DRSC/TRiP Functional Genomics Resources

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Protein Alignment WDR81 and SPT8

DIOPT Version :10

Sequence 1:NP_001157281.1 Gene:WDR81 / 124997 HGNCID:26600 Length:1941 Species:Homo sapiens
Sequence 2:NP_013156.1 Gene:SPT8 / 850744 SGDID:S000004045 Length:602 Species:Saccharomyces cerevisiae


Alignment Length:867 Identity:136/867 - (15%)
Similarity:233/867 - (26%) Gaps:446/867 - (51%)


- Green bases have known domain annotations that are detailed below.


Human  1133 DKSSLRSG---DSSQDLK-QSEGSEEEEEEEDSCVVLEEEEGEQEEVTGASELTLSDTVLSMETV 1193
            |...:.||   ||.|||: ..:|.|:||:::|.    :|::.:.|:                   
Yeast    19 DDEEMLSGLENDSKQDLEGNDDGGEDEEDDDDD----DEDDDDDED------------------- 60

Human  1194 VAGGSGGDGEEEEEALPEQSEGKEQKILLDTACKMVRWLSAKLGPTVASRHVARNLLRLLTSCYV 1258
                     |.|::...|..:|::....:|....          ||...:|              
Yeast    61 ---------EREDDDEQEDDDGEDDAARMDKTAT----------PTNEHQH-------------- 92

Human  1259 GPTRQQFTVSSGESPPLSAGN----IYQKRPVLGDI---VSGPVLSCLLHIARLYGEPVLTYQYL 1316
               .:|...::|......:|:    |..:...|.|:   |.....|...|.|...||   .|:|.
Yeast    93 ---DEQKAAAAGAGGAGDSGDAVTKIGSEDVKLSDVDGGVGSREASSSTHEASANGE---VYEYY 151

Human  1317 PYI--------SYLVAPGSASGPSRLNSRKEAGLLAAVTLTQKIIVYLSDTTLMDILPRISHEVL 1373
            .::        ||.:.|.:|                                    :|..:|...
Yeast   152 KHMLNAAQIADSYNIYPTAA------------------------------------IPIQTHVNA 180

Human  1374 LPVLSFLTSLVTGFPSGAQARTILCVKTISLIALICLRIGQEMVQQH-LSEPV--ATFFQVFSQL 1435
            |.|...|..|..|...|       .::...|:..:..::...::|:| |:|.:  |...|.:   
Yeast   181 LAVSRGLKYLFLGGSDG-------YIRKYDLLNTLEGKLSLTILQKHSLAESIQNAGILQSY--- 235

Human  1436 HELRQQDLKLDPAGRGEGQLPQVVFSDGQQRPVDPALLDELQKVFTLEMAYTIYVPFSCLLGDII 1500
                           .|.::||                  .:....|....|.|.|         
Yeast   236 ---------------WENEIPQ------------------KKSEMKLSANKTDYEP--------- 258

Human  1501 RKIIPNHELVGELAALYLESISPSSRNPASVEPTMPGTGPEWDPHGGGCPQDDGHSGTFGSVLVG 1565
             |:.|.|.|..:...|::                                               
Yeast   259 -KVSPVHSLEVQSECLFI----------------------------------------------- 275

Human  1566 NRIQIPNDSRPENPGPLGPISGVGGGGLGSGSDDNALKQELPRSVHGLSGNWLAYWQYEIGVSQQ 1630
                               :||:..||:               ::.|     :.|.:..|     
Yeast   276 -------------------LSGLQNGGI---------------TMQG-----VRYMEGSI----- 296

Human  1631 DAHFHFHQIRLQSFPGHSGAVKCVAPL---SSEDFFLSGSKDRTVRLW----------------- 1675
             ||:         |.|.:|..:.|..|   ..||.|||||.|:.:..|                 
Yeast   297 -AHY---------FKGRNGHTQIVNILRLNGQEDRFLSGSWDKRLLEWDLQTGDIVNEFKKSRSE 351

Human  1676 -------PLYN------------------------------------------YGDGT------- 1684
                   |||:                                          .|||:       
Yeast   352 LSSLEMRPLYSSVDVSGNVNSGKENENADDDMDSLFGDEDEDEKQDAGNEPVETGDGSNGEENKE 416

Human  1685 --SETAPRLVYTQHRKSVFFVGQLEAPQHVVSCDGAVHVWD------------------------ 1723
              ||.:..:||.:   |||....|         :|:||:||                        
Yeast   417 QISEESLNIVYDE---SVFMTSGL---------NGSVHIWDRRMTQSPALSLERGAGVPPWCLSA 469

Human  1724 --------PFTGKTLRTVEPLDSRV---------------PLTAVAVMP--------------AP 1751
                    .:.|:....||..|.::               |::.|..||              ..
Yeast   470 CWGVDGDHVYAGRRNACVEQFDLKMPSKPIHNLKLPSISGPVSCVKAMPNNKHLLCASRDNIRLY 534

Human  1752 HTSITMASSDSTLRFVDCRKPGLQHEFRLGGGLNPGLVRALAISPSGRSVVAGFSSGFMVLLDTR 1816
            :..|.:.:|:||.:  ..:.|     |.:..|.:.|::..|.:.|:.|.:::  :||        
Yeast   535 NVEIAVDASNSTTK--SSKVP-----FLIVPGHHGGIISNLYLDPTSRFIIS--TSG-------- 582

Human  1817 TGLVLRGWPAHEGDILQIKAVE 1838
                .|||..:..|...|..::
Yeast   583 ----NRGWQGNSTDTTLIYDID 600

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WDR81NP_001157281.1 Necessary and sufficient for the interaction with SQSTM1. /evidence=ECO:0000269|PubMed:28404643 1..650
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27
Beach 351..591 CDD:100117
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 618..637
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 694..718
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1022..1074
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1097..1217 19/87 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1523..1556 0/32 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1569..1602 4/32 (13%)
WD 1 1639..1677 14/64 (22%)
WD40 <1640..1939 CDD:441893 59/338 (17%)
WD40 repeat 1652..1695 CDD:293791 21/120 (18%)
WD 2 1686..1724 12/69 (17%)
WD40 repeat 1700..1734 CDD:293791 9/65 (14%)
WD 3 1729..1769 11/68 (16%)
WD40 repeat 1743..1779 CDD:293791 8/49 (16%)
WD 4 1777..1815 8/37 (22%)
WD40 repeat 1789..1822 CDD:293791 5/32 (16%)
WD 5 1819..1856 5/20 (25%)
WD40 repeat 1831..1864 CDD:293791 1/8 (13%)
WD 6 1860..1896
WD40 repeat 1871..1893 CDD:293791
WD 7 1902..1941
SPT8NP_013156.1 WD40 178..>355 CDD:475233 48/330 (15%)
WD40 repeat 180..218 CDD:293791 7/44 (16%)
WD40 repeat 264..302 CDD:293791 13/138 (9%)
WD40 304..593 CDD:475233 55/321 (17%)
WD40 repeat 310..346 CDD:293791 11/35 (31%)
WD40 repeat 353..408 CDD:293791 4/54 (7%)
WD40 repeat 362..457 CDD:293791 16/106 (15%)
WD40 repeat 464..503 CDD:293791 4/38 (11%)
WD40 repeat 511..558 CDD:293791 9/53 (17%)
Blue background indicates that the domain is not in the aligned region.

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