DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment WDR81 and Wdr81

DIOPT Version :10

Sequence 1:NP_001157281.1 Gene:WDR81 / 124997 HGNCID:26600 Length:1941 Species:Homo sapiens
Sequence 2:NP_609535.1 Gene:Wdr81 / 34616 FlyBaseID:FBgn0032395 Length:1953 Species:Drosophila melanogaster


Alignment Length:2151 Identity:658/2151 - (30%)
Similarity:968/2151 - (45%) Gaps:455/2151 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    37 DLSIDPRQLAPAPGGTHVVALVPARWLASL-RDRRL---PLGPCPRAEGLGEAEVRTLLQR---S 94
            ::.:||:.:..|.|......:....||.|| |:|||   |..|              ||.|   .
  Fly    10 EIGVDPQHVCEAGGDGRFQVICDKAWLQSLERNRRLTHFPSWP--------------LLDRRSYP 60

Human    95 VQRLPAGWTRVEVHGLRKRRLS--YPL---GGGLPFEDGSCGPETLTRFMQEVAAQNYRNLWRHA 154
            :.:|...|||:.|...||:..|  |||   .|..|   .|..|.:.::.:..||..|::.||..|
  Fly    61 IGQLEHPWTRILVQTYRKQPQSRVYPLPRISGDAP---SSELPLSYSQAVSFVAHSNFKQLWEEA 122

Human   155 YHTYGQPY-----SHSPAPSAVPALDS---------VRQALQRVYGCSFLPVGETTQCPSYAREG 205
            |..|...:     |...|||..|....         :::.:||||.|..|      .| ...|:|
  Fly   123 YRKYNGAHVRMCRSTPSAPSTKPPSGQGQLQPHDVVLKELIQRVYRCPVL------HC-QLDRDG 180

Human   206 PCPPRGSPAC----------PSLLRAEALLESPEMLYVVHPYVQFSLHDVVTFSPAKLTNSQAKV 260
            ......:.:|          |:|:..|.........|  .|.::.||:|.:|||||.|..:..|.
  Fly   181 VSDSSNATSCSAGSCHANVLPALVAIETSTHISVFFY--PPALECSLYDCITFSPALLGKNYNKT 243

Human   261 LFILFRVLRAMDACHRQGLACGALSLYHIAVDEKL----CSELRLDLSAYERPEEDENEEAPVAR 321
            ||:::::|:.......|||..|.|.|..|.:.|.|    ...|:.:|...:...||.:...|:..
  Fly   244 LFVIYQILQLAKHLQGQGLFLGDLRLQDIVLRENLWLQVLPRLQCNLLDDDPAGEDMSPLTPLVS 308

Human   322 DEAGIVSQEEQGGQPGQPT----------GQEELRSLVLDWVHGRISNFHYLMQLNRLAGRRQGD 376
            ::.| .::|.|...|...|          ....||.....|.:|::|||.||..||...||...:
  Fly   309 EDLG-EAREAQQALPSSSTMFDLRFAYDPAHFNLREYTEMWCNGQLSNFDYLTILNNACGRSLTN 372

Human   377 PNYHPVLPWVVDFT-TPHGRFRDLRKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGGGEPPHVPHH 440
            ..||.::|||.||: ...|.:|||.|||:||||||..||..|....|...|.|:........|||
  Fly   373 AAYHHIMPWVTDFSGRGGGAWRDLTKSKYRLNKGDVHLDLMYAHASQHGSADGSYQAIGDQAPHH 437

Human   441 ISDVLSDITYYVYKARRTPRSVLCGHVRAQWEPHEYPASMERMQNWTPDECIPEFYTDPSIFRSI 505
            :||.||:|||:||.|||||:|:||.|||..|.|.|||.|::|:|.|||||||||||:||.||:||
  Fly   438 VSDFLSEITYFVYMARRTPQSILCAHVRPIWVPAEYPVSIQRLQEWTPDECIPEFYSDPMIFKSI 502

Human   506 HPDMPDLDVPAWCSSSQEFVAAHRALLESREVSRDLHHWIDLTFGYKLQGKEAVKEKNVCLHLVD 570
            |.|:|||::|||.:..::|:..||..|||:.||..|||||||.|||||.||.|||.|||||.|||
  Fly   503 HEDLPDLELPAWATCPEDFICKHREALESQYVSERLHHWIDLNFGYKLSGKAAVKSKNVCLTLVD 567

Human   571 AHTHLASYGVVQLFDQPHPQRLAGAPALAPEPPLIPKLLVQTIQETTGREDFTENPGQLPNGVGR 635
            .|.:|:..|:||||...||.|....|..:...|.:.:|.                          
  Fly   568 QHRNLSQRGIVQLFASAHPPRRYATPWFSRTAPRLSQLY-------------------------- 606

Human   636 PVLEATPCEASWTRDRPVAGEDDLEQATEALDSISLAGKAGDQLGSSSQASPGLLSFSVASASRP 700
                |:|.:.             |.::||.|.:.|..|.:...|......|.|.:..|.||||  
  Fly   607 ----ASPAKR-------------LAKSTENLQAESATGSSHLSLRLGDDGSSGSVHSSSASAS-- 652

Human   701 GRRNKAAGADPGEGEEGRILLPEGFNPMQALEELEKTGNFLAKGL---------------GGLL- 749
                    |.........|.|||.:||...|..||....|.|:..               ..|: 
  Fly   653 --------ASNFYAITNFIELPENYNPALLLHNLETLEAFYARTFPQQRASANPEEKMISSDLMF 709

Human   750 ------------------EVPEQPRVQPAVPLQCLLH-------RDMQALGVLLAEMVFATRVRT 789
                              |:|.:.:........||.|       ||:..||.|:.|:....|:|.
  Fly   710 EQNSAEHSFTNQLFASGDELPPKSKNLLREKRNCLQHLLNVRKERDLHVLGCLIIELFAMQRLRP 774

Human   790 LQPDAPLWV----RFQAVRGLCTRHPKEVPVSLQPVLDTLLQMSGPEVPMGAERGKLDQLFEYRP 850
            |.....|..    |..|.|.:...|.:|:|..::.|:..|||:..|    |.|            
  Fly   775 LLMGNGLTATFDSRLSACRTVAQLHRQELPKPVRRVVRLLLQLEQP----GEE------------ 823

Human   851 VSQGLP-PPCPSQLLSPFSS--VVPFPPYFPALH---RFILLYQARRVEDEAQ-------GREL- 901
             .|||| ||.|:|||.|..|  ::|||.::.|::   |.:..::|..|..|.|       |||. 
  Fly   824 -DQGLPQPPNPAQLLEPMFSNLLLPFPSHYMAVYALVRSLHAFEANAVLLELQTHFSCKGGRECE 887

Human   902 ---------------------------VFALWQQLGAVLKDITPEGLEILLPFVLSLMSEEHTAV 939
                                       |..|.:.:....:..||  :|:|||.::.|:.:|.|::
  Fly   888 RYTEMDRQRVLFERKIAECKVMSCCAHVKRLLEPMSFAYEQFTP--VELLLPHIIDLLRDERTSI 950

Human   940 YTAWYLFEPVAKALGPKNANKYLLKPLIGAYE-----SP----------CQLHGRF--------- 980
            .|||.||:|:|:|||.....::||:||:..|:     ||          ...|.||         
  Fly   951 LTAWNLFDPIAQALGVSQTQQHLLQPLLKLYDVESVSSPDDGGSNGSTNSGGHLRFSASSSFKSR 1015

Human   981 ---YLYTDCFVAQLMVRLGLQAFLTHLLPHVLQVLAG-------------AEASQEESKDLAGAA 1029
               .||...|:.:|:||.||:.||.|.:..:::.:.|             :..|:..||:|..|:
  Fly  1016 KSVKLYHHSFLLRLIVRFGLRCFLHHFIAPLIEAVGGYKEPEQGNGYHYHSGGSRRTSKNLNFAS 1080

Human  1030 EEEESGLPGAGPGSCAFGEEIPMDGEPPASSGLGLPDYTSGVSFHDQADLPETEDFQAGLYVTES 1094
            |.|            ....|:..:.:         ||.....:|.|..|...|:|.::.......
  Fly  1081 ENE------------VHQTEVAPEMK---------PDIEELFTFEDDHDRASTQDSKSIDSFDMR 1124

Human  1095 PQPQEAEA-----------------------VSLGRLSDKSS----------------TSETSLG 1120
            |....|.|                       :|..:||.|.|                |.|..:|
  Fly  1125 PSTSAASAEEARESDGSPDKLVINELIYGARISPDKLSLKESQTPPALVPPPIGPRSPTIEIPMG 1189

Human  1121 EERAPDEGG---------APVDKSSLRSGDS----SQDLKQSEGSEEEEEEEDSCVVLEEEEGEQ 1172
                |..||         ...|..|.:|.||    ||.::|.....||.|.|             
  Fly  1190 ----PTAGGIRRSFQLSAIDCDIGSRKSVDSFDLISQAVEQLPPPAEESEAE------------- 1237

Human  1173 EEVTGASELTLSDTVLSMETVVAGGSGGDGEEEEEALPEQSEGK--EQKILLDTACKMVRWLSAK 1235
                 ||: :|..:|:|                     ..||.|  :...:.:.:.:.:.|||.:
  Fly  1238 -----ASD-SLQASVIS---------------------RLSEAKAVQNNRISEMSAESLVWLSHR 1275

Human  1236 LGPTVASRHVARNLLRLLTSCYVGPTRQQFTVSSG-----ESPPLSAGNIYQ--KRPVLGDIVSG 1293
            |||.:.||.:.||||:||:.||||.......|..|     .||..:..|.:.  ...|:||..:.
  Fly  1276 LGPVLTSRFITRNLLKLLSLCYVGQENLLPEVDDGGSSFNSSPDAANLNYFSIANARVVGDRSAA 1340

Human  1294 PVLSCLLHIARLYGEPVLTYQYLPYISYLVAPGSASGPSRLNSRKEAGLLAAVTLTQKIIVYLSD 1358
            .||.||:.||.||||..|..||.|:||.|::..|    .|:....|..:::::.|.:.::..|:|
  Fly  1341 RVLECLMSIAALYGENFLLLQYFPHISELISLCS----KRITGSLEGAIISSLQLLKYMVPCLTD 1401

Human  1359 TTLMDILPRISHE-VLLPVLSFLTSLVTGFPSGAQARTILCVKTISLIALICLRIGQEMVQQHLS 1422
            .::|:.|..|..: :|||:|..|:|.....|||...|::|..|.:..|..:.:|:|.:|.::||.
  Fly  1402 ASIMEHLQHIMLDAILLPILRLLSSTNLVMPSGYLGRSLLARKFLDAIYALSVRLGSDMTREHLC 1466

Human  1423 EPVAT-FFQVFSQLHELRQQDLKLDPAGRGEGQLPQVVFSDGQQRPVDPALLDELQKVFTLEMAY 1486
            :|:.. ||.:|::...| ..|...|        |..:....|..:|  ...|:||:.||..|:|:
  Fly  1467 QPLLNPFFLIFNKAFGL-PNDFACD--------LANLSLVGGASQP--ERALEELRDVFGPELAH 1520

Human  1487 TIYVPFSCLLGDI-IRKIIPNHELVGELAALYLESISPSSRNPASVEPTMPGTGPEWDPHGGGCP 1550
            |.|:.|...||:. :::.:.|.:.|   ..|..|...|:.::...: .|...:|.:.|.....| 
  Fly  1521 TAYLTFLRFLGEANMKRTLSNLDFV---LTLCHEHEQPNGQSKIQL-ATNVSSGQDVDSVDASC- 1580

Human  1551 QDDGHSGTFGSVLVGNRIQIPNDSRPENPGPLGPISGVGGGGLGSGSDDNALK-QELPRSVHGLS 1614
              :..:.:||:.:||||:|:..::          :..:         |..|.| .::|::.| |.
  Fly  1581 --ELAANSFGTQIVGNRLQVARNN----------VELI---------DMVAYKLDQMPKTRH-LK 1623

Human  1615 GNWLAYWQYEIGVSQQDAH-FHFHQIRLQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLY 1678
            |||||||:.|...:::|.. .:..|||||||.||:.:|:.:..|.:|:.|:|.|||:||:||.|.
  Fly  1624 GNWLAYWRNETTRNEKDTQTLNLKQIRLQSFVGHTNSVRAIYALDNENSFISASKDKTVKLWSLR 1688

Human  1679 NYGDGTSETAPRLVYTQHRKSVFFVGQLEAPQHVVSCDGAVHVWDPFTGKTLRTVE-PLDSRVPL 1742
            :.|||...:|.:..||.|:||:..:|.||:.::|||||..:|:||||.|:.|..:: |..|.|  
  Fly  1689 SEGDGRKTSACQFTYTAHKKSINSLGFLESLRYVVSCDSGIHLWDPFIGRPLSVLDAPRHSAV-- 1751

Human  1743 TAVAVMPAPHTSITMASSDSTLRFVDCRKPGLQHEFRL-GGGLNPGLVRALAISPSGRSVVAGFS 1806
            |.|..:|:....:...:::||::.||.|.....:|:|: ...|....||.||::|||..:.||.|
  Fly  1752 TVVKCLPSHSPLVIAGTAESTVKMVDARSCEYVNEWRVCNASLPNATVRCLAVAPSGNWLAAGLS 1816

Human  1807 SGFMVLLDTRTGLVLRGWPAHEGDILQIKAVEGSVLVSSSSDHSLTVWKELEQKPTHHYKSASDP 1871
            ||.:|.||||||:|:..|...|.|:||:.|.....||||:.||||.||..|:....:..|...:|
  Fly  1817 SGCIVQLDTRTGMVINSWRPMECDLLQLAAPSDQFLVSSALDHSLAVWHALDGIMHYQLKPPPEP 1881

Human  1872 IHTFDLYGSEVVTGTVSNKIGV-CSLLEPPSQAT-TKLSSENFRGTLTSLALLPTKRHLLLGSDN 1934
            .|.....|..:|..|..|::|| ..:....:.:| |||.||.|||.|||||:||..|..|.|:::
  Fly  1882 AHFLQSVGPSLVYATTGNRVGVYADVAHSHAFSTITKLRSETFRGVLTSLAVLPLNRAFLAGNES 1946

Human  1935 GVIRLL 1940
            |.|.||
  Fly  1947 GNIALL 1952

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WDR81NP_001157281.1 Necessary and sufficient for the interaction with SQSTM1. /evidence=ECO:0000269|PubMed:28404643 1..650 235/663 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27
Beach 351..591 CDD:100117 135/240 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 618..637 0/18 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 694..718 5/23 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1022..1074 9/51 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1097..1217 33/173 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1523..1556 5/32 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1569..1602 2/32 (6%)
WD 1 1639..1677 20/37 (54%)
WD40 <1640..1939 CDD:441893 125/302 (41%)
WD40 repeat 1652..1695 CDD:293791 17/42 (40%)
WD 2 1686..1724 16/37 (43%)
WD40 repeat 1700..1734 CDD:293791 15/33 (45%)
WD 3 1729..1769 10/40 (25%)
WD40 repeat 1743..1779 CDD:293791 9/35 (26%)
WD 4 1777..1815 17/38 (45%)
WD40 repeat 1789..1822 CDD:293791 20/32 (63%)
WD 5 1819..1856 17/36 (47%)
WD40 repeat 1831..1864 CDD:293791 14/32 (44%)
WD 6 1860..1896 9/36 (25%)
WD40 repeat 1871..1893 CDD:293791 6/21 (29%)
WD 7 1902..1941 23/40 (58%)
Wdr81NP_609535.1 Beach 345..588 CDD:100117 135/242 (56%)
WD40 1651..1876 CDD:475233 94/226 (42%)
WD40 repeat 1662..1705 CDD:293791 17/42 (40%)
WD40 repeat 1710..1744 CDD:293791 15/33 (45%)
WD40 repeat 1752..1788 CDD:293791 9/35 (26%)
WD40 repeat 1799..1836 CDD:293791 21/36 (58%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.