Protein Alignment WDR81 and Wdr81

DIOPT Version :10

• Sequence 1: NP_001157281.1
• Gene: WDR81 / 124997
• HGNCID: 26600
• Length: 1941
• Species: Homo sapiens
• Sequence 2: XP_006532609.1
• Gene: Wdr81 / 192652
• MGIID: 2681828
• Length: 1945
• Species: Mus musculus
• Alignment Length: 1954
• Identity: 1700/1954 - (87%)
• Similarity: 1792/1954 - (91%)
• Gaps: 22/1954 - (1%)

Human     1 MAQGSGGREGALRTPAGGWHSPPSPDMQELLRSVERDLSIDPRQLAPAPGGTHVVALVPARWLAS 65
            |||||..|:..|...:.||.....|||:||||||||||:||.||||.|||||||||||..|||||
Mouse     1 MAQGSRRRKVVLTAGSEGWSPSSGPDMEELLRSVERDLNIDARQLALAPGGTHVVALVSTRWLAS 65

Human    66 LRDRRLPLGPCPRAEGLGEAEVRTLLQRSVQRLPAGWTRVEVHGLRKRRLSYPLGGGLPFEDGSC 130
            ||:||  |||||||||||||||||||||||||||.||||||||||||||||||||||:|||:|||
Mouse    66 LRERR--LGPCPRAEGLGEAEVRTLLQRSVQRLPPGWTRVEVHGLRKRRLSYPLGGGVPFEEGSC 128

Human   131 GPETLTRFMQEVAAQNYRNLWRHAYHTYGQPYSHSPAPSAVPALDSVRQALQRVYGCSFLPVGET 195
            .||||||||||||||||||||||||||||||||||.||||:|||||:||||||||||:||||||:
Mouse   129 SPETLTRFMQEVAAQNYRNLWRHAYHTYGQPYSHSTAPSALPALDSIRQALQRVYGCTFLPVGES 193

Human   196 TQCPSYAREGPCPPRGSPACPSLLRAEALLESPEMLYVVHPYVQFSLHDVVTFSPAKLTNSQAKV 260
            ..|.|..|:||||.|||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   194 IPCLSNVRDGPCPSRGSPACPSLLRAEALLESPEMLYVVHPYVQFSLHDVVTFSPAKLTNSQAKV 258

Human   261 LFILFRVLRAMDACHRQGLACGALSLYHIAVDEKLCSELRLDLSAYERPEEDENEEAPVARDEAG 325
            ||:|||||||||||||||||||||||:||||||||||||||||||||.|.||||:|....::..|
Mouse   259 LFLLFRVLRAMDACHRQGLACGALSLHHIAVDEKLCSELRLDLSAYEMPSEDENQEGSEEKNGTG 323

Human   326 IVSQEEQGGQPGQPTGQEELRSLVLDWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVVDFT 390
            |.|::|..|:...||.|:|||.|||||||||||||||||||||||||||||||||||||||||||
Mouse   324 IKSEKEGEGRTECPTCQKELRGLVLDWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVVDFT 388

Human   391 TPHGRFRDLRKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGGGEPPHVPHHISDVLSDITYYVYKA 455
            ||:|||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||
Mouse   389 TPYGRFRDLRKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGSGEPPHVPHHISDVLSDITYYVYKA 453

Human   456 RRTPRSVLCGHVRAQWEPHEYPASMERMQNWTPDECIPEFYTDPSIFRSIHPDMPDLDVPAWCSS 520
            |||||||||||||||||||||||:|||||.|||||||||||||||||.|||||||||||||||||
Mouse   454 RRTPRSVLCGHVRAQWEPHEYPATMERMQTWTPDECIPEFYTDPSIFCSIHPDMPDLDVPAWCSS 518

Human   521 SQEFVAAHRALLESREVSRDLHHWIDLTFGYKLQGKEAVKEKNVCLHLVDAHTHLASYGVVQLFD 585
            :|||||||||||||.|||:||||||||||||||||||||||||||||||||||||.|||||||||
Mouse   519 NQEFVAAHRALLESWEVSQDLHHWIDLTFGYKLQGKEAVKEKNVCLHLVDAHTHLTSYGVVQLFD 583

Human   586 QPHPQRLAGAPALAPEPPLIPKLLVQTIQETTGREDFTENPGQLPNGVGRPVLEATPCEASWTRD 650
            |||||||||:|||||||||||:||||.|:|.||:||.:   |||.||.||.|:||||||..||||
Mouse   584 QPHPQRLAGSPALAPEPPLIPRLLVQPIREATGQEDIS---GQLINGAGRLVVEATPCETGWTRD 645

Human   651 RPVAGEDDLEQATEALDSISLAGKAGDQLG-SSSQASPGLLSFSVASASRPGRRNKAAGADPGEG 714
            ||..|||||||||||||||||.||||||.| |||||||||||||..|.||||||:||||.|||||
Mouse   646 RPGTGEDDLEQATEALDSISLPGKAGDQPGSSSSQASPGLLSFSAPSGSRPGRRSKAAGLDPGEG 710

Human   715 EEGRILLPEGFNPMQALEELEKTGNFLAKGLGGLLEVPEQPRVQPAVPLQCLLHRDMQALGVLLA 779
            |||:|:|||||:|:||||||||.|||||||||..||.||:|..||.|.||.|.|||||.||||||
Mouse   711 EEGKIVLPEGFSPIQALEELEKVGNFLAKGLGSQLEEPEKPHAQPPVHLQSLFHRDMQVLGVLLA 775

Human   780 EMVFATRVRTLQPDAPLWVRFQAVRGLCTRHPKEVPVSLQPVLDTLLQMSGPEVPMGAERGKLDQ 844
            |||||||||.|||||||||||:||||||.||.|::|||||||||||||:|||:.||.:::||||.
Mouse   776 EMVFATRVRILQPDAPLWVRFEAVRGLCIRHSKDIPVSLQPVLDTLLQLSGPKSPMVSKKGKLDP 840

Human   845 LFEYRPVSQGLPPPCPSQLLSPFSSVVPFPPYFPALHRFILLYQARRVEDEAQGRELVFALWQQL 909
            ||||||||||||||.|:||||||||||||||||||||:|||||||||||||.|||||.|||||||
Mouse   841 LFEYRPVSQGLPPPSPAQLLSPFSSVVPFPPYFPALHKFILLYQARRVEDEVQGRELAFALWQQL 905

Human   910 GAVLKDITPEGLEILLPFVLSLMSEEHTAVYTAWYLFEPVAKALGPKNANKYLLKPLIGAYESPC 974
            ||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   906 GAVLNDITPEGLEILLPFVLSLMSEEHTAVYTAWYLFEPVAKALGPKNANKYLLKPLIGAYESPC 970

Human   975 QLHGRFYLYTDCFVAQLMVRLGLQAFLTHLLPHVLQVLAGAEASQEESKDLAGAAEEEESGLPGA 1039
            :||||||||||||||||:||||||||||||||||||||||.||||||.|.|.|..|:|||.||.:
Mouse   971 RLHGRFYLYTDCFVAQLVVRLGLQAFLTHLLPHVLQVLAGVEASQEEGKGLVGTTEDEESELPVS 1035

Human  1040 GPGSCAFGEEIPMDGEPPASSGLGLPDYTSGVSFHDQADLPETEDFQAGLYVTESPQPQEAEAVS 1104
            |||||||||||.|||:|.||||||||||.||||||||||||:||||||||||.||||||||||||
Mouse  1036 GPGSCAFGEEIQMDGQPAASSGLGLPDYRSGVSFHDQADLPDTEDFQAGLYVAESPQPQEAEAVS 1100

Human  1105 LGRLSDKSSTSETSLGEERAPDEGGAPVDKSSLRSGDSSQDLKQSEGSEEEEEEEDSCVVLEEEE 1169
            ||:|||||||||.|.||||..|:||||.||:|::||||||||||||||||||||| .||||||:
Mouse  1101 LGQLSDKSSTSEASQGEERGGDDGGAPADKNSVKSGDSSQDLKQSEGSEEEEEEE-GCVVLEED- 1163

Human  1170 GEQEEVTGASELTLSDTVLSMETVVAGGSGGDGEEEEEALPEQSEGKEQKILLDTACKMVRWLSA 1234
             :::||||.||||||||:||||||||.|.|.|.|||||.|.||:|||||||||||||||||||||
Mouse  1164 -QEDEVTGTSELTLSDTMLSMETVVAPGDGRDREEEEEPLTEQTEGKEQKILLDTACKMVRWLSA 1227

Human  1235 KLGPTVASRHVARNLLRLLTSCYVGPTRQQFTVSSGESPPLSAGNIYQKRPVLGDIVSGPVLSCL 1299
            |||||||||||||||||||||||||||||||||||.::|||:|||||||||||||||||||||||
Mouse  1228 KLGPTVASRHVARNLLRLLTSCYVGPTRQQFTVSSDDTPPLNAGNIYQKRPVLGDIVSGPVLSCL 1292

Human  1300 LHIARLYGEPVLTYQYLPYISYLVAPGSASGPSRLNSRKEAGLLAAVTLTQKIIVYLSDTTLMDI 1364
            ||||.|||||||||||||||||||||||.|.||||||||||||||||||||||||||||||||||
Mouse  1293 LHIAYLYGEPVLTYQYLPYISYLVAPGSNSNPSRLNSRKEAGLLAAVTLTQKIIVYLSDTTLMDI 1357

Human  1365 LPRISHEVLLPVLSFLTSLVTGFPSGAQARTILCVKTISLIALICLRIGQEMVQQHLSEPVATFF 1429
            |||||||||||||.||||.||||||||||||:|||||||||||||||||||||||||||||||||
Mouse  1358 LPRISHEVLLPVLGFLTSFVTGFPSGAQARTVLCVKTISLIALICLRIGQEMVQQHLSEPVATFF 1422

Human  1430 QVFSQLHELRQQDLKLDPAGRGEGQLPQVVFSDGQQRPVDPALLDELQKVFTLEMAYTIYVPFSC 1494
            ||||.|||||||||.|||.|..|||||:..|||||:|||||.||:||||||||||||||||||||
Mouse  1423 QVFSHLHELRQQDLPLDPKGCTEGQLPEATFSDGQRRPVDPTLLEELQKVFTLEMAYTIYVPFSC 1487

Human  1495 LL-----------GDIIRKIIPNHELVGELAALYLESISPSSRNPASVEPTMPGTGPEWDPHGGG 1548
            ||           ||||||||||||||||||.|||||:|||||||||:||||...||||||..|.
Mouse  1488 LLGIAHHVPLHRVGDIIRKIIPNHELVGELAGLYLESMSPSSRNPASMEPTMASAGPEWDPQSGS 1552

Human  1549 CPQDDGHSGTFGSVLVGNRIQIPNDSRPENPGPLGPISGVG-GGGLGSGSDDNALKQELPRSVHG 1612
            |.||||||||||||||||||||| ||:|::|||||.:|||| .|||.:.::|||||:|||||.||
Mouse  1553 CLQDDGHSGTFGSVLVGNRIQIP-DSQPQSPGPLGSLSGVGSSGGLSNRNEDNALKRELPRSAHG 1616

Human  1613 LSGNWLAYWQYEIGVSQQDAHFHFHQIRLQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPL 1677
            |||||||||||||||||||||||||||||||||||:|||||||.|||||||||||||||||||||
Mouse  1617 LSGNWLAYWQYEIGVSQQDAHFHFHQIRLQSFPGHTGAVKCVAALSSEDFFLSGSKDRTVRLWPL 1681

Human  1678 YNYGDGTSETAPRLVYTQHRKSVFFVGQLEAPQHVVSCDGAVHVWDPFTGKTLRTVEPLDSRVPL 1742
            |||||||:|||.||:|.|||||||:||||||||:||||||||||||||||||||||:|.||||||
Mouse  1682 YNYGDGTNETASRLIYAQHRKSVFYVGQLEAPQYVVSCDGAVHVWDPFTGKTLRTVDPSDSRVPL 1746

Human  1743 TAVAVMPAPHTSITMASSDSTLRFVDCRKPGLQHEFRLGGGLNPGLVRALAISPSGRSVVAGFSS 1807
            ||||||||||||||||||||||||||||||||||||||||||||||||:||:|||||||||||||
Mouse  1747 TAVAVMPAPHTSITMASSDSTLRFVDCRKPGLQHEFRLGGGLNPGLVRSLAVSPSGRSVVAGFSS 1811

Human  1808 GFMVLLDTRTGLVLRGWPAHEGDILQIKAVEGSVLVSSSSDHSLTVWKELEQKPTHHYKSASDPI 1872
            |||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||
Mouse  1812 GFMVLLDTRTGLVLRGWPAHEGDILQIKAVEGSVLISSSSDHSLTVWKELEQKPTHHYKSASDPI 1876

Human  1873 HTFDLYGSEVVTGTVSNKIGVCSLLEPPSQATTKLSSENFRGTLTSLALLPTKRHLLLGSDNGVI 1937
            |||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||:|
Mouse  1877 HTFDLYGSEVVTGTVANKIGVCSLLEPPSQATTKLSSENFRGTLTSLALLPTKRHLLLGSDNGII 1941

Human  1938 RLLA 1941
            ||||
Mouse  1942 RLLA 1945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WDR81	NP_001157281.1	Necessary and sufficient for the interaction with SQSTM1. /evidence=ECO:0000269|PubMed:28404643	1..650		557/648 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		10/25 (40%)
		Beach	351..591	CDD:100117	230/239 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	618..637		10/18 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	694..718		18/23 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1022..1074		38/51 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1097..1217		92/119 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1523..1556		24/32 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1569..1602		20/33 (61%)
		WD 1	1639..1677		35/37 (95%)
		WD40	<1640..1939	CDD:441893	283/298 (95%)
		WD40 repeat	1652..1695	CDD:293791	38/42 (90%)
		WD 2	1686..1724		32/37 (86%)
		WD40 repeat	1700..1734	CDD:293791	31/33 (94%)
		WD 3	1729..1769		37/39 (95%)
		WD40 repeat	1743..1779	CDD:293791	35/35 (100%)
		WD 4	1777..1815		35/37 (95%)
		WD40 repeat	1789..1822	CDD:293791	30/32 (94%)
		WD 5	1819..1856		35/36 (97%)
		WD40 repeat	1831..1864	CDD:293791	31/32 (97%)
		WD 6	1860..1896		34/35 (97%)
		WD40 repeat	1871..1893	CDD:293791	20/21 (95%)
		WD 7	1902..1941		37/38 (97%)
Wdr81	XP_006532609.1	Beach	349..589	CDD:100117	230/239 (96%)
		WD40	<1644..1943	CDD:441893	283/298 (95%)
		WD40 repeat	1656..1699	CDD:293791	38/42 (90%)
		WD40 repeat	1704..1738	CDD:293791	31/33 (94%)
		WD40 repeat	1747..1783	CDD:293791	35/35 (100%)
		WD40 repeat	1793..1826	CDD:293791	30/32 (94%)
		WD40 repeat	1835..1868	CDD:293791	31/32 (97%)
		WD40 repeat	1875..1897	CDD:293791	20/21 (95%)