DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment WDR81 and wdr81

DIOPT Version :10

Sequence 1:NP_001157281.1 Gene:WDR81 / 124997 HGNCID:26600 Length:1941 Species:Homo sapiens
Sequence 2:NP_001411020.1 Gene:wdr81 / 100333062 ZFINID:ZDB-GENE-030131-3389 Length:2065 Species:Danio rerio


Alignment Length:2134 Identity:1132/2134 - (53%)
Similarity:1388/2134 - (65%) Gaps:288/2134 - (13%)


- Green bases have known domain annotations that are detailed below.


Human    27 MQELLRSVERDLSIDPRQLAPAPGGTHVVALVPARWLASLRDRRLPLGPCPRAEGLGEAEVRTLL 91
            |:.|..::||||.||.||.|.:.....:|.|||.||:.:||::|:.  .|.:.|...|.|:.|||
Zfish     1 MEWLAPALERDLGIDQRQTAHSQRPNELVVLVPTRWVMALRNKRVT--RCAKYESFSEGEICTLL 63

Human    92 QRSVQRLPAGWTRVEVHGLRKRRLSYPLGGGLPFEDGSCGPETLTR-----FMQEVAAQNYRNLW 151
            |||..:||:|||||.:.|||||:|.|...     .:..|..|.|::     .||.|:..|:||||
Zfish    64 QRSQMKLPSGWTRVCIQGLRKRKLGYRFA-----RETGCHGEGLSQDSFMTLMQGVSQSNFRNLW 123

Human   152 RHAYHTYGQPYSHSPAPSAVPALDSVRQALQRVYGCSFLPVGETTQ--CPSYAREGPCP------ 208
            ..||.|:.|||:.|...:.|.|||:||||||:::..:|:.....:.  .|:..:|..||      
Zfish   124 HEAYMTHVQPYADSVEQTPVLALDAVRQALQKLFCSNFISTDRVSPSLSPAKEKEKDCPFLSTCS 188

Human   209 -PRGS--PACPSLLRAEALLESPEMLYVVHPYVQFSLHDVVTFSPAKLTNSQAKVLFILFRVLRA 270
             |:.|  ..||::|.||.||||.|:||||.||.|:::||:||:|||||.||.||:||||:::|.|
Zfish   189 APKQSTESLCPNVLPAECLLESEEVLYVVFPYTQYTVHDIVTYSPAKLANSNAKILFILYQLLIA 253

Human   271 MDACHRQGLACGALSLYHIAVDEKLCSELRLDLSAYERPEEDENEEAPVARDEAGIVS----QEE 331
            |..||..||.||.|||..|||||:|||.|::.|:.||:.:| ..:..|.|......:|    ...
Zfish   254 MRECHASGLLCGELSLLDIAVDEQLCSRLKISLAHYEKFKE-YRDAVPYALQNKVPMSVSTKDNH 317

Human   332 QGGQPGQ--PTGQEELRSLVLDWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVVDFTTPHG 394
            ..|..||  ...|:||:|||||||:|::|||.|||:||||||||:||||||||||||||||.|:|
Zfish   318 NNGVSGQLCRNCQDELKSLVLDWVNGQVSNFQYLMELNRLAGRREGDPNYHPVLPWVVDFTVPYG 382

Human   395 RFRDLRKSKFRLNKGDKQLDFTYEMTRQAF--VAGGAGGGEPP-----------------HVPHH 440
            |||||:||||||||||||||||||||::|.  |:|..|...||                 |||||
Zfish   383 RFRDLKKSKFRLNKGDKQLDFTYEMTKEALAAVSGSGGSNYPPDLGGPVVPGGPGQSDHLHVPHH 447

Human   441 ISDVLSDITYYVYKARRTPRSVLCGHVRAQWEPHEYPASMERMQNWTPDECIPEFYTDPSIFRSI 505
            ||||||||||||||||:||:||||.|||:||||:||||||||:|:|||||||||||.||||||||
Zfish   448 ISDVLSDITYYVYKARQTPKSVLCSHVRSQWEPNEYPASMERIQSWTPDECIPEFYRDPSIFRSI 512

Human   506 HPDMPDLDVPAWCSSSQEFVAAHRALLESREVSRDLHHWIDLTFGYKLQGKEAVKEKNVCLHLVD 570
            ||||||||||.||:|.:||:|.||.||||||||:.|||||||||||||.||||:|.|||||||||
Zfish   513 HPDMPDLDVPPWCNSYEEFIAVHRQLLESREVSQQLHHWIDLTFGYKLSGKEAIKAKNVCLHLVD 577

Human   571 AHTHLASYGVVQLFDQPHPQRLAGAPALAPEPPLIPKLLVQTIQ----ETTGREDFTENPGQLPN 631
            .||||.|||||||||.|||.|||......||||...::.|.|.|    |||            .:
Zfish   578 NHTHLTSYGVVQLFDHPHPPRLALYQYAPPEPPHFGRVNVTTWQIPPLETT------------MD 630

Human   632 GVGRPVLEATPCEAS-WTRDRPVAGED-DLEQATEALD----------SISL------AGK-AGD 677
            ||...|.|||.||:| |:    |.|.| :||||.||||          |:|:      ||| :|:
Zfish   631 GVDGLVPEATGCESSGWS----VVGRDEELEQAIEALDLSGSSSSTSASVSIPVVGSAAGKTSGE 691

Human   678 QLG---SSSQAS-PGLLSFSVASASRPGRR----NKAAGA----DPGEGEEGRILLPEGFNPMQA 730
            .:|   |.|..| ||..:.:|.:....|.|    ::||..    :....|:.:|.||:||.|:|.
Zfish   692 TIGLVVSPSHGSFPGEATGNVTNTLGSGIRTAMLHRAASVSKKPEASNLEDFKISLPDGFKPLQP 756

Human   731 LEELEKTGNFLAKGLGGLLE-------VPEQPRVQPAVPLQC--LLHRDMQALGVLLAEMVFATR 786
            ||||||...||.|||...:|       ..:..|..|.|||..  |..|||||||||:||:.::::
Zfish   757 LEELEKLNTFLVKGLHSEIEHTMDLGINKKDLRSVPKVPLSFTDLFQRDMQALGVLIAEIFYSSK 821

Human   787 VRTLQPDAPLWVRFQAVRGLCTRHPKEVPVSLQPVLDTLLQMSGPEV--------PMGAERGKLD 843
            :|.|:|:..|..|||||..||:.:.::||:.|...||||||:....:        |.|     |.
Zfish   822 LRGLRPETHLRDRFQAVLKLCSTNLRDVPLPLHHALDTLLQVHKHCLKTETIIMHPQG-----LP 881

Human   844 QLFEYRPVSQGLPPPCPSQLLSPFSSVVPFPPYFPALHRFILLYQARRVE-DEAQGRELVFALWQ 907
            .||:|.|:.:|||||.|.|||||..|.:|||.|||.||:||..|.::... :..|||::||.|||
Zfish   882 FLFKYDPICEGLPPPNPWQLLSPIVSPLPFPEYFPTLHKFIFSYHSKMESINNIQGRDIVFNLWQ 946

Human   908 QLGAVLK-DITPEGLEILLPFVLSLMSEEHTAVYTAWYLFEPVAKALGPKNANKYLLKPLIGAYE 971
            ||..:|| |||.|||||||||||||||||.||||.||||||||::.|||:||:|||:|||:|.||
Zfish   947 QLETLLKGDITTEGLEILLPFVLSLMSEESTAVYAAWYLFEPVSRVLGPRNASKYLIKPLVGVYE 1011

Human   972 SPCQLHGRFYLYTDCFVAQLMVRLGLQAFLTHLLPHVLQVLAGAEASQ-------EESKDLAGAA 1029
            :|..|.|||||||||||.||:||||||.||:.||||||||:.|.|:..       |..|.|.|||
Zfish  1012 NPRCLRGRFYLYTDCFVLQLIVRLGLQVFLSSLLPHVLQVMTGFESCNTAAGTEWEGMKVLRGAA 1076

Human  1030 -----EEEE-------------SGLPGAGPGSCAFGEEIPMDGEPPASSGLGLPDYTSGVSFHDQ 1076
                 ||||             ||..|.|.|..:.|..:..|        .||.||:||:|.:||
Zfish  1077 GALDEEEEEYECDDRRSSNATSSGKVGGGSGGGSGGVGVVGD--------QGLVDYSSGISLNDQ 1133

Human  1077 ADLPETEDFQAGLYVTESP-----------------QPQEAEAVSLGRLSDKSSTSETSLGEERA 1124
            ..|.|.||||.|.||..|.                 :.|:.|::|:|:||||||.||.|:|    
Zfish  1134 VFLNEGEDFQNGFYVNNSASGATTVGTKQQNQSTANKDQDQESLSVGKLSDKSSASEVSIG---- 1194

Human  1125 PDEGGAPVDKSSLRSGDSSQDLKQSEGSEEEEEEEDSCVVLEEEEGEQEEVT----GASELTLSD 1185
                    |::||:|.||||||||:...|:..|.||     |||..|..|:|    .:.|:|||.
Zfish  1195 --------DRASLKSADSSQDLKQASDGEDGGELED-----EEETVEDREITVQRVPSLEMTLSV 1246

Human  1186 TVLSMETVVAGGSGG--------DG-----EEEEEALP-EQSEGKEQKILLDTACKMVRWLSAKL 1236
            .....|..||...|.        ||     |||.|..| |.||.||.||||||.||.||||||||
Zfish  1247 CTEESEATVATLEGDVMNGIVQEDGEKNMEEEETEHDPLEDSEEKEHKILLDTVCKTVRWLSAKL 1311

Human  1237 GPTVASRHVARNLLRLLTSCYVGPTRQQFTVSSGESPPLS-AGNIYQKRPVLGDIVSGPVLSCLL 1300
            |||:.||.:||||||||||||:|..:.||.:|..|...|. .|::|:|:||:||..:.|||.||:
Zfish  1312 GPTLTSRFIARNLLRLLTSCYIGLDKHQFMLSVNEENSLECVGSVYEKKPVVGDQTARPVLECLI 1376

Human  1301 HIARLYGEPVLTYQYLPYISYLVAPGSASGPSRLNSRKEAGLLAAVTLTQKIIVYLSDTTLMDIL 1365
            :||.|||||||||||||||.|||:|.|:   .|||:|||||||.||.|||||||:||||||||:|
Zfish  1377 YIAHLYGEPVLTYQYLPYIGYLVSPPSS---CRLNTRKEAGLLGAVVLTQKIIVFLSDTTLMDML 1438

Human  1366 PRISHEVLLPVLSFLTSLVTGFPSGAQARTILCVKTISLIALICLRIGQEMVQQHLSEPVATFFQ 1430
            .:|:.|||||:|..|||...|||||.|.|:.:|:||:||:||||||||:||||||::|.::.|||
Zfish  1439 MKINQEVLLPLLDLLTSTKMGFPSGVQTRSAVCLKTLSLMALICLRIGREMVQQHMAETLSRFFQ 1503

Human  1431 VFSQLHELRQQDLKLDPAGRGEG--------QLPQVVFSDGQQRPVDPALLDELQKVFTLEMAYT 1487
            |||.|..|:.|   :..|.|.|.        ::|     ||.:..::..:|:|||.||..||||.
Zfish  1504 VFSLLQFLQNQ---IGSAPRREVAECTYLDLRIP-----DGAELTIELGVLEELQAVFNPEMAYA 1560

Human  1488 IYVPFSCLLGDI-IRKIIPNHELVGELAALYLESISPSS--RNP--------ASVEPTM------ 1535
            .|:||.||:||. |||::.|||||..||..|.|..||.|  .||        ..:.|:|      
Zfish  1561 SYIPFYCLIGDSGIRKLVTNHELVWSLAQSYHERASPGSPESNPVGGQRASAVGLSPSMGRQMSR 1625

Human  1536 ---PGTGPEWDPHGGG-CPQDDGHSGTFGSVLVGNRIQIPNDS-----------------RP--E 1577
               |.......|.||. .|:    ||||||.|||||||:..|:                 ||  .
Zfish  1626 SPFPAPSSTSTPLGGDILPE----SGTFGSHLVGNRIQVTRDTEACGSPNLSSLETWTHGRPYGS 1686

Human  1578 NPGPLG----PISGVG--------GGGLGSGSDDNALKQELPRSVHGLSGNWLAYWQYEIGVSQQ 1630
            |..|:.    .:|..|        ...:|...:|:||||:||||...|.||||||||||||::||
Zfish  1687 NAPPMSLATTALSSAGPSFSHSSYSWVMGPTPEDSALKQDLPRSSRSLQGNWLAYWQYEIGLNQQ 1751

Human  1631 DAHFHFHQIRLQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLYNYGDGTSETAPRLVYTQ 1695
            |:||||||||||||.||||..||:|||:.||:|||||||:|||||||||:||||.|..|||.||:
Zfish  1752 DSHFHFHQIRLQSFIGHSGTAKCLAPLAGEDYFLSGSKDKTVRLWPLYNHGDGTREVEPRLTYTE 1816

Human  1696 HRKSVFFVGQLEAPQHVVSCDGAVHVWDPFTGKTLRTVEPLDSRVPLTAVAVMPAPHTSITMASS 1760
            ||||:|:||||||.|.||||||.||:||.||||.:|..||||.:.|:|||..|||||.|:..||:
Zfish  1817 HRKSIFYVGQLEALQEVVSCDGTVHLWDQFTGKNIRCNEPLDGKNPITAVTTMPAPHCSVVFASA 1881

Human  1761 DSTLRFVDCRKPGLQHEFRLG-GGLNPGLVRALAISPSGRSVVAGFSSGFMVLLDTRTGLVLRGW 1824
            ||.|||:|.|||||||||||. ..|:.||:|.||:||.||::.||||:||:||||.|||||||||
Zfish  1882 DSVLRFIDPRKPGLQHEFRLAYSNLSAGLIRCLAVSPGGRTIAAGFSTGFIVLLDARTGLVLRGW 1946

Human  1825 PAHEGDILQIKAVEGSVLVSSSSDHSLTVWKELEQKPTHHYKSASDPIHTFDLYGSEVVTGTVSN 1889
            |.|||||||:||.||::||||||||:|||||::|.||.|.|::.|||||.|||||:|:|.|||:|
Zfish  1947 PGHEGDILQMKAAEGNLLVSSSSDHTLTVWKDVEHKPLHQYRTPSDPIHAFDLYGAEIVAGTVAN 2011

Human  1890 KIGVCSLLEPPSQ--ATTKLSSENFRGTLTSLALLPTKRHLLLGSDNGVIRLLA 1941
            ||||.|:|:..:.  .:||||:||||||||||::|||||.||||||||.|||||
Zfish  2012 KIGVYSILDSTASLAGSTKLSTENFRGTLTSLSVLPTKRLLLLGSDNGAIRLLA 2065

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WDR81NP_001157281.1 Necessary and sufficient for the interaction with SQSTM1. /evidence=ECO:0000269|PubMed:28404643 1..650 372/668 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27 1132/2134 (53%)
Beach 351..591 CDD:100117 198/258 (77%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 618..637 2/18 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 694..718 6/31 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1022..1074 23/69 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1097..1217 54/137 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1523..1556 11/52 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1569..1602 10/63 (16%)
WD 1 1639..1677 29/37 (78%)
WD40 <1640..1939 CDD:441893 211/301 (70%)
WD40 repeat 1652..1695 CDD:293791 32/42 (76%)
WD 2 1686..1724 27/37 (73%)
WD40 repeat 1700..1734 CDD:293791 23/33 (70%)
WD 3 1729..1769 22/39 (56%)
WD40 repeat 1743..1779 CDD:293791 25/35 (71%)
WD 4 1777..1815 23/38 (61%)
WD40 repeat 1789..1822 CDD:293791 22/32 (69%)
WD 5 1819..1856 30/36 (83%)
WD40 repeat 1831..1864 CDD:293791 23/32 (72%)
WD 6 1860..1896 24/35 (69%)
WD40 repeat 1871..1893 CDD:293791 16/21 (76%)
WD 7 1902..1941 30/40 (75%)
wdr81NP_001411020.1 Beach 339..598 CDD:100117 198/258 (77%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1082..1111 9/28 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1156..1230 34/90 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1271..1290 8/18 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1595..1642 11/46 (24%)
WD40 <1761..2063 CDD:441893 211/301 (70%)
WD 1. /evidence=ECO:0000255 1767..1806 30/38 (79%)
WD 2. /evidence=ECO:0000255 1813..1853 28/39 (72%)
WD40 repeat 1822..1859 CDD:293791 26/36 (72%)
WD40 repeat 1863..1900 CDD:293791 25/36 (69%)
WD 3. /evidence=ECO:0000255 1906..1945 26/38 (68%)
WD40 repeat 1912..1947 CDD:293791 25/34 (74%)
WD 4. /evidence=ECO:0000255 1948..1986 27/37 (73%)
WD40 repeat 1953..1988 CDD:293791 24/34 (71%)
WD40 repeat 1996..2033 CDD:293791 20/36 (56%)
WD 5. /evidence=ECO:0000255 2035..2065 25/29 (86%)
WD40 repeat 2040..2063 CDD:293791 18/22 (82%)

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