DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdc45 and Cdc45

DIOPT Version :9

Sequence 1:	NP_001345135.1	Gene:	Cdc45 / 12544	MGIID:	1338073	Length:	566	Species:	Mus musculus
Sequence 2:	NP_569880.1	Gene:	Cdc45 / 31052	FlyBaseID:	FBgn0026143	Length:	575	Species:	Drosophila melanogaster

Alignment Length:	583	Identity:	231/583 - (39%)
Similarity:	366/583 - (62%)	Gaps:	25/583 - (4%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MFVTDFRKEFYETVHNQRVLLFVASDVDALCACKILQALFQCDHVQYTLVPVSGWQELETAYLEH 65
            |||.|.|.:||..:..:|:|:.|..|:||:||.:||||||:.||:.||:||:.|...|:.||.||
  Fly     1 MFVQDLRNDFYRQLVGKRILIVVNYDIDAICASRILQALFKYDHMLYTVVPIMGVTGLKRAYGEH 65

Mouse    66 KEQFSYFILINCGANVDLLDILQPDEDSIFFVCDTHRPVNVVNVYNDTQIKLLIKQEDDLEVPAY 130
            :....|.:|:|||..||::::|||.:|..||:||:|||::|.|:|:|.|:.:|.....:..:||:
  Fly    66 QGDVKYVVLVNCGGCVDIVELLQPSDDVTFFICDSHRPLDVCNIYSDRQVCILGDASLEENIPAF 130

Mouse   131 DDIFRD-EAEDED---------------LSDSDGDGSEP-SEKRTRLEEEIVERNRKRRQRREWE 178
            :.||.| |.||||               ..:||.:...| |.|.:|||.. .:|..|:|.||:||
  Fly   131 ETIFYDSEGEDEDEDESSDTEQQHDDSGAGESDQEDQAPRSRKLSRLERH-EQRILKQRARRQWE 194

Mouse   179 ARRKDILFDYEQYEYYGTSSAMVMFDLAWMMSKDLNDMLWWAIVGLTDQWVHDKITQMKYVTDVG 243
            :.|..|:|:|.|:.|||.|:|:::|:|||.:|||..|:|||||||:|:|.:..||....|..::.
  Fly   195 SERDRIMFEYTQFSYYGRSAALMVFELAWKLSKDNMDLLWWAIVGITEQLLLGKIESGAYTLELE 259

Mouse   244 ILQRHVSRHNHRNEAEENMLSVDCTRISFEYDLCLVLYQHWSLHESLYNTSYTAARFKLWSVHGQ 308
            .:|.||||..::.. ::|.:|  .::|:||.||.||||:||.:.||:..:.|::.:.|||::.|:
  Fly   260 QIQSHVSRLTNKTN-DQNTMS--ASKITFENDLHLVLYRHWPVTESMRYSRYSSCQLKLWTLRGE 321

Mouse   309 KRLQEFLADMGLPLKQVKQKFQSMDVSLKGNLREMIEESANKFGMKDMRVQTFSIQFGFKHKFLA 373
            |||.|.|.:|||||...:|.:.:||:.|:.....|:|..|.|:.:.|:...||::.:|::.::.|
  Fly   322 KRLHELLLEMGLPLVHARQTYGAMDLVLRKEFFSMVERLAEKYDIADIVYGTFTLSYGYRSRYAA 386

Mouse   374 SDVVFATMSLMESPEKDGSGTDHFIQALDSLSRSNLDKLYLGLELAKKHLQATQQTIASCLCTNL 438
            :|.|:|.:::|||.:|..:..|.|::|.|:|||.:...|..|::.||....|..:.:.|.|....
  Fly   387 ADYVYALLAIMESVKKHKTPEDCFLEASDALSRQHKQLLSAGIDQAKLLHAAVFRQVQSSLEARQ 451

Mouse   439 VTSQGPFLYCSLMEGTPDVTLFSKPASLSLLSRHLLKSFVYSTKNRRCKLLPLVMAAPLSVEQGT 503
            |.|.|.|.|..|.|   :...||.|.:|.||:|.||:..|.:::.|:...|||:.:.||:..:|.
  Fly   452 VHSAGSFFYYVLQE---EHAFFSYPYALGLLARFLLRGHVATSRARQASDLPLIASCPLNASEGM 513

Mouse   504 VTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRTLHNYFDLSVIELKAEDRSKFLDALVSLLS 566
            ..:|||.|..:.|.| ||||:|||:||:.:....|.::|:.:|::|:..|.::|||:|..||:
  Fly   514 CLLVGIVPVREDSPR-NFFGKAFEQAAQKSGVALLQDFFEPAVVQLRQSDLTRFLDSLTVLLA 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc45	NP_001345135.1	CDC45	19..561	CDD:397026	220/558 (39%)
Cdc45	NP_001345135.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..161		10/38 (26%)
Cdc45	NP_569880.1	CDC45	19..571	CDD:367156	223/565 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841564
Domainoid	1	1.000	302	1.000	Domainoid score	I1405
eggNOG	1	0.900	-	-		E1_KOG2475
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2616
Inparanoid	1	1.050	435	1.000	Inparanoid score	I1685
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53772
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004931
OrthoInspector	1	1.000	-	-		oto92010
orthoMCL	1	0.900	-	-		OOG6_102930
Panther	1	1.100	-	-	LDO	PTHR10507
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4027
SonicParanoid	1	1.000	-	-		X4597
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790