DRSC/TRiP Functional Genomics Resources

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Protein Alignment WDR81 and SWD3

DIOPT Version :10

Sequence 1:NP_001157281.1 Gene:WDR81 / 124997 HGNCID:26600 Length:1941 Species:Homo sapiens
Sequence 2:NP_009734.1 Gene:SWD3 / 852472 SGDID:S000000379 Length:315 Species:Saccharomyces cerevisiae


Alignment Length:277 Identity:56/277 - (20%)
Similarity:98/277 - (35%) Gaps:83/277 - (29%)


- Green bases have known domain annotations that are detailed below.


Human  1641 LQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLYNYG-----DGTSETAPRLVYTQHRKSV 1700
            |.:|.||:..|..:......:...:.|.|.::::|...|..     ...||....:....:..|:
Yeast    89 LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSI 153

Human  1701 FFVGQLEAPQHVVSCDGAVHVWDPFTGKTLRTV------EPLDSRVPLTAVAVMPAPHTSITMAS 1759
            ...|         |.||.:.::|..||..|:|:      :..:..||::.|....... .:.:.|
Yeast   154 LSSG---------SYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENAR-YLLVKS 208

Human  1760 SDSTLRFVDCRKPGLQHEFRLGGGLNPGLVRALAISPSGRSVVAGFSSG--FMVLLDTRTGLVLR 1822
            .|..::..||          :||    .:||...:.|..:.|: ..|.|  |:...|..|.||:.
Yeast   209 LDGVVKIWDC----------IGG----CVVRTFQVQPLEKGVL-HHSCGMDFLNPEDGSTPLVIS 258

Human  1823 G--------WPAHEGDILQIKAVEGSVLVSSSSDHSLTVWKELEQKPTHHYKSASDPIHTFDLYG 1879
            |        |.:....:||:  ::||:                     :|:.|....||.|    
Yeast   259 GYENGDIYCWNSDTKSLLQL--LDGSL---------------------YHHSSPVMSIHCF---- 296

Human  1880 SEVVTGTVSNKIGVCSL 1896
                 |.:     :|||
Yeast   297 -----GNI-----MCSL 303

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WDR81NP_001157281.1 Necessary and sufficient for the interaction with SQSTM1. /evidence=ECO:0000269|PubMed:28404643 1..650
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27
Beach 351..591 CDD:100117
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 618..637
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 694..718
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1022..1074
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1097..1217
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1523..1556
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1569..1602
WD 1 1639..1677 8/35 (23%)
WD40 <1640..1939 CDD:441893 56/277 (20%)
WD40 repeat 1652..1695 CDD:293791 6/47 (13%)
WD 2 1686..1724 6/37 (16%)
WD40 repeat 1700..1734 CDD:293791 9/39 (23%)
WD 3 1729..1769 7/45 (16%)
WD40 repeat 1743..1779 CDD:293791 5/35 (14%)
WD 4 1777..1815 9/39 (23%)
WD40 repeat 1789..1822 CDD:293791 11/34 (32%)
WD 5 1819..1856 8/44 (18%)
WD40 repeat 1831..1864 CDD:293791 4/32 (13%)
WD 6 1860..1896 7/35 (20%)
WD40 repeat 1871..1893 CDD:293791 4/21 (19%)
WD 7 1902..1941
SWD3NP_009734.1 WD40 repeat 17..53 CDD:293791
WD40 <21..293 CDD:441893 49/251 (20%)
WD40 repeat 59..94 CDD:293791 2/4 (50%)
WD40 repeat 99..135 CDD:293791 5/35 (14%)
WD40 repeat 142..178 CDD:293791 10/44 (23%)
WD40 repeat 192..228 CDD:293791 9/50 (18%)
WD40 repeat 236..284 CDD:293791 14/71 (20%)
WD40 repeat 290..312 CDD:293791 7/28 (25%)
Blue background indicates that the domain is not in the aligned region.

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