DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment WDR81 and sorf-2

DIOPT Version :10

Sequence 1:NP_001157281.1 Gene:WDR81 / 124997 HGNCID:26600 Length:1941 Species:Homo sapiens
Sequence 2:NP_001367877.1 Gene:sorf-2 / 3565037 WormBaseID:WBGene00018672 Length:1382 Species:Caenorhabditis elegans


Alignment Length:1887 Identity:403/1887 - (21%)
Similarity:647/1887 - (34%) Gaps:678/1887 - (35%)


- Green bases have known domain annotations that are detailed below.


Human   176 SVRQALQRVYGCSFLPVGETTQCPSYAREGPCPPRGSPACPSLLRAEALLESPEMLYVVHPYVQF 240
            ::.:..:::...||.|:.:..: ....:.|.|.|..|.....:.:...:.|.   |.:.|.....
 Worm    51 ALEKEFEKLLNTSFDPLMDYEE-HQRVKNGVCSPAKSTKLDWITKWANIAEK---LSISHINCSK 111

Human   241 SLHDVVTFSPAKLTNSQAKVLFILF--------------------RVLR---------AMDACHR 276
            :.|..:.|...::..:...:|.|..                    .|||         ::...| 
 Worm   112 APHKTINFQRLQILPNMTSILAIAHTEADNVILIYGHTKEGIDFQTVLRHSYSNIPDGSLQTIH- 175

Human   277 QGLACGALSLYHIAVDEKLCSE-------------LRLDLSAYERP--EEDENEEAP-VARDEAG 325
             .|....|.||......|:.:|             |:.|:.|   |  |:.....|| :..||| 
 Worm   176 -FLTKNLLDLYSQLFSRKITAEFKTRHFRCLPSFWLQYDVLA---PIFEQFRAPRAPRIPLDEA- 235

Human   326 IVSQEEQGGQPGQPTGQEELRSLVLDWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVVDFT 390
                                   ..:|.:.:..|:.||..||.:.||.:|:.:.||:.|||.||:
 Worm   236 -----------------------TSNWANRKWENYQYLTYLNDITGRVRGEVHNHPIFPWVCDFS 277

Human   391 TPHGRFRDLRKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGGGEPPHVPHHISDVLSDITYYVYKA 455
            ..:|.||.|.::|:||.|||.||...|..             ||   .||:.::||||.|.||:|
 Worm   278 EENGGFRQLNRTKYRLCKGDDQLREMYSR-------------EP---SHHVPELLSDIGYMVYRA 326

Human   456 RRTPRSVLCGHVRAQWEPHEYPASMERMQNWTPDECIPEFYTDPSIFRSIHPDMPDLDVPAWCSS 520
            |..|:..||.|||.:|.|.|||::|.||..|||||||||||.|||||.|.||||.||..|.:.||
 Worm   327 RVEPKDNLCRHVRRKWVPEEYPSTMSRMYQWTPDECIPEFYDDPSIFNSCHPDMADLRFPEFVSS 391

Human   521 SQEFVAAHRALLESREVSRDLHHWIDLTFGYKLQGKEAVKEKNVCLHLVDAHTH-LASYGVVQLF 584
            .|||:..||.:||..|||.:||.||||.||:.|....:....|:.|..|:.:.. |.:.|:||||
 Worm   392 PQEFIEWHRKMLEHEEVSMNLHRWIDLVFGFNLAIDNSKNALNLHLCFVEKNRRGLRTTGMVQLF 456

Human   585 DQPHPQRLAGAPALAPEPPL--IPKLLVQTIQETTGREDFTENPGQLPNGVGRPVLEATPCEASW 647
            ::|||.|:          ||  .|||                                       
 Worm   457 NRPHPIRM----------PLNYDPKL--------------------------------------- 472

Human   648 TRDRPVAGEDDLEQATEALDSISLAGKAGDQLGSSSQASPGLLSFSVASASRPGRRNKAAGADPG 712
                     |:.....|:                        ..|.:.|..|     |....:|.
 Worm   473 ---------DNYHLKMES------------------------FGFGMTSEHR-----KEPEVEPD 499

Human   713 EGEEGRILLPEGFNPMQALEELEKTGNF--------------LAKGLGGLLEVPEQPRVQPAVPL 763
            |....:|     :..::.:..|.....|              ||..|.|..:.|:..|       
 Worm   500 EDSHYQI-----YQKIKKVRRLRHNTYFSSMVSAMEVMAQIVLAPHLAGRFDDPDHIR------- 552

Human   764 QC--LLHRDMQALGVLLAEMVFATRVRTLQPDAPLWVRFQAVRGLCTRHPKEVPVSLQPVLDTLL 826
            :|  |....:.|....|.:.:|.|....  ||...:..|.:||       ..:|..:        
 Worm   553 RCIQLYSYRIPANYRRLFDFLFNTEQDF--PDCDEFSFFVSVR-------LNIPTKI-------- 600

Human   827 QMSGPEVPMGAERGKLDQLFEYRPVSQGLPPPCPSQLLSPFSSVVPFPPYFPALHRFILLYQAR- 890
                  :....|.||...|...|.:          .::.|||.          ..:.|:|.:.. 
 Worm   601 ------LNFSEEFGKCVSLHILRKL----------DVIPPFSK----------RSQLIILKEVES 639

Human   891 -----RVEDEAQGRELVFALWQQLGAVLKDITPEGLEILLPFVLSLMSEEHTAVYTAWYLFEPVA 950
                 |:.|..:  :.|.|.:||                      |:.:|...:.:...|...:.
 Worm   640 LKKSIRLCDHME--QCVVAAFQQ----------------------LLEDEEACIQSVHRLMPVIT 680

Human   951 KALGPKNANKYLLKPLIGAYESPCQ-----LHGRFYLYTD-CFVAQLMVRLGLQAFLTHLLPHVL 1009
            ::|. ::|.:.|:.|:|...:  |:     |..||.::.. |:        |...||...||.::
 Worm   681 RSLS-QSALEDLINPMIELIQ--CETSVKLLDRRFLMHVSICY--------GTHTFLDLFLPPIV 734

Human  1010 QVLAGAEASQEESKDLAGAAEEEESGLPGAGPGSCAFGEEIPMDGEPPASSGLGLPDYTSGVSFH 1074
            :..|..                           :|                              
 Worm   735 EACASM---------------------------NC------------------------------ 742

Human  1075 DQADLPETEDFQAGLYVTESPQPQEAEAVSLGRLSDKSSTSETSLGEERAPDEGGAPVDKSSLRS 1139
                                                                             
 Worm   743 ----------------------------------------------------------------- 742

Human  1140 GDSSQDLKQSEGSEEEEEEEDSCVVLEEEEGEQEEVTGASELTLSDTVLSMETVVAGGSGGDGEE 1204
                                |..||.:|.                                    
 Worm   743 --------------------DRSVVAKES------------------------------------ 751

Human  1205 EEEALPEQSEGKEQKILLDTACKMVRWLSAKLGPTVASRHVARNLLRLLTSCYVGPTRQQFTVSS 1269
                                    :.||:.:.||.:.::.::.|:||::.|||     :.|.:..
 Worm   752 ------------------------IMWLAKRYGPVICAKFISSNVLRIMASCY-----EAFEMVG 787

Human  1270 GESPPLSAGNIYQKRPVLGDIVSGPVLSCLLHIARLYGEPVLTYQYLPYISYLVAPGSASGPSRL 1334
            .|..|.:..|:.    :.||.....:.|.|..|...|....:|.|:||:...|:    .....|.
 Worm   788 LEQQPKAVFNVV----LQGDETCSRIESLLSEIVLTYSVTFITVQFLPFCVDLI----EQFHKRS 844

Human  1335 NSRKEAGLLAAVTLTQKIIVYLSDTTLMDILPR-ISHEVLLPVLSFLTSLVTGFPSGAQARTILC 1398
            :.:.|.||::...:.:..|..:||..||:.|.. |..:|:..||:.|......| |..:.|.|:.
 Worm   845 SVQLEPGLVSVFRIVELSIRSMSDHQLMNYLEEFIIQKVIYRVLTILLDASFQF-SSMRVRIIII 908

Human  1399 VKTISLIALICLRIGQEMVQQHLSEPVATFFQVFSQLHELRQQ---DLKLDPAGRGEGQLPQVVF 1460
            .|...|:..|..:||.|..:.:.::|....|..||:::|..::   :|:..|:.....::|..:.
 Worm   909 CKVCQLLHSITQKIGTENTRIYANQPFKLMFSTFSEIYETDEELRINLRKRPSENTLFEVPLWMV 973

Human  1461 SDGQQRPVDPALLDELQKVFTLEMAYTIYVPFSCLLGDIIRKIIPNHELVGELAALYLESISPSS 1525
            .|         ::|:..|.:.        |||.....|....:||           ::.:.|.||
 Worm   974 ED---------VVDKFAKEWG--------VPFLSSFCDDPAFLIP-----------FVSNSSSSS 1010

Human  1526 RNPASVEPTMPGTGPEWDPHGGGCPQDDGHSGTFGSVLVGNRIQIPNDSRPENPGPLGPISGVGG 1590
            ..|||:..:.|.....:               :.|.:..|||:...:.|.|.|     .::.:||
 Worm  1011 SPPASIAHSPPSAFTAY---------------SLGGMSSGNRLFSLSASSPVN-----SVNSLGG 1055

Human  1591 -GGLGSGSDDNALKQELPRSVHGLSGNWLAYWQYEIGVSQQDAHFHFHQIRLQSFPGHSGAVKCV 1654
             ....|||               ||..|.|  :....|...| ::.|..:.|.::.||...::.:
 Worm  1056 LSFCDSGS---------------LSAVWCA--RVSAAVCGVD-NYRFDHLSLCNYTGHQEKIRKL 1102

Human  1655 APLSSEDFFLSGSKDRTVRLWPLYNYGDGTSETAPRLVYTQHRKSVFFVGQLEAPQHVVSCDGAV 1719
            |.:|:|:.|:|.|.|:||:||.:....|   |...:..|.:|.:.|..:..| |...:.|.||.:
 Worm  1103 AAISNENSFVSASSDKTVKLWSIKPELD---EIGCQWTYQKHTRPVHDITIL-ADNSIASTDGVL 1163

Human  1720 HVWDPF---------------TGKTLRTVEPLDSRVPLTAVAVMPAPHTSITMASSDSTLRFVDC 1769
            ||||||               :|..:..||.:|..: |:|:            .|..||::..|.
 Worm  1164 HVWDPFRTTLLAQMEWDSKEGSGGNIMRVENVDRHI-LSAI------------CSLHSTVKLFDS 1215

Human  1770 RKPGLQHEFRLGGGLNPGLVRALAISPSGRSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQI 1834
            |..|...|.::..|  |||.||:.:...|..:....|:|.:.:||.|.|.:              
 Worm  1216 RVGGWTCELKVSPG--PGLTRAITVRDKGNKMAVALSNGTLAILDARNGKI-------------- 1264

Human  1835 KAVEGSVLVSSSSDHSLTV-WKE---------------LEQKP-THHYKSASDPIHTFDLYGSEV 1882
                 :.|..::|.|:::| |..               ||..| .|..:...||:....|..:.:
 Worm  1265 -----NALAQTNSTHTVSVNWLSDTRLLVCDADECGIFLETNPRAHIVRKLQDPVSAACLTDNSL 1324

Human  1883 VT---GTV------SNKIGVCSLLEPPSQATTKLSSENFRGTLTSLALLPTKRHLLLGSDNGVIR 1938
            ||   ||:      |.::          |..||:..:...||.|::..||.....|:||.:|.||
 Worm  1325 VTLQNGTILRVYRNSGEL----------QIETKIRPDELPGTPTAVLPLPLNCSYLIGSSHGAIR 1379

Human  1939 LL 1940
            |:
 Worm  1380 LM 1381

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WDR81NP_001157281.1 Necessary and sufficient for the interaction with SQSTM1. /evidence=ECO:0000269|PubMed:28404643 1..650 153/521 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27
Beach 351..591 CDD:100117 113/240 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 618..637 0/18 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 694..718 5/23 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1022..1074 1/51 (2%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1097..1217 4/119 (3%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1523..1556 6/32 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1569..1602 8/33 (24%)
WD 1 1639..1677 14/37 (38%)
WD40 <1640..1939 CDD:441893 86/339 (25%)
WD40 repeat 1652..1695 CDD:293791 14/42 (33%)
WD 2 1686..1724 12/37 (32%)
WD40 repeat 1700..1734 CDD:293791 13/48 (27%)
WD 3 1729..1769 8/39 (21%)
WD40 repeat 1743..1779 CDD:293791 8/35 (23%)
WD 4 1777..1815 11/37 (30%)
WD40 repeat 1789..1822 CDD:293791 9/32 (28%)
WD 5 1819..1856 5/37 (14%)
WD40 repeat 1831..1864 CDD:293791 8/49 (16%)
WD 6 1860..1896 10/45 (22%)
WD40 repeat 1871..1893 CDD:293791 7/30 (23%)
WD 7 1902..1941 15/39 (38%)
sorf-2NP_001367877.1 Beach 236..463 CDD:214982 113/242 (47%)
WD40 1062..1292 CDD:475233 70/285 (25%)
WD40 repeat 1099..1139 CDD:293791 13/42 (31%)
WD40 repeat 1163..1226 CDD:293791 19/75 (25%)
WD40 repeat 1233..1269 CDD:293791 10/54 (19%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.