DRSC/TRiP Functional Genomics Resources

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Protein Alignment WDR81 and BPH1

DIOPT Version :10

Sequence 1:NP_001157281.1 Gene:WDR81 / 124997 HGNCID:26600 Length:1941 Species:Homo sapiens
Sequence 2:NP_009961.2 Gene:BPH1 / 850398 SGDID:S000000628 Length:2167 Species:Saccharomyces cerevisiae


Alignment Length:450 Identity:113/450 - (25%)
Similarity:176/450 - (39%) Gaps:117/450 - (26%)


- Green bases have known domain annotations that are detailed below.


Human   223 ALLESPEM----LYVVHPYVQFSLHDV--VTFSPAKLTNSQAKVLF--------------ILFRV 267
            :|:..|::    .::.|....:.|.|:  ||..|..|.:...::||              :...|
Yeast  1430 SLINGPDVKRVSTFLKHEVFVWKLLDITFVTKRPFLLRDVAIELLFKERVSAFFSFYNKRVRDDV 1494

Human   268 LRAMDACHRQGLACGALSLYHIAVDEKLCSELRLDLSAYERPEEDENEEAPVARD---EAGIVSQ 329
            ||.::...:           |:..|....|.|:         |.::...:.|||:   :|.|.|:
Yeast  1495 LRVLNKIPK-----------HLPADPIFSSVLQ---------EINDRGNSIVARNGIGKASIASK 1539

Human   330 EEQGGQPGQPTGQEELRSLVLD-------WVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVV 387
            .         |......:.::|       ||.|.||||:||:.:|.||||...|...:||.|||:
Yeast  1540 F---------TSVFSANNSLIDGFEISKKWVRGEISNFYYLLSINILAGRSFNDLTQYPVFPWVI 1595

Human   388 --------DFTTPHGRFRDLRKSKFRLNKGDKQLDF--TYEMTRQAFVAGGAGGGEPPHVPHHIS 442
                    |...|. .:|||.| ........::|.|  .||.......|..|    |.|...|.|
Yeast  1596 ADYESNVLDLENPK-TYRDLSK-PMGAQSEKRKLQFIERYEALASLENADSA----PFHYGTHYS 1654

Human   443 DVLSDITYYVYKARRTPRSVLCGHVRAQWEPHEYPASMERMQNW-------TPD--ECIPEFYTD 498
            ..:. ::.|:.:.:....|.|.....:........:|:||.  |       |.|  |..|||:..
Yeast  1655 SAMI-VSSYLIRLKPFVESFLLLQGGSFGPADRLFSSLERA--WSSASSENTTDVRELTPEFFFL 1716

Human   499 PSIFRSIH----------PDMPDLDVPAWCSSSQE-FVAAHRALLESREVSRDLHHWIDLTFGYK 552
            |....:::          ..:.|:.:|.|.:...: |:..:|..|||..||..||.||||.||||
Yeast  1717 PEFLINVNSYDFGTDQSGKKVDDVVLPPWANGDPKVFIQKNREALESPYVSAHLHEWIDLIFGYK 1781

Human   553 LQGKEAVKEKNVCLHLV-----------DAHTHLASYGVV--------QLFDQPHPQRLA 593
            .:|..|||..||...|.           |.:...|..|::        |:|.:|||:::|
Yeast  1782 QKGDIAVKSVNVFNRLSYPGAVNLDNIDDENERRAITGIIHNFGQTPLQIFQEPHPEKIA 1841

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WDR81NP_001157281.1 Necessary and sufficient for the interaction with SQSTM1. /evidence=ECO:0000269|PubMed:28404643 1..650 112/449 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27
Beach 351..591 CDD:100117 86/295 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 618..637
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 694..718
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1022..1074
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1097..1217
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1523..1556
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1569..1602
WD 1 1639..1677
WD40 <1640..1939 CDD:441893
WD40 repeat 1652..1695 CDD:293791
WD 2 1686..1724
WD40 repeat 1700..1734 CDD:293791
WD 3 1729..1769
WD40 repeat 1743..1779 CDD:293791
WD 4 1777..1815
WD40 repeat 1789..1822 CDD:293791
WD 5 1819..1856
WD40 repeat 1831..1864 CDD:293791
WD 6 1860..1896
WD40 repeat 1871..1893 CDD:293791
WD 7 1902..1941
BPH1NP_009961.2 PH_BEACH 1371..1500 CDD:275391 14/69 (20%)
Beach 1558..1839 CDD:214982 85/289 (29%)
WD40 repeat 1933..1976 CDD:293791
WD40 repeat 1981..2017 CDD:293791
WD40 repeat 2021..2055 CDD:293791
Blue background indicates that the domain is not in the aligned region.

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