFLNDWGP-----------RFK-MLAELYGSD 777
                    ||::....:.......|.||:..|.|           ||: .||||..:|
  Fly   795 SVTVRDITAEAVQQAGSMRLSHITDEDFVRTWNPVKNQVEPSKLERFRNKLAELLYTD 852

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.