DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdh15 and CadN

DIOPT Version :9

Sequence 1:	NP_031688.2	Gene:	Cdh15 / 12555	MGIID:	106672	Length:	784	Species:	Mus musculus
Sequence 2:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster

Alignment Length:	828	Identity:	219/828 - (26%)
Similarity:	331/828 - (39%)	Gaps:	236/828 - (28%)

- Green bases have known domain annotations that are detailed below.

Mouse    49 PPI---------SVSENHKRLPYPLVQIKS---DKQQLGSVIYSIQGPGVD-EEPRN-VFSIDKF 99
            ||:         ...|:.:.||..::|:.:   ||.:..:::|.:.|.|:| :.|.| .|.|::.
  Fly  1515 PPVFERPTYRTQITEEDDRNLPKRVLQVTATDGDKDRPQNIVYFLTGQGIDPDNPANSKFDINRT 1579

Mouse   100 TGRVYLNATLDREKTD---RFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQDVFRGRIL 161
            ||.:::...|||::.:   ::|...||.|.||..|....|:::.:.|.|||.|.|.|.|:.|.:.
  Fly  1580 TGEIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVT 1644

Mouse   162 EGAIPGTFVTRAEATDADDP-ETDNAALRFSI------LEQGSPEFFSIDEHTGEIRTVQVGLDR 219
            |....|..|....|.|.||| |..||.|.:||      .|.||| .|.|:..||.|:|....|||
  Fly  1645 ENGTAGMVVMTMTAVDYDDPNEGSNARLVYSIEKNVIEEETGSP-IFEIEPDTGVIKTAVCCLDR 1708

Mouse   220 EVVAVYNLTLQVADMSGDGLTATASAIISIDDINDNAPEFTKDEFFMEAAEAVSGVDVGRLEVED 284
            |....|  ::||..|.|.||..|.:|.|.:.||||..|:|||||:|.|       ||    |.:.
  Fly  1709 ERTPDY--SIQVVAMDGGGLKGTGTASIRVKDINDMPPQFTKDEWFTE-------VD----ETDG 1760

Mouse   285 KDLPGSPNWVARFTILEGDPDGQFKI------------YTDPKTNEGV--LSVVKPLDYESREQ- 334
            ..||..|  :...|:.:.|...:|:.            :|..:.|:|.  |.:|:|||||.:.|
  Fly  1761 TALPEMP--ILTVTVHDEDETNKFQYKVIDNSGYGADKFTMVRNNDGTGSLKIVQPLDYEDQLQS 1823

Mouse   335 --YELRVSVQNEAPLQAAAPRARRGQTR-----------VSVWVQDTNE-APVFPENPLRTSIAE 385
              :..|:.|.:            :|:..           |.|.::|.|: .|.|....:..|:.|
  Fly  1824 NGFRFRIQVND------------KGEDNDNDKYHVAYSWVVVKLRDINDNKPHFERANVEVSVFE 1876

Mouse   386 GAPPGTSVATFSARDPDTEQLQRISYSKDYDPEDWLQ-VDGATGRIQTQRVLS----PASPFLKD 445
            ....||.:..|.|.|||.....::|||.|...:...| .....|.:..||.|.    |.
  Fly  1877 DTKVGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQFAINQNGSVTIQRSLDREVVPR------ 1935

Mouse   446 GWYRAIILALDNAIPPSTATGTLSIEILEVNDHAPALALPPSGSLCSEPDQGPG---LLLGATDE 507
              ::..|||:|:..||.|||.||::.:.::||:||.........|   |:..|.   :.:.|||:
  Fly  1936 --HQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKDYRPVL---PEHVPPRKVVEILATDD 1995

Mouse   508 D--LPPHGAPFHFQLNPRVPDLGR-NWSVSQIN----------VSHARLRLRHQVSEGLHRLSLL 559
            |  ...:|.||.|:|:|...|:.| ::.|.|..          :|..|...|.|..|  :.:.::
  Fly  1996 DDRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISSLRSFDREQQKE--YMIPIV 2058

Mouse   560 LQDSGEPPQQREQTLNVTVCRCG--SDGTCLPGAAALRGGGVGVSLGALVIVLASTVVLLVLILL 622
            ::|.|.|......||.|.:   |  :|....||:
  Fly  2059 IKDHGSPAMTGTSTLTVII---GDVNDNKMQPGS------------------------------- 2089

Mouse   623 AALRTRFRGHSRGKSLLHGLQEDLRDNILNYDEQGGGEE---------DQDAYDI-------NQL 671
                                     .:|..|:.||...:         |.|.:|:       ..:
  Fly  2090 -------------------------KDIFVYNYQGQSPDTPIGRVYVYDLDDWDLPDKKFYWEAM 2129

Mouse   672 RHP----------VEPRATSRSLGRPPLRRDAPFSYVPQPHRVLPTSPSDI-ANFISDGLEAADS 725
            .||          |..||.:|. ||..||    |....:.|     :.:|| ||......|.
  Fly  2130 EHPRFKLDEDSGMVTMRAGTRE-GRYHLR----FKVYDRKH-----TQTDIPANVTVTVREI--- 2181

Mouse   726 DPSVPPYDTALIYDYEGDGSVAGTLSSILSSLGDEDQDYDYLRDWGPR 773
                 |::..:     ..|||.      ||.:.||    |::|.|..|
  Fly  2182 -----PHEAVV-----NSGSVR------LSGISDE----DFIRVWNYR 2209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdh15	NP_031688.2	Cadherin_repeat	51..147	CDD:206637	29/112 (26%)
		Cadherin_repeat	155..255	CDD:206637	43/106 (41%)
		Cadherin	270..366	CDD:278457	25/123 (20%)
		Cadherin_repeat	378..478	CDD:206637	31/104 (30%)
		Cadherin	486..579	CDD:278457	28/108 (26%)
		Cadherin_C	639..782	CDD:279398	36/162 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..700		8/23 (35%)
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637	29/107 (27%)
		Cadherin_repeat	1638..1741	CDD:206637	42/105 (40%)
		Cadherin_repeat	1762..1861	CDD:206637	24/112 (21%)
		Cadherin_repeat	1871..1966	CDD:206637	31/102 (30%)
		Cadherin_repeat	1974..2083	CDD:206637	29/116 (25%)
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8035
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.860