DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cdh4 and CadN

DIOPT Version :9

Sequence 1:NP_033997.1 Gene:Cdh4 / 12561 MGIID:99218 Length:913 Species:Mus musculus
Sequence 2:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster


Alignment Length:1847 Identity:315/1847 - (17%)
Similarity:465/1847 - (25%) Gaps:1039/1847 - (56%)


- Green bases have known domain annotations that are detailed below.


Mouse    40 YTALISPNVLEGEKLLKVEFSSCVGTKGMQYETNSLDFKVGADGTVFATRELKIPSEQVAFTVTA 104
            :|......|||||.         :|||..|  .|::|    .|||        .|:.||.:.:..
  Fly  1303 FTEREQETVLEGEP---------IGTKVTQ--VNAID----KDGT--------FPNNQVYYYIVD 1344

Mouse   105 RERQSAEQWAAMVRLLVAQ--TSSAHSEHKKG----QTVALD--PSQPPND-------------- 147
            ..|...:::.. :.|...:  |.:.....|||    :..|.|  ||..||.              
  Fly  1345 SPRNEGKEFFE-INLQSGEIFTKTVFDREKKGAYALEVEARDGAPSARPNSNGPNSVTKFIRIGI 1408

Mouse   148 ---------------------------TLL--PWPQHQSSGGLR--------------------- 162
                                       |:|  ....|..|..:|                     
  Fly  1409 ADKNDNPPYFDKSLYEAEVDENEDIQHTVLTVTAKDHDESSRIRYEITSGNIGGAFAVKNMTGAI 1473

Mouse   163 ------------------------RQKRDWVI---------PPI--------NVPENSRGPFPQQ 186
                                    ::....||         ||:        .:.|......|::
  Fly  1474 YVAGALDYETRRRYELRLAASDNLKENYTTVIIHVKDVNDNPPVFERPTYRTQITEEDDRNLPKR 1538

Mouse   187 LVRIRS---DKDNDIPIRYSITGVG--ADQPPMEVFNIDSMSGRMYVTRPMDREE---RASYHLR 243
            ::::.:   |||....|.|.:||.|  .|.|....|:|:..:|.::|.:|:||::   |..:...
  Fly  1539 VLQVTATDGDKDRPQNIVYFLTGQGIDPDNPANSKFDINRTTGEIFVLKPLDRDQPNGRPQWRFT 1603

Mouse   244 AHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADD-STTA 307
            ..|.|..|..:....|:.:.:.|:|||.|.|...||.|:|.|....|..|||:||.|.|| :..:
  Fly  1604 VFAQDEGGEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVVMTMTAVDYDDPNEGS 1668

Mouse   308 NGMVRY----RIVTQTPQSPSQNMFTINSETGDIVTVAAGLDREKVQQYTVIVQATDMEGNLNYG 368
            |..:.|    .::.:...||   :|.|..:||.|.|....||||:...|:  :|...|:|.   |
  Fly  1669 NARLVYSIEKNVIEEETGSP---IFEIEPDTGVIKTAVCCLDRERTPDYS--IQVVAMDGG---G 1725

Mouse   369 LSNTATAIITVTDVNDNPPEFTTSTFAGEV--------PENRIETVVANLTVMDRDQPHSPNWNA 425
            |..|.||.|.|.|:||.||:||...:..||        ||..|.||    ||.|.|:.:    ..
  Fly  1726 LKGTGTASIRVKDINDMPPQFTKDEWFTEVDETDGTALPEMPILTV----TVHDEDETN----KF 1782

Mouse   426 VYRIISGDPSGHFSVRTDPVTNE---GMVTVVKAVDYE---LNRAFMLTVMVSNQAPLASGIQMS 484
            .|::|  |.||:.:.:...|.|.   |.:.:|:.:|||   .:..|...:.|:::.. .:.....
  Fly  1783 QYKVI--DNSGYGADKFTMVRNNDGTGSLKIVQPLDYEDQLQSNGFRFRIQVNDKGE-DNDNDKY 1844

Mouse   485 FQSTAGVTISVTDVNE-APYFPSNHKLIRLEEGVPAGTALTTFSAVDPDRFMQQAVRYS--KLSD 546
            ..:.:.|.:.:.|:|: .|:|...:..:.:.|....||.|..|.|.|||:..:..|.||  :.||
  Fly  1845 HVAYSWVVVKLRDINDNKPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRSSD 1909

Mouse   547 PANWLHINTSNGQITTAAILDRESLYTKNNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPQ 611
            ......|| .||.:|....||||.:..    ::...||.|:|.||.:.|.||.:.:.|||||||:
  Fly  1910 RQRQFAIN-QNGSVTIQRSLDREVVPR----HQVKILAIDDGSPPKTATATLTVIVQDINDNAPK 1969

Mouse   612 LL--------------------------------------------------------------- 613
            .|                                                               
  Fly  1970 FLKDYRPVLPEHVPPRKVVEILATDDDDRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGD 2034

Mouse   614 ----------------------------------------------------------------- 613
                                                                             
  Fly  2035 GMAVISSLRSFDREQQKEYMIPIVIKDHGSPAMTGTSTLTVIIGDVNDNKMQPGSKDIFVYNYQG 2099

Mouse   614 ----------------------------------------------------------------- 613
                                                                             
  Fly  2100 QSPDTPIGRVYVYDLDDWDLPDKKFYWEAMEHPRFKLDEDSGMVTMRAGTREGRYHLRFKVYDRK 2164

Mouse   614 -----------------PKEA-------------------------------------------- 617
                             |.||                                            
  Fly  2165 HTQTDIPANVTVTVREIPHEAVVNSGSVRLSGISDEDFIRVWNYRTQSMSRSKMDRFRDKLADLL 2229

Mouse   618 ----------------------------------------------------------------- 617
                                                                             
  Fly  2230 NTERENVDIFSVQLKRKHPPLTDVRFSAHGSPYYKPVRLNGIVLMHREEIEKDVGINITMVGIDE 2294

Mouse   618 -----QICERPGLNAINI--------------------TAADAD--------------------- 636
                 |:||....|::.|                    |.||..                     
  Fly  2295 CLYENQMCEGSCTNSLEISPLPYMVNANKTALVGVRVDTIADCTCGARNFTKPESCRTTPCHNGG 2359

Mouse   637 --MDPNIGPY------------------------------------------------------- 644
              :|...||:                                                       
  Fly  2360 RCVDTRFGPHCSCPVGYTGPRCQQTTRSFRGNGWAWYPPLEMCDESHLSLEFITRKPDGLIIYNG 2424

Mouse   645 ----------------------------------------------------------------- 644
                                                                             
  Fly  2425 PIVPPERDETLISDFIALELERGYPRLLIDFGSGTLELRVKTKKTLDDGEWHRIDLFWDTESIRM 2489

Mouse   645 ----------------------------------------------------------------- 644
                                                                             
  Fly  2490 VVDFCKSAEIAEMEDGTPPEFDDMSCQARGQIPPFNEYLNVNAPLQVGGLYREQFDQSLYFWHYM 2554

Mouse   645 ------------------VFEL------------------------------------------- 648
                              :::|                                           
  Fly  2555 PTAKGFDGCIRNLVHNSKLYDLAHPGLSRNSVAGCPQTEEVCAQTETTARCWEHGNCVGSLSEAR 2619

Mouse   649 --------------PFIPTTVRK------------------------------------------ 657
                          |.||||.:.                                          
  Fly  2620 CHCRPGWTGPACNIPTIPTTFKAQSYVKYALSFEPDRFSTQVQLRFRTREEYGELFRVSDQHNRE 2684

Mouse   658 -------------------------------------NWTITRLN--GDYAQLSL---------- 673
                                                 .|.:.::|  |..|.|.|          
  Fly  2685 YGILEIKDGHLHFRYNLNSLRTEEKDLWLNAIVVNDGQWHVVKVNRYGSAATLELDGGEGRRYNE 2749

Mouse   674 ---------RILYLEAGVY--------------------------------DVPIIVTDSG---- 693
                     .::..:.|||                                .:|:....:|    
  Fly  2750 TFEFVGHQWLLVDKQEGVYAGGKAEYTGVRTFEVYADYQKSCLDDIRLEGKHLPLPPAMNGTQWG 2814

Mouse   694 --------------NPPLSN---------TSVIKVKVCPCDE----------------------- 712
                          |.|.||         ..:..|..|.|.|                       
  Fly  2815 QATMARNLEKGCPSNKPCSNVICPDPFECVDLWNVYECTCGEGRIMSPDSKGCMDRNECLDMPCM 2879

Mouse   713 NG-----------------------DCTTVGAVAAAGLGTGAIVAILICIVILLIMVLLFVVWMK 754
            ||                       :|..|.......|..||:.|||:|::|:||:||:|||:.:
  Fly  2880 NGATCINLEPRLRYRCICPDGFWGENCELVQEGQTLKLSMGALAAILVCLLIILILVLVFVVYNR 2944

Mouse   755 RREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQD-YDLSQLQQPEAMEHVLSKTPGVRRVDE 818
            ||  |.|.|  ...|:||||:||:.||:|||||:|.. :|::.||.|         ..|....:.
  Fly  2945 RR--EAHIK--YPGPDDDVRENIINYDDEGGGEDDMTAFDITPLQIP---------IGGPMPPEL 2996

Mouse   819 RPVGAEPQYPVRPVVP-HPGDIGDFINEGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLNS 882
            .|:.....|||..::| ...::|.||.|..:.||.||.|||:|.|..:.|||.||||||:|||.|
  Fly  2997 APMKMPIMYPVMTLMPGQEPNVGMFIEEHKKRADGDPNAPPFDDLRNYAYEGGGSTAGSLSSLAS 3061

Mouse   883 SSSGD-QDYDYLNDWGPRFKKLADMYG 908
            .:..: |:||||..|||||.|||:|||
  Fly  3062 GTDDEQQEYDYLGAWGPRFDKLANMYG 3088

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cdh4NP_033997.1 Cadherin_pro 30..119 CDD:285913 19/78 (24%)
E_set 170..270 CDD:298831 29/124 (23%)
Cadherin_repeat 278..385 CDD:206637 41/111 (37%)
Cadherin_repeat 393..500 CDD:206637 27/120 (23%)
Cadherin_repeat 511..608 CDD:206637 35/98 (36%)
E_set 616..708 CDD:298831 35/667 (5%)
Cadherin_C 766..908 CDD:279398 65/144 (45%)
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637
Cadherin_repeat 337..396 CDD:206637
E_set 449..541 CDD:298831
Cadherin_repeat 549..>625 CDD:206637
Cadherin_repeat 655..752 CDD:206637
Cadherin_repeat 765..853 CDD:206637
Cadherin_repeat 862..964 CDD:206637
Cadherin_repeat 973..1074 CDD:206637
Cadherin_repeat 1083..1166 CDD:206637
Cadherin_repeat <1219..1298 CDD:206637
Cadherin_repeat 1310..1414 CDD:206637 29/127 (23%)
Cadherin_repeat 1423..1514 CDD:206637 7/90 (8%)
Cadherin_repeat 1522..1630 CDD:206637 26/107 (24%)
Cadherin_repeat 1638..1741 CDD:206637 40/110 (36%)
Cadherin_repeat 1762..1861 CDD:206637 26/109 (24%)
Cadherin_repeat 1871..1966 CDD:206637 35/99 (35%)
Cadherin_repeat 1974..2083 CDD:206637 0/108 (0%)
EGF 2350..2380 CDD:278437 3/29 (10%)
LamG 2385..2570 CDD:238058 0/184 (0%)
EGF_2 <2605..2631 CDD:285248 0/25 (0%)
Laminin_G_2 2665..2800 CDD:280389 9/134 (7%)
EGF_CA 2869..2907 CDD:238011 2/37 (5%)
Cadherin_C 2952..3088 CDD:279398 65/144 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 130 1.000 Domainoid score I5176
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

Return to query results.
Submit another query.