DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdh5 and CadN

DIOPT Version :9

Sequence 1:	NP_033998.2	Gene:	Cdh5 / 12562	MGIID:	105057	Length:	784	Species:	Mus musculus
Sequence 2:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster

Alignment Length:	581	Identity:	177/581 - (30%)
Similarity:	279/581 - (48%)	Gaps:	79/581 - (13%)

- Green bases have known domain annotations that are detailed below.

Mouse    54 IDEEKNESLPHYVGKIKS---NVNR-QNAKYVLQGEF------AGKIFGVDANTGNVLAYERLDR 108
            |.||.:.:||..|.::.:   :.:| ||..|.|.|:.      |...|.::..||.:...:.|||
  Fly  1527 ITEEDDRNLPKRVLQVTATDGDKDRPQNIVYFLTGQGIDPDNPANSKFDINRTTGEIFVLKPLDR 1591

Mouse   109 EKVS---EYFLTALIVDKNTNKNLEQPSSFTVKVHDINDNWPVFSHQVFNASVPEMSAIGTSVIR 170
            ::.:   ::..|....|:. .:.|...:...|.:.|||||.|:|...|:..:|.|....|..|:.
  Fly  1592 DQPNGRPQWRFTVFAQDEG-GEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVVMT 1655

Mouse   171 VTAVDADDPTVAGHATVLYQIVK-------GNEYFSID-NSGLIFTKIKNLDREKQAEYKIVVET 227
            :||||.|||....:|.::|.|.|       |:..|.|: ::|:|.|.:..||||:..:|.|.|..
  Fly  1656 MTAVDYDDPNEGSNARLVYSIEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQVVA 1720

Mouse   228 QDALGLRGESGTATVMIRLEDINDNFPVFTQSTYTFSVPEDIRVGKP-LGFLTVVDPDEPQNRMT 291
            .|..||:   ||.|..||::||||..|.||:..:...|.|......| :..|||...||.:....
  Fly  1721 MDGGGLK---GTGTASIRVKDINDMPPQFTKDEWFTEVDETDGTALPEMPILTVTVHDEDETNKF 1782

Mouse   292 KYSIM--QGEYRDTFTIETDPKRNEGI--IKPTKSLDYEVIQQ---YTFYIEATDPTIRYEYLSS 349
            :|.::  .|...|.||:   .:.|:|.  :|..:.||||...|   :.|.|:..|.       ..
  Fly  1783 QYKVIDNSGYGADKFTM---VRNNDGTGSLKIVQPLDYEDQLQSNGFRFRIQVNDK-------GE 1837

Mouse   350 TSGKNK-----AMVTINVLDV-DEPPVFQRHFYHFKLPENQKKPLIGTVVAK----DPDKAQRS- 403
            .:..:|     :.|.:.:.|: |..|.|:|......:.|:.|   :||.:.|    |||:..:|
  Fly  1838 DNDNDKYHVAYSWVVVKLRDINDNKPHFERANVEVSVFEDTK---VGTELEKFKATDPDQGGKSK 1899

Mouse   404 IGYSIRKTSDRGQFFRITKQGNIYNEKELDRETYAWYNLTVEANELDSRGNPVGKESIVQVYIEV 468
            :.|||.::|||.:.|.|.:.|::..::.||||....:.:.:.|  :|....|  |.:...:.:.|
  Fly  1900 VSYSIDRSSDRQRQFAINQNGSVTIQRSLDREVVPRHQVKILA--IDDGSPP--KTATATLTVIV 1960

Mouse   469 LDENDNPPEFAQPYEPKVCENAAQGKLVVQISATDKD--VVPVNPKFKFALKNEDSNFTLIN--- 528
            .|.|||.|:|.:.|.|.:.|:....| ||:|.|||.|  .....|.|:|.|  :.|...:|.
  Fly  1961 QDINDNAPKFLKDYRPVLPEHVPPRK-VVEILATDDDDRSKSNGPPFQFRL--DPSADDIIRASF 2022

Mouse   529 ---------NHDNTANITVKYGQFNREHAKFHYLPVLISDNGVPSLTGTSTLTVGVCKCNE 580
                     |.|..|.|: ....|:||..|.:.:|::|.|:|.|::||||||||.:...|:
  Fly  2023 KVEQDQKGANGDGMAVIS-SLRSFDREQQKEYMIPIVIKDHGSPAMTGTSTLTVIIGDVND 2082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdh5	NP_033998.2	CA	77..147	CDD:214520	20/78 (26%)
		Cadherin_repeat	153..252	CDD:206637	40/106 (38%)
		Cadherin_repeat	260..367	CDD:206637	27/120 (23%)
		Cadherin_repeat	376..474	CDD:206637	29/102 (28%)
		Cadherin_repeat	481..576	CDD:206637	38/108 (35%)
		Required for interaction with PALS1. /evidence=ECO:0000269\|PubMed:27466317	621..660
		Cadherin_C	626..777	CDD:366437
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637	26/103 (25%)
		Cadherin_repeat	1638..1741	CDD:206637	39/105 (37%)
		Cadherin_repeat	1762..1861	CDD:206637	25/108 (23%)
		Cadherin_repeat	1871..1966	CDD:206637	29/101 (29%)
		Cadherin_repeat	1974..2083	CDD:206637	39/113 (35%)
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9567
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000