Protein Alignment WDR81 and wdr81

DIOPT Version :10

• Sequence 1: NP_001157281.1
• Gene: WDR81 / 124997
• HGNCID: 26600
• Length: 1941
• Species: Homo sapiens
• Sequence 2: XP_002937192.2
• Gene: wdr81 / 100485582
• XenbaseID: XB-GENE-6258221
• Length: 1871
• Species: Xenopus tropicalis
• Alignment Length: 1942
• Identity: 1162/1942 - (59%)
• Similarity: 1429/1942 - (73%)
• Gaps: 98/1942 - (5%)

Human    27 MQELLRSVERDLSIDPRQLAPAPGGTHVVALVPARWLASLRDRRLPLGPCPRAEGLGEAEVRTLL 91
            |:.||.:|:::|:||.|||..|..||||:|||..:||||:::||.....||:.||....|::|.|
 Frog     1 MEWLLEAVKKELNIDSRQLIMAEEGTHVIALVSQKWLASIKERRTVSSQCPKPEGFSSVEIQTFL 65

Human    92 QRSVQRLPAGWTRVEVHGLRKRRLSYPLGGGLPFEDG-SCGPETLTRFMQEVAAQNYRNLWRHAY 155
            ||||.:|||||||:|:||:||.||:||:.....|.:| :...|:|.||||.:|.|||.|:|..|.
 Frog    66 QRSVHKLPAGWTRIEIHGVRKERLAYPVALNDGFLEGKNIDSESLIRFMQCIAVQNYNNMWNAAR 130

Human   156 HTYGQPYSHSPAPSAVPALDSVRQALQRVYGCSFLPVGETTQCPSYAREGPCPPRGSPACPSLLR 220
            .||.|||.......::.|||:::.:|||||||.|:.:.:.....|.:::......|:.:..::::
 Frog   131 RTYVQPYESVHKVPSIQALDALKLSLQRVYGCPFVFINKAVPSLSPSKDSSSFVLGASSSSNIVQ 195

Human   221 AEALLESPEMLYVVHPYVQFSLHDVVTFSPAKLTNSQAKVLFILFRVLRAMDACHRQGLACGALS 285
            |||||||..:||::.||:|:||:||||||||||.||.|||||||:.||:|:.|||:.||:.|||:
 Frog   196 AEALLESVSILYIILPYIQYSLYDVVTFSPAKLANSHAKVLFILYNVLQALKACHQGGLSSGALT 260

Human   286 LYHIAVDEKLCSELRLDLSAYERPEEDENEEAPVARDEAGIVSQEEQGGQPGQPTG-QEELRSLV 349
            |..:.|||||||:||.:...|||       |....:.:..|  ..||....|..|. ..||:.::
 Frog   261 LRSVLVDEKLCSQLRPNFIDYER-------ECKSTKVKENI--NTEQLRTVGLCTSCNNELKQIL 316

Human   350 LDWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVVDFTTPHGRFRDLRKSKFRLNKGDKQLD 414
            :||:||||||:.|||.||:|||||:|||||||||||||||||.:|:|||||||||||||||||||
 Frog   317 IDWIHGRISNYDYLMYLNKLAGRREGDPNYHPVLPWVVDFTTKNGKFRDLRKSKFRLNKGDKQLD 381

Human   415 FTYEMTRQAFVAGGAGGGEPPHVPHHISDVLSDITYYVYKARRTPRSVLCGHVRAQWEPHEYPAS 479
            ||||||:|||||||: ..:..||||||||||||||||||||||||:.|||.|||:||||:|||||
 Frog   382 FTYEMTKQAFVAGGS-SSDHLHVPHHISDVLSDITYYVYKARRTPKIVLCNHVRSQWEPNEYPAS 445

Human   480 MERMQNWTPDECIPEFYTDPSIFRSIHPDMPDLDVPAWCSSSQEFVAAHRALLESREVSRDLHHW 544
            |||||.||||||||||||||:||:|||.|||||::|:||||.::|:..||||||||:||:|||||
 Frog   446 MERMQGWTPDECIPEFYTDPTIFKSIHTDMPDLEIPSWCSSYEDFIHVHRALLESRDVSQDLHHW 510

Human   545 IDLTFGYKLQGKEAVKEKNVCLHLVDAHTHLASYGVVQLFDQPHPQRLAGAPALAPEPPLIPKLL 609
            |||||||||.||.|:.||||||||||.||:|..:|||||||||||:||.|....:.|||.|  |.
 Frog   511 IDLTFGYKLTGKNALMEKNVCLHLVDNHTNLTCFGVVQLFDQPHPKRLLGPSCSSFEPPAI--LS 573

Human   610 VQTIQETTGREDFTENPGQLPNGVGRPVLEATPCEASWTRDRPVAGEDDLEQATEALDSISLAGK 674
            .|.|.:.:..:|  |:.|   |||..||:|||.|||.|..|:..||:::|||.||||||:|:.||
 Frog   574 TQNISQMSAWKD--EHTG---NGVNGPVVEATVCEAVWNTDKVCAGDEELEQGTEALDSLSIVGK 633

Human   675 AGDQLGSSSQASPGLLSFSVASASRPGRRNKAAGADP---------GEGEEGRILLPEGFNPMQA 730
            ..||:        .:.|..|.||:.....|:..|:.|         .|..:.::|||:.|||:||
 Frog   634 GNDQV--------CIPSVQVTSANIFQGENRPPGSKPNRISRATTNAEESQRKLLLPDSFNPVQA 690

Human   731 LEELEKTGNFLAKGL-GGLLEVPEQPRVQPAVPLQCLLHRDMQALGVLLAEMVFATRVRTLQPDA 794
            ||||||..|||.:|| ..||.|.:..::.| :.|..|..||||||||::||:|||.::.|..|..
 Frog   691 LEELEKLDNFLLRGLHSTLLPVEKSSKIFP-LSLLGLFQRDMQALGVMIAEIVFAGKIHTTPPKT 754

Human   795 PLWVRFQAVRGLCTRHPKEVPVSLQPVLDTLLQMSGPEVPM----GAERGKLDQLFEYRPVSQGL 855
            .|..|:..||.|...||||:|:.|..:|::|||:..||..:    |.:.|.|  |||:..:|:||
 Frog   755 SLLERYILVRNLSRHHPKEIPLPLLQMLESLLQLHTPEEELLKDGGEDTGAL--LFEFPHISKGL 817

Human   856 PPPCPSQLLSPFSSVVPFPPYFPALHRFILLYQARRVEDEAQGRELVFALWQQLGAVLKDITPEG 920
            ||||||.||||..|::|||.|||.||:|||.||:||.|||:|||||||.||||:..:|.:|.|||
 Frog   818 PPPCPSLLLSPLCSIIPFPAYFPNLHKFILTYQSRRTEDESQGRELVFQLWQQIDGILCEINPEG 882

Human   921 LEILLPFVLSLMSEEHTAVYTAWYLFEPVAKALGPKNANKYLLKPLIGAYESPCQLHGRFYLYTD 985
            ||||||||||||:||.||||.||||||||||||||||:|||||||||||||||..|:||||||||
 Frog   883 LEILLPFVLSLMTEESTAVYAAWYLFEPVAKALGPKNSNKYLLKPLIGAYESPSHLNGRFYLYTD 947

Human   986 CFVAQLMVRLGLQAFLTHLLPHVLQVLAGAEASQEESKDLAGAAEEEESGLPGAGPGSCAFGEEI 1050
            ||||||:|||||||||::||.||||:|.|.|.|.||.|.|:|.||:||||  |..|.||.|||..
 Frog   948 CFVAQLIVRLGLQAFLSNLLNHVLQILIGLETSGEERKLLSGGAEDEESG--GDSPVSCNFGEAR 1010

Human  1051 PMDGEPPASSGLGLPDYTSGVSFHDQADLPETEDFQAGLYVTESPQPQEAEAVSLGRLSDKSSTS 1115
            ....:..|||. .|.||||||:||||..|.|.||||..|||::..||||.|::||||||||||.|
 Frog  1011 QTSIDQSASSH-ELLDYTSGVTFHDQGYLAENEDFQGTLYVSDPLQPQEPESLSLGRLSDKSSAS 1074

Human  1116 ETSLGEERAPDEGGAPVDKSSLRSGDSSQDLKQSEGSEEEEEEEDSCVVLEEEEGEQEEVTGASE 1180
            |.|||:|:..|..... :|.||:||||||||||||.|||||:.|.|              .|.||
 Frog  1075 EVSLGDEKVTDSDSLK-EKGSLKSGDSSQDLKQSEESEEEEDREPS--------------PGLSE 1124

Human  1181 LTLS-DTVLSMETVVAGGSGGDGEEEEEALPEQSEGKEQKILLDTACKMVRWLSAKLGPTVASRH 1244
            |||| :|.:|::||:|..|..| ||||:.|..|:|.||||||:||.|||||||||||||||.||:
 Frog  1125 LTLSVNTDVSVDTVLASESRED-EEEEQDLNNQTEEKEQKILIDTTCKMVRWLSAKLGPTVTSRY 1188

Human  1245 VARNLLRLLTSCYVGPTRQQFTVSSGESPPLSAGNIYQKRPVLGDIVSGPVLSCLLHIARLYGEP 1309
            :|||||||||||||||.||||..:..|:.|||.     |:||.||.||.|||.||:::|.|||||
 Frog  1189 IARNLLRLLTSCYVGPQRQQFVANMEENSPLSV-----KKPVCGDQVSKPVLDCLMYLAHLYGEP 1248

Human  1310 VLTYQYLPYISYLVAPGSASGPSRLNSRKEAGLLAAVTLTQKIIVYLSDTTLMDILPRISHEVLL 1374
            .|||||||||:|||||.|.   .||||||||.|||||||||||||||||||||||||:|:.:|||
 Frog  1249 FLTYQYLPYINYLVAPTSG---CRLNSRKEASLLAAVTLTQKIIVYLSDTTLMDILPKINQDVLL 1310

Human  1375 PVLSFLTSLVTGFPSGAQARTILCVKTISLIALICLRIGQEMVQQHLSEPVATFFQVFSQLHELR 1439
            ||||.|||...|||||||||..||||..||::|||||||:|||||||.:.:..||..|:.:.||.
 Frog  1311 PVLSILTSATLGFPSGAQARIALCVKCSSLLSLICLRIGREMVQQHLGDTLRIFFSNFTLMQELH 1375

Human  1440 QQDLKLDPAGRGEGQLPQVVFSDGQQRPVDPALLDELQKVFTLEMAYTIYVPFSCLLGDIIRKII 1504
            :|.|.::.....|..:..|...||...|||.:|||||:||:..||||..|||||||:||.|..:|
 Frog  1376 EQGLVMENPDSLEPVVQHVQCKDGSTLPVDLSLLDELEKVYNAEMAYATYVPFSCLIGDGIGHVI 1440

Human  1505 PNHELVGELAALYLESISPSS-RNPASVEPTMPGT--GPEWDPHGGGCPQDDGHSGTFGSVLVGN 1566
            |||:|:.:|..:|.|.:.|.. .:||:  |...|:  |..:     ...:|||.|||||||:|||
 Frog  1441 PNHDLIWKLTMVYQEGVIPKDIESPAA--PLSSGSRIGSSF-----YIAEDDGQSGTFGSVMVGN 1498

Human  1567 RIQIPND-----SRPENPGPLGPISGVGGGGLGSGSDDNALKQELPRSVHGLSGNWLAYWQYEIG 1626
            |||:|.|     ||.....|:...         ..||:|:.||:|.::..||.||||||||||||
 Frog  1499 RIQVPKDIQYPMSRSTCCTPVMET---------FQSDENSFKQDLQKNAQGLCGNWLAYWQYEIG 1554

Human  1627 VSQQDAHFHFHQIRLQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLYNYGDGTSETAPRL 1691
            ||||:.||.||||:||||.|||||:|||.|||.||||:|||||:||||||||||||||.:...|.
 Frog  1555 VSQQEPHFCFHQIKLQSFVGHSGAIKCVKPLSGEDFFMSGSKDKTVRLWPLYNYGDGTRDIEARH 1619

Human  1692 VYTQHRKSVFFVGQLEAPQHVVSCDGAVHVWDPFTGKTLRTVEPLDSRVPLTAVAVMPAPHTSIT 1756
            :|.:|::|||:|||||:.|.:||||||||:||.:|||::||.|..||::|:||||.||.|:.|:|
 Frog  1620 IYAEHKRSVFYVGQLESVQQLVSCDGAVHIWDQYTGKSIRTYEAADSKLPITAVATMPPPYCSVT 1684

Human  1757 MASSDSTLRFVDCRKPGLQHEFRLGGGLNPGLVRALAISPSGRSVVAGFSSGFMVLLDTRTGLVL 1821
            :.|:||.|||:|.|||||||||:|...:|.||:|.||:||:|||||||:||||::||||||||||
 Frog  1685 VGSADSILRFIDLRKPGLQHEFKLASNVNAGLIRCLAVSPNGRSVVAGYSSGFIILLDTRTGLVL 1749

Human  1822 RGWPAHEGDILQIKAVEGSVLVSSSSDHSLTVWKELEQKPTHHYKSASDPIHTFDLYGSEVVTGT 1886
            ||||||||||||:||.:|:::||||:||||||||||||||.|.:||.|||||.|||||:|:||||
 Frog  1750 RGWPAHEGDILQMKAADGNIVVSSSTDHSLTVWKELEQKPLHQFKSNSDPIHVFDLYGNEIVTGT 1814

Human  1887 VSNKIGVCSLLEPPS--QATTKLSSENFRGTLTSLALLPTKRHLLLGSDNGVIRLLA 1941
            |:||||:.|:|:..:  .:||||||||||||||:||:|||||.|||||||||:||||
 Frog  1815 VANKIGIYSMLDSLALPNSTTKLSSENFRGTLTNLAVLPTKRLLLLGSDNGVVRLLA 1871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WDR81	NP_001157281.1	Necessary and sufficient for the interaction with SQSTM1. /evidence=ECO:0000269|PubMed:28404643	1..650		367/624 (59%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		1162/1942 (60%)
		Beach	351..591	CDD:100117	193/239 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	618..637		6/18 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	694..718		7/32 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1022..1074		26/51 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1097..1217		64/120 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1523..1556		9/35 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1569..1602		9/37 (24%)
		WD 1	1639..1677		30/37 (81%)
		WD40	<1640..1939	CDD:441893	212/300 (71%)
		WD40 repeat	1652..1695	CDD:293791	31/42 (74%)
		WD 2	1686..1724		21/37 (57%)
		WD40 repeat	1700..1734	CDD:293791	23/33 (70%)
		WD 3	1729..1769		21/39 (54%)
		WD40 repeat	1743..1779	CDD:293791	24/35 (69%)
		WD 4	1777..1815		24/37 (65%)
		WD40 repeat	1789..1822	CDD:293791	25/32 (78%)
		WD 5	1819..1856		29/36 (81%)
		WD40 repeat	1831..1864	CDD:293791	24/32 (75%)
		WD 6	1860..1896		25/35 (71%)
		WD40 repeat	1871..1893	CDD:293791	17/21 (81%)
		WD 7	1902..1941		32/38 (84%)
wdr81	XP_002937192.2	Protein Kinases, catalytic domain	188..>267	CDD:473864	45/78 (58%)
		Beach	318..557	CDD:100117	193/239 (81%)
		WD40	<1569..1869	CDD:441893	212/299 (71%)
		WD40 repeat	1580..1623	CDD:293791	31/42 (74%)
		WD40 repeat	1628..1662	CDD:293791	23/33 (70%)
		WD40 repeat	1671..1705	CDD:293791	22/33 (67%)
		WD40 repeat	1712..1753	CDD:293791	31/40 (78%)
		WD40 repeat	1761..1794	CDD:293791	23/32 (72%)
		WD40 repeat	1802..1822	CDD:293791	15/19 (79%)
		WD40 repeat	1846..1869	CDD:293791	18/22 (82%)