DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cd63 and Tsp74F

DIOPT Version :9

Sequence 1:	NP_001036045.1	Gene:	Cd63 / 12512	MGIID:	99529	Length:	238	Species:	Mus musculus
Sequence 2:	NP_524132.1	Gene:	Tsp74F / 39995	FlyBaseID:	FBgn0036769	Length:	236	Species:	Drosophila melanogaster

Alignment Length:	234	Identity:	62/234 - (26%)
Similarity:	110/234 - (47%)	Gaps:	19/234 - (8%)

- Green bases have known domain annotations that are detailed below.

Mouse     9 CVKFLLYVLLLA-FCACAVGLIAIGVAVQVVLKQAITHETTAGSLLP---VVIIAVGAFLFLVAF 69
            |.:|:.|.|.:| |.....|.|...:.:..::.::..:|....:|..   .|::.....:.||:|
  Fly    10 CGQFVKYSLFIANFVIFVGGAIVFCLTLWTLVDRSFVNELLGTNLFSGAVYVLLVTSIIICLVSF 74

Mouse    70 VGCCGACKENYCLMITFAIFLSLIMLVEVAVAIAGYVFRDQVKSEFNKSFQQQMQNYLKDNKTAT 134
            :||.||.||..||::|:.|.::|:.:..:...:.|||||::|:....:..:..|..|....:...
  Fly    75 LGCVGAGKEVKCLLLTYFIIVALVFVTMLIGGVLGYVFRERVQQTMRQEMRSTMALYGSRREITQ 139

Mouse   135 ILDKLQKENNCCGASNYTDWENIPGMAKDRVPDSCCINITVGCGNDFKESTI-------HTQGCV 192
            ..|..|:...|||...:.||...     ..||:|||..:   .|...||.||       :.|||:
  Fly   140 AWDLTQERLQCCGVDTWHDWNRY-----GPVPESCCQEL---FGGQRKECTIFPTITNLYNQGCL 196

Mouse   193 ETIAIWLRKNILLVAAAALGIAFVEVLGIIFSCCLVKSI 231
            .....::|.:..::...::.:|.:.:.|:||||.|...|
  Fly   197 YVTTNFIRDHAAVIGGTSIAVAILMIFGMIFSCLLFNMI 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cd63	NP_001036045.1	Tetraspannin	10..227	CDD:395265	59/227 (26%)
		CD63_LEL	105..203	CDD:239419	28/104 (27%)
		Lysosomal targeting motif. /evidence=ECO:0000269\|PubMed:21041449	234..238
Tsp74F	NP_524132.1	Tetraspannin	14..231	CDD:395265	58/224 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3882
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4418
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840