DRSC/TRiP Functional Genomics Resources

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Protein Alignment WDR81 and TUP1

DIOPT Version :10

Sequence 1:NP_001157281.1 Gene:WDR81 / 124997 HGNCID:26600 Length:1941 Species:Homo sapiens
Sequence 2:NP_010007.1 Gene:TUP1 / 850445 SGDID:S000000680 Length:713 Species:Saccharomyces cerevisiae


Alignment Length:786 Identity:153/786 - (19%)
Similarity:245/786 - (31%) Gaps:270/786 - (34%)


- Green bases have known domain annotations that are detailed below.


Human  1010 QVLAGAEASQEESKD-------LAGAAEEEESGLPGAGPGSCAFGEEIPMDGEPPASSGLGLPDY 1067
            |.||.|.||...::.       .|..|....:|.|.|          .|:....|...|..||..
Yeast   117 QQLAAASASVPVAQQPPATTSATATPAANTTTGSPSA----------FPVQASRPNLVGSQLPTT 171

Human  1068 T-SGVSFHDQADLPETEDFQAGLYVTESPQPQEAEAVSLGRLSDKSSTSETSLGEERAPDEGGAP 1131
            | ..||.:.|..||: :..|......:.|.||    ||:..||:      |::        .|:|
Yeast   172 TLPVVSSNAQQQLPQ-QQLQQQQLQQQQPPPQ----VSVAPLSN------TAI--------NGSP 217

Human  1132 VDKSSLRSGDSSQDLKQSEGSEEEEEEEDSCVVLEEEEGEQEEVTGASELTLSDTVLSMETVVAG 1196
            ..|.:    .:...:|..|.:.:|.|.|::         ...::......|.:.|..:.||.:. 
Yeast   218 TSKET----TTLPSVKAPESTLKETEPENN---------NTSKINDTGSATTATTTTATETEIK- 268

Human  1197 GSGGDGEEEEEALPEQSEGKEQKILLDTACKMVRWLSAKLGPTVASRHVARNLLRLLTSCYVGPT 1261
                  .:||:|.|                              ||.|         ...|:.|.
Yeast   269 ------PKEEDATP------------------------------ASLH---------QDHYLVPY 288

Human  1262 RQQFTVSSGESPPLSAGNIYQKRPVLGDIVSGPVLSCL----------------------LHIAR 1304
            .|:    :..|.|:.        |.|.|:.|..|...|                      ||.:.
Yeast   289 NQR----ANHSKPIP--------PFLLDLDSQSVPDALKKQTNDYYILYNPALPREIDVELHKSL 341

Human  1305 LYGEPVLTYQYLPYISYLVAPGSASGPSRLNS--RKEAGLLAAVTLTQKIIVYLSDTTLMDILPR 1367
            .:...|...::.....||     |:|.::...  |...|.|.|         .|||.:..:    
Yeast   342 DHTSVVCCVKFSNDGEYL-----ATGCNKTTQVYRVSDGSLVA---------RLSDDSAAN---- 388

Human  1368 ISHEVLLPVLSFLTSLVTGFPSGAQARTILCVKTISLIALICLRIGQEMVQQHLSEPVATFFQVF 1432
             :|.      :.:|...|...:.....|.....||:..|:..        ...|::.|.......
Yeast   389 -NHR------NSITENNTTTSTDNNTMTTTTTTTITTTAMTS--------AAELAKDVENLNTSS 438

Human  1433 SQLHELRQQDLKLDPAGRGEGQLPQVVFSDGQQRPVDPALLDELQKVFTLEMAYTIYVPFSCLLG 1497
            |...:|..:.:...|.|:        ..:.|.:        |.|.:::.:|.             
Yeast   439 SPSSDLYIRSVCFSPDGK--------FLATGAE--------DRLIRIWDIEN------------- 474

Human  1498 DIIRKIIPNHELVGELAALYLESISPSSRNPASVEPTMPGTGPE----WDPHGGGCPQ----DDG 1554
               |||:  ..|.|....:|.....||.      :..:.|:|..    ||...|.|..    :||
Yeast   475 ---RKIV--MILQGHEQDIYSLDYFPSG------DKLVSGSGDRTVRIWDLRTGQCSLTLSIEDG 528

Human  1555 HSGTFGSVLVGNRIQIPNDSRPENPGPLGPISGVGGGGLGSGSDDNALKQELPRSVHGLSGNWLA 1619
            .:    :|.|             :||        .|..:.:||.|.|::                
Yeast   529 VT----TVAV-------------SPG--------DGKYIAAGSLDRAVR---------------- 552

Human  1620 YWQYEIG--VSQQDAHFHFHQIRLQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLYNYGD 1682
            .|..|.|  |.:.|:       ..:|..||..:|..|.........:|||.||:|:||.|.|..:
Yeast   553 VWDSETGFLVERLDS-------ENESGTGHKDSVYSVVFTRDGQSVVSGSLDRSVKLWNLQNANN 610

Human  1683 GTSETAP-----RLVYTQHRKSVFFVGQLEAPQHVV--SCDGAVHVWDPFTGKTLRTVEPLDSRV 1740
            .:....|     .:.|..|:..|..|...:..::::  |.|..|..||..:|..|..::...:.|
Yeast   611 KSDSKTPNSGTCEVTYIGHKDFVLSVATTQNDEYILSGSKDRGVLFWDKKSGNPLLMLQGHRNSV 675

Human  1741 PLTAVA 1746
            ...|||
Yeast   676 ISVAVA 681

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WDR81NP_001157281.1 Necessary and sufficient for the interaction with SQSTM1. /evidence=ECO:0000269|PubMed:28404643 1..650
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27
Beach 351..591 CDD:100117
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 618..637
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 694..718
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1022..1074 13/59 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1097..1217 23/119 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1523..1556 10/40 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1569..1602 6/32 (19%)
WD 1 1639..1677 13/37 (35%)
WD40 <1640..1939 CDD:441893 31/114 (27%)
WD40 repeat 1652..1695 CDD:293791 13/47 (28%)
WD 2 1686..1724 9/44 (20%)
WD40 repeat 1700..1734 CDD:293791 9/35 (26%)
WD 3 1729..1769 5/18 (28%)
WD40 repeat 1743..1779 CDD:293791 3/4 (75%)
WD 4 1777..1815
WD40 repeat 1789..1822 CDD:293791
WD 5 1819..1856
WD40 repeat 1831..1864 CDD:293791
WD 6 1860..1896
WD40 repeat 1871..1893 CDD:293791
WD 7 1902..1941
TUP1NP_010007.1 Tup_N 11..88 CDD:400755
WD40 343..706 CDD:238121 90/460 (20%)
WD40 repeat 347..383 CDD:293791 10/49 (20%)
WD40 repeat 394..438 CDD:293791 8/51 (16%)
WD40 repeat 447..483 CDD:293791 10/69 (14%)
WD40 repeat 488..523 CDD:293791 9/40 (23%)
WD40 repeat 530..566 CDD:293791 13/76 (17%)
WD40 repeat 579..627 CDD:293791 13/47 (28%)
WD40 repeat 633..669 CDD:293791 9/35 (26%)
WD40 repeat 675..705 CDD:293791 4/7 (57%)
Blue background indicates that the domain is not in the aligned region.

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