Protein Alignment WDR81 and Wdr81

DIOPT Version :10

• Sequence 1: NP_001157281.1
• Gene: WDR81 / 124997
• HGNCID: 26600
• Length: 1941
• Species: Homo sapiens
• Sequence 2: XP_038941944.1
• Gene: Wdr81 / 303312
• RGDID: 1311334
• Length: 1944
• Species: Rattus norvegicus
• Alignment Length: 1954
• Identity: 1687/1954 - (86%)
• Similarity: 1781/1954 - (91%)
• Gaps: 23/1954 - (1%)

Human     1 MAQGSGGREGALRTPAGGWHSPPSPDMQELLRSVERDLSIDPRQLAPAPGGTHVVALVPARWLAS 65
            |||||..|:..|...|.|..|...|||:||||..||||:||.||||.|||||||||||..|||||
  Rat     1 MAQGSRRRKVVLTAGAEGCSSSSGPDMEELLRCAERDLNIDARQLALAPGGTHVVALVSTRWLAS 65

Human    66 LRDRRLPLGPCPRAEGLGEAEVRTLLQRSVQRLPAGWTRVEVHGLRKRRLSYPLGGGLPFEDGSC 130
            ||:||  |||||||||||||||||||||||||||.|||||||||||||||||||...||||:|||
  Rat    66 LRERR--LGPCPRAEGLGEAEVRTLLQRSVQRLPQGWTRVEVHGLRKRRLSYPLSRVLPFEEGSC 128

Human   131 GPETLTRFMQEVAAQNYRNLWRHAYHTYGQPYSHSPAPSAVPALDSVRQALQRVYGCSFLPVGET 195
            .||||||||||||||||||||||||||||||||||.||||:|||||:||||||||||:||||||:
  Rat   129 SPETLTRFMQEVAAQNYRNLWRHAYHTYGQPYSHSTAPSAIPALDSIRQALQRVYGCTFLPVGES 193

Human   196 TQCPSYAREGPCPPRGSPACPSLLRAEALLESPEMLYVVHPYVQFSLHDVVTFSPAKLTNSQAKV 260
            .||.|..|:|  |.|||.|||||||||||||||||||||||||||||||||||||||||||||||
  Rat   194 MQCLSNVRDG--PSRGSSACPSLLRAEALLESPEMLYVVHPYVQFSLHDVVTFSPAKLTNSQAKV 256

Human   261 LFILFRVLRAMDACHRQGLACGALSLYHIAVDEKLCSELRLDLSAYERPEEDENEEAPVARDEAG 325
            ||||||||||||||||||||||||||:||||||||||||||||||||.|.||||:|....:|..|
  Rat   257 LFILFRVLRAMDACHRQGLACGALSLHHIAVDEKLCSELRLDLSAYEMPSEDENQEVSEEKDRTG 321

Human   326 IVSQEEQGGQPGQPTGQEELRSLVLDWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVVDFT 390
            :.|:::..|:||.||.|:|||.|||||||||:|||:|||||||||||||||||||||||||||||
  Rat   322 VKSEKDGEGRPGCPTCQKELRGLVLDWVHGRVSNFYYLMQLNRLAGRRQGDPNYHPVLPWVVDFT 386

Human   391 TPHGRFRDLRKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGGGEPPHVPHHISDVLSDITYYVYKA 455
            ||:|||||||||||||||||||||||||||||||||||||.|||.||||||||||||||||||||
  Rat   387 TPYGRFRDLRKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGSGEPLHVPHHISDVLSDITYYVYKA 451

Human   456 RRTPRSVLCGHVRAQWEPHEYPASMERMQNWTPDECIPEFYTDPSIFRSIHPDMPDLDVPAWCSS 520
            |||||||||||||||||||||||:|||||.|||||||||||||||||.|||||||||||||||||
  Rat   452 RRTPRSVLCGHVRAQWEPHEYPATMERMQTWTPDECIPEFYTDPSIFCSIHPDMPDLDVPAWCSS 516

Human   521 SQEFVAAHRALLESREVSRDLHHWIDLTFGYKLQGKEAVKEKNVCLHLVDAHTHLASYGVVQLFD 585
            :||||.||||||||.|||:||||||||||||||||||||||||||||||||||||.|||||||||
  Rat   517 NQEFVTAHRALLESWEVSQDLHHWIDLTFGYKLQGKEAVKEKNVCLHLVDAHTHLTSYGVVQLFD 581

Human   586 QPHPQRLAGAPALAPEPPLIPKLLVQTIQETTGREDFTENPGQLPNGVGRPVLEATPCEASWTRD 650
            |||||||||||||||||||||:||||.|||.||:||.:   |||.||.||.|:|.||||:.|||:
  Rat   582 QPHPQRLAGAPALAPEPPLIPRLLVQPIQEATGQEDIS---GQLINGAGRHVVEVTPCESGWTRE 643

Human   651 RPVAGEDDLEQATEALDSISLAGKAGDQLG-SSSQASPGLLSFSVASASRPGRRNKAAGADPGEG 714
            ||.|||||||||||||||||:.||||||.| ||||||||||.||..|.||||||:||.|.|.|||
  Rat   644 RPTAGEDDLEQATEALDSISIPGKAGDQPGSSSSQASPGLLPFSAPSGSRPGRRSKATGLDSGEG 708

Human   715 EEGRILLPEGFNPMQALEELEKTGNFLAKGLGGLLEVPEQPRVQPAVPLQCLLHRDMQALGVLLA 779
            :||:|:|||||:|:||||||||.|||||:|||..||.||:|:.||.|.||.|.|||||.||||||
  Rat   709 DEGKIVLPEGFSPIQALEELEKVGNFLARGLGSQLEEPEKPQAQPPVYLQSLFHRDMQVLGVLLA 773

Human   780 EMVFATRVRTLQPDAPLWVRFQAVRGLCTRHPKEVPVSLQPVLDTLLQMSGPEVPMGAERGKLDQ 844
            |||||||||.|||||||||||:|||||||||.|::|||||||||||||:|||:.|:..::||||.
  Rat   774 EMVFATRVRILQPDAPLWVRFEAVRGLCTRHSKDIPVSLQPVLDTLLQLSGPKSPLVVKKGKLDP 838

Human   845 LFEYRPVSQGLPPPCPSQLLSPFSSVVPFPPYFPALHRFILLYQARRVEDEAQGRELVFALWQQL 909
            ||||||||||||||.|:|||||||||||||.||||||:|||||||||||||.|||||||||||||
  Rat   839 LFEYRPVSQGLPPPSPAQLLSPFSSVVPFPTYFPALHKFILLYQARRVEDEVQGRELVFALWQQL 903

Human   910 GAVLKDITPEGLEILLPFVLSLMSEEHTAVYTAWYLFEPVAKALGPKNANKYLLKPLIGAYESPC 974
            ||||.:||||||||||||||||||||||||||||||||||||||||||..||||||||||||:||
  Rat   904 GAVLNEITPEGLEILLPFVLSLMSEEHTAVYTAWYLFEPVAKALGPKNTIKYLLKPLIGAYENPC 968

Human   975 QLHGRFYLYTDCFVAQLMVRLGLQAFLTHLLPHVLQVLAGAEASQEESKDLAGAAEEEESGLPGA 1039
            :||||||||||||||||:|||||||||.||||||||||||.||||||.|.|.|..|:||:.||..
  Rat   969 RLHGRFYLYTDCFVAQLVVRLGLQAFLIHLLPHVLQVLAGVEASQEEGKGLVGTTEDEENELPVP 1033

Human  1040 GPGSCAFGEEIPMDGEPPASSGLGLPDYTSGVSFHDQADLPETEDFQAGLYVTESPQPQEAEAVS 1104
            |||||||||||.|.|:|.||||||||||.||||||||||||:||||||||||.||||||||||||
  Rat  1034 GPGSCAFGEEIQMGGQPAASSGLGLPDYRSGVSFHDQADLPDTEDFQAGLYVAESPQPQEAEAVS 1098

Human  1105 LGRLSDKSSTSETSLGEERAPDEGGAPVDKSSLRSGDSSQDLKQSEGSEEEEEEEDSCVVLEEEE 1169
            ||:|||||||||.|.||||..|:|||||||:|::|||||||||||||||||||||:.|||||||
  Rat  1099 LGQLSDKSSTSEASQGEERGGDDGGAPVDKNSVKSGDSSQDLKQSEGSEEEEEEEEGCVVLEEE- 1162

Human  1170 GEQEEVTGASELTLSDTVLSMETVVAGGSGGDGEEEEEALPEQSEGKEQKILLDTACKMVRWLSA 1234
             ||:||||.||||||||:||||||||.|.|.|.|||||.||||:|||||||||||||||||||||
  Rat  1163 -EQDEVTGTSELTLSDTILSMETVVAPGDGRDREEEEEPLPEQTEGKEQKILLDTACKMVRWLSA 1226

Human  1235 KLGPTVASRHVARNLLRLLTSCYVGPTRQQFTVSSGESPPLSAGNIYQKRPVLGDIVSGPVLSCL 1299
            ||||||||||||||||||||||||||||||||||..:||||:|||||||||||||||||||||||
  Rat  1227 KLGPTVASRHVARNLLRLLTSCYVGPTRQQFTVSCDDSPPLNAGNIYQKRPVLGDIVSGPVLSCL 1291

Human  1300 LHIARLYGEPVLTYQYLPYISYLVAPGSASGPSRLNSRKEAGLLAAVTLTQKIIVYLSDTTLMDI 1364
            ||||.|||||||||||||||||||||||.|.||||||||||||||||||||||||||||||||||
  Rat  1292 LHIAHLYGEPVLTYQYLPYISYLVAPGSNSSPSRLNSRKEAGLLAAVTLTQKIIVYLSDTTLMDI 1356

Human  1365 LPRISHEVLLPVLSFLTSLVTGFPSGAQARTILCVKTISLIALICLRIGQEMVQQHLSEPVATFF 1429
            ||||||||||||||||||.||||||||||||:|||||||||||||||||||||||||||||||||
  Rat  1357 LPRISHEVLLPVLSFLTSFVTGFPSGAQARTVLCVKTISLIALICLRIGQEMVQQHLSEPVATFF 1421

Human  1430 QVFSQLHELRQQDLKLDPAGRGEGQLPQVVFSDGQQRPVDPALLDELQKVFTLEMAYTIYVPFSC 1494
            ||||.|||||||||:||..|..|||||:..|||||:|||||.||:||||||||||||||||||||
  Rat  1422 QVFSHLHELRQQDLQLDLKGCTEGQLPEATFSDGQRRPVDPTLLEELQKVFTLEMAYTIYVPFSC 1486

Human  1495 LL-----------GDIIRKIIPNHELVGELAALYLESISPSS-RNPASVEPTMPGTGPEWDPHGG 1547
            ||           ||||||||||||||||||.|||||:|||| |||||:||..|..||||:|..|
  Rat  1487 LLGIAHHVPLHRVGDIIRKIIPNHELVGELAGLYLESMSPSSLRNPASMEPVTPSAGPEWNPQSG 1551

Human  1548 GCPQDDGHSGTFGSVLVGNRIQIPNDSRPENPGPLGPISGVGGGGLGSGSDDNALKQELPRSVHG 1612
            .|.||||||||||||||||||||| ||:|::.||||.|||||.|||.|.::|||||:|||||.||
  Rat  1552 SCLQDDGHSGTFGSVLVGNRIQIP-DSQPQSSGPLGSISGVGSGGLSSRNEDNALKRELPRSAHG 1615

Human  1613 LSGNWLAYWQYEIGVSQQDAHFHFHQIRLQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPL 1677
            |||||||||||||||||||||||||||||||||||:|||||||.|||||||||||||||||||||
  Rat  1616 LSGNWLAYWQYEIGVSQQDAHFHFHQIRLQSFPGHTGAVKCVAALSSEDFFLSGSKDRTVRLWPL 1680

Human  1678 YNYGDGTSETAPRLVYTQHRKSVFFVGQLEAPQHVVSCDGAVHVWDPFTGKTLRTVEPLDSRVPL 1742
            ||||||||||||||:|.|||||||:||||||||:||||||||||||||||||||||:|.||||||
  Rat  1681 YNYGDGTSETAPRLIYAQHRKSVFYVGQLEAPQYVVSCDGAVHVWDPFTGKTLRTVDPSDSRVPL 1745

Human  1743 TAVAVMPAPHTSITMASSDSTLRFVDCRKPGLQHEFRLGGGLNPGLVRALAISPSGRSVVAGFSS 1807
            ||||||||||||||||||||||||||||||||||||||||||||||||:||:|||||||||||||
  Rat  1746 TAVAVMPAPHTSITMASSDSTLRFVDCRKPGLQHEFRLGGGLNPGLVRSLAVSPSGRSVVAGFSS 1810

Human  1808 GFMVLLDTRTGLVLRGWPAHEGDILQIKAVEGSVLVSSSSDHSLTVWKELEQKPTHHYKSASDPI 1872
            ||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||
  Rat  1811 GFMVLLDTRTGLVLRGWPAHEGDILQIKAVEGSVIVSSSSDHSLTVWKELEQKPTHHYKSASDPI 1875

Human  1873 HTFDLYGSEVVTGTVSNKIGVCSLLEPPSQATTKLSSENFRGTLTSLALLPTKRHLLLGSDNGVI 1937
            |||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||:|
  Rat  1876 HTFDLYGSEVVTGTVANKIGVCSLLEPPSQATTKLSSENFRGTLTSLALLPTKRHLLLGSDNGII 1940

Human  1938 RLLA 1941
            ||||
  Rat  1941 RLLA 1944

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WDR81	NP_001157281.1	Necessary and sufficient for the interaction with SQSTM1. /evidence=ECO:0000269|PubMed:28404643	1..650		551/648 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		11/25 (44%)
		Beach	351..591	CDD:100117	226/239 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	618..637		10/18 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	694..718		15/23 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1022..1074		36/51 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1097..1217		97/119 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1523..1556		22/33 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1569..1602		21/32 (66%)
		WD 1	1639..1677		35/37 (95%)
		WD40	<1640..1939	CDD:441893	285/298 (96%)
		WD40 repeat	1652..1695	CDD:293791	40/42 (95%)
		WD 2	1686..1724		33/37 (89%)
		WD40 repeat	1700..1734	CDD:293791	31/33 (94%)
		WD 3	1729..1769		37/39 (95%)
		WD40 repeat	1743..1779	CDD:293791	35/35 (100%)
		WD 4	1777..1815		35/37 (95%)
		WD40 repeat	1789..1822	CDD:293791	30/32 (94%)
		WD 5	1819..1856		35/36 (97%)
		WD40 repeat	1831..1864	CDD:293791	31/32 (97%)
		WD 6	1860..1896		34/35 (97%)
		WD40 repeat	1871..1893	CDD:293791	20/21 (95%)
		WD 7	1902..1941		37/38 (97%)
Wdr81	XP_038941944.1	Beach	347..587	CDD:100117	226/239 (95%)
		WD40	<1643..1942	CDD:441893	285/298 (96%)
		WD40 repeat	1655..1698	CDD:293791	40/42 (95%)
		WD40 repeat	1703..1737	CDD:293791	31/33 (94%)
		WD40 repeat	1746..1782	CDD:293791	35/35 (100%)
		WD40 repeat	1792..1825	CDD:293791	30/32 (94%)
		WD40 repeat	1834..1867	CDD:293791	31/32 (97%)
		WD40 repeat	1874..1896	CDD:293791	20/21 (95%)